Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide
Keywords: تولوباتید; PLGA; Chitosan; Tolbutamide; Diabetic; Hypoglycemic effect;
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Somatostatin promotes glucose generation of Ca2+oscillations in pancreatic islets both in the absence and presence of tolbutamide
Keywords: تولوباتید; Acetylcholine; Calcium oscillations; Cyclic AMP; Islet size; Somatostatin; Tolbutamide;
ATP-sensitive inwardly rectifying potassium channel modulators alter cardiac function in honey bees
Keywords: تولوباتید; Honey bee; Heart rate; Ion channels; KATP channels; Tolbutamide; Pinacidil;
The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats
Keywords: تولوباتید; diabetes-induced complications; interaction; pomegranate juice; tolbutamide;
In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats
Keywords: تولوباتید; Gymnema sylvestre; Diabetes; Triterpenoids; Steroids; Pharmacokinetic; CYP450-Herb drug interaction; CYP; CytochromeP450; PK; Pharmacokinetics; GS; Gymnema sylvestre; HDI; Herb drug interaction; EL; Ethanolic extract; GA; Gymnemic acid; HRLC-MS; High reso
The Effect of Genetic Polymorphism on the Inhibition of Azole Antifungal Agents Against CYP2C9-Mediated Metabolism
Keywords: تولوباتید; azole antifungal agents; fluconazole; voriconazole; CYP2C9 polymorphism; tolbutamide;
Role of cytochrome P450-mediated metabolism and identification of novel thiol-conjugated metabolites in mice with phenytoin-induced liver injury
Keywords: تولوباتید; ABT; 1-aminobenzotriazole; ALT; alanine aminotransferase; BSO; l-buthionine-(S,R)-sulfoximine; Cys; cysteine; DPH; phenytoin; γ-GCS; γ-glutamilcysteine synthetase; 4â²-HPPH; 5-(4â²-hydroxyphenyl)-5-phenylhydantoin; MDZ; midazolam; NAC; N-acetylcystein
Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?
Keywords: تولوباتید; NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; 2NF; 2-nitrofluorene; MTT test; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test; TPA; 12-O-tetradecanoylphorbol-13-acetate; AFB1; Aflatoxin B1; BaP; benzo(a)pyrene; CA; chromosome aber
Effect of tolbutamide, glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice
Keywords: تولوباتید; Kainic acid; Neuronal cell death; Sulfonylureas; Blood glucose; Tolbutamide; Glyburide; Glipizide
Research ReportGenetic and pharmacological manipulations that alter metabolism suppress seizure-like activity in Drosophila
Keywords: تولوباتید; SLA; Seizure-like activity; BS; Bang-sensitive; CS; Canton-S; EAS; Easily-shocked; BSS; Bang-senseless; TKO; Technical-knockout; Seizure; Epilepsy; Metabolism; Dystroglycan; Tolbutamide; Drosophila;
Microdose pharmacogenetic study of 14C-tolbutamide in healthy subjects with accelerator mass spectrometry to examine the effects of CYP2C9∗3 on its pharmacokinetics and metabolism
Keywords: تولوباتید; Microdose; Accelerator mass spectrometry (AMS); CYP2C9; Genetic polymorphism; Tolbutamide
Chronic dopamine depletion augments the functional expression of K-ATP channels in the rat subthalamic nucleus
Keywords: تولوباتید; STN; subthalamic nucleus; NMDA; N-methyl-d-aspartate; K-ATP; ATP-sensitive K+; 6-OHDA; 6-hydroxydopamine; ANOVA with RM; analysis of variance with repeated measures; ATP-sensitive K+ channel; Subthalamic nucleus; N-Methyl-d-aspartate; Sulfonylurea; Tolbut
Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats
Keywords: تولوباتید; BT; Bu-Zhong-Yi-Qi-Tang; CYP; Cytochrome P-450; DME; Drug-metabolizing enzymes; GSH; Reduced glutathione; GST; Glutathione S-transferase; GSSG; Oxidized glutathione; HPLC; High-performance liquid chromatography; MS; Mass spectrometry; NQO1; NADPH quinone
Coprecipitation on slurry to prepare drug–silica-polymer formulations by compressed antisolvent
Keywords: تولوباتید; Co-precipitation; Silica; Polymer; Supercritical; Antisolvent; Slurry; Tolbutamide
Binding of tolbutamide to glycated human serum albumin
Keywords: تولوباتید; Tolbutamide; Human serum albumin; Glycation; Drug-protein binding; High-performance affinity chromatography
A Study on Drug-Drug Interaction of Esomeprazole and Anti-Diabetic Drugs
Keywords: تولوباتید; Drug-drug interaction; esomeprazole; glibenclamide; tolbutamide;
Effects of some commonly used Saudi folk herbal medications on the metabolic activity of CYP2C9 in human liver microsomes
Keywords: تولوباتید; Herb; Interaction; CYP2C9; Tolbutamide; Metabolism; Human liver microsomes
Blockade of presynaptic K ATP channels reduces the zinc-mediated posttetanic depression at hippocampal mossy fiber synapses
Keywords: تولوباتید; Zinc; Tolbutamide; Presynaptic KATP channel; Voltage-dependent calcium channel (VDCC);
Gap junctions and memory: An investigation using a single trial discrimination avoidance task for the neonate chick
Keywords: تولوباتید; Gap junctions; Astrocytes; Single trial task; Chick; Memory; 18-α-Glycyrrhetinic acid; Endothelin-1; Tolbutamide
Simultaneous HPLC determination of tolbutamide, phenacetin and their metabolites as markers of cytochromes 1A2 and 2C6/11 in rat liver perfusate
Keywords: تولوباتید; Cytochrome P450; Phenacetin; Paracetamol; Tolbutamide; 4-Hydroxytolbutamide; Rat; HPLC
Characterization of the binding of sulfonylurea drugs to HSA by high-performance affinity chromatography
Keywords: تولوباتید; Sulfonylurea drugs; Acetohexamide; Tolbutamide; Human serum albumin; High-performance affinity chromatography; Frontal analysis; Zonal elution; Competition studies; Drug–protein binding
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC–MS/MS—A high throughput approach to evaluate drug–drug interactions
Keywords: تولوباتید; Drug–drug interaction; P450; Tolbutamide; Omeprazole; Midazolam; Dextromethorphan; LC–MS/MS; Incurred sample reproducibility (ISR)
Inhibition of ATP-sensitive potassium channels increases HSV-tk/GCV bystander effect in U373 human glioma cells by enhancing gap junctional intercellular communication
Keywords: تولوباتید; Connexin; Tolbutamide; Tumor; Sulfonylurea; Gap junctions; CNSCx43, connexin43; DAPI, 4′,6-diamidino-2-phenylindole; DMEM, Dubelcco’s modified Eagle’s medium; EtdBr, ethidium bromide; FCS, fetal calf serum; GCV, ganciclovir; GAPDH, glyceraldehyde-3-phosph
Conformational Polymorphism of Tolbutamide: A Structural, Spectroscopic, and Thermodynamic Characterization of Burger's Forms I-IV
Keywords: تولوباتید; Tolbutamide; polymorphism; crystal structure; stability; X-ray powder diffractometry; thermal analysis; anisotropic lattice contraction; energy-temperature diagram; density rule; lattice energy;
Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant
Keywords: تولوباتید; Micellar electrokinetic chromatography; Antihyperglycemic drug; Antidiabetic drug; Gliclazide; Glibenclamide; Glimepiride; Glipizide; Repaglinide; Tolbutamide; Non-ionic surfactant; Genapol X-080; Triton X-114 (reduced); On-line preconcentration
Reevaluation of solubility of tolbutamide and polymorphic transformation from Form I to unknown crystal form
Keywords: تولوباتید; Tolbutamide; Polymorphic transformation; Structure determination from PXRD data; Solid-state NMR
Equine cytochrome P450 2C92: cDNA cloning, expression and initial characterization
Keywords: تولوباتید; CYP450; Horse; CYP2C; Diclofenac; Mephenytoin; Tolbutamide; Warfarin; Phase I metabolism
Influence of chalcone analogues on serum glucose levels in hyperglycemic rats
Keywords: تولوباتید; Chalcone; Hyperglycemia; Analogues; Insulin; Tolbutamide;
Antagonism of the insulinotropic action of first generation imidazolines by openers of KATP channels
Keywords: تولوباتید; KATP channels, ATP-dependent K+ channels; [Ca2+], cytosolic calcium concentrationPancreatic islets; B-cells; Cytosolic calcium concentration; KATP channel; Efaroxan; Imidazolines; Tolbutamide
Effect of ethanolic extracts of Ananas comosus L. leaves on insulin sensitivity in rats and HepG2
Keywords: تولوباتید; Ananas comosus L.; Pineapple; Fenofibrate; Insulin resistance; Metformin; Tolbutamide; Type 2 diabetes; Glycogen; High-fat diets
Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions
Keywords: تولوباتید; CYP, cytochrome P450; TB, tolbutamide; PT, paclitaxel; DF, diclofenac; S-MP, S-mephenytoin; G-6-P, glucose 6-phosphateMarmoset; CYP2C8; Yeast cell; Tolbutamide; Quercetin
Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide
Keywords: تولوباتید; KATP channels; adenosine triphosphate-sensitive potassium channels; PKA; protein kinase A; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; Clonal pancreatic β-cells; Insulin release; KATP channels; Diazoxide; Nateglinide; Tolbutamide;
Pharmacological evidence for the activation of Ca2+-activated K+ channels by meloxicam in the formalin test
Keywords: تولوباتید; Meloxicam; Antinociception; K+ channels; Apamin; Charybdotoxin; 4-aminopyridine; Tetraethylammonium; Glibenclamide; Tolbutamide; Formalin test;
Nateglinide, a non-sulfonylurea rapid insulin secretagogue, increases pancreatic islet blood flow in rats
Keywords: تولوباتید; Oral hypoglycemic agent; Tolbutamide; Nitric oxide; Microsphere; Regional blood flow; Otsuka Long-Evans Tokushima Fatty rat;
Changes in muscle mRNAs for hexokinase, phosphofructokinase-1 and glycogen synthase in acute and persistent hypoglycemia induced by tolbutamide in chickens
Keywords: تولوباتید; Hypoglycemia; Tolbutamide; Chicken; Hexokinase (HK); Phosphofructokinase-1 (PFK-1); Glycogen synthase (GS); mRNA;
Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for their Modes of Action in Hair Follicles
Keywords: تولوباتید; bioassay; diazoxide; glibenclamide; minoxidil; NNC 55-0118; organ culture; phenol red; tolbutamide;
Probable activation of the opioid receptor-nitric oxide-cyclic GMP-K+ channels pathway by codeine
Keywords: تولوباتید; Codeine; Nitric oxide; Cyclic GMP; K+ channels; Opioid receptors; Naloxone; Glibenclamide; Tolbutamide; Formalin test;
The increase in gap junctional communication decreases the rate of glucose uptake in C6 glioma cells by releasing hexokinase from mitochondria
Keywords: تولوباتید; Neurotransmitters, modulators, transporters, and receptors; Uptake and transporters; tolb; tolbutamide; dbcAMP; 2â²-O-dibutyryladenosine 3â²:5â²-cyclic monophosphate; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; EGFR; epidermal grow
Crystal forms of tolbutamide from acetonitrile and 1-octanol: effect of solvent, humidity and compression pressure
Keywords: تولوباتید; Tolbutamide; Solvent; Polymorph; Humidity; Pressure; Drug release;