QT Prolongation and Oncology Drug Development
Keywords: QT prolongation; Cardiotoxicity; Cardio-oncology; Chemotherapy; Cancer treatment; Torsades de pointes;
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Summary of the 2014 ESC guidelines on non-cardiac surgery: Cardiovascular assessment and management
Keywords: AAA; abdominal aortic aneurysm; ACEI; angiotensin converting enzyme inhibitor; ACS; acute coronary syndromes; AF; atrial fibrillation; ARB; angiotensin receptor blocker; BMS; bare-metal stent; BNP; B-type natriuretic peptide; CABG; coronary artery bypass
Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
Keywords: Flecainide; hERG; QT interval; Repolarization; Torsades de Pointes;
Sudden Cardiac Death and Disorders of the QT Interval: Anesthetic Implications and Focus on Perioperative Management
Keywords: QT interval; long QT syndrome; short QT syndrome; torsades de pointes; magnesium; pacemaker; automated implanted cardiac defibrillator; transmural repolarization; cardiac ion channelopathy; Brugada syndrome; voltage-gated sodium channel; Bazett formula; b
Pacing-induced torsades de pointes after the short-long-short sequence in a patient with a biventricular defibrillator: What is the mechanism?
Keywords: AS; atrial sensing; AV; atrioventricular; CRT; cardiac resynchronization therapy; Inh; inhibiting; LV; left ventricular/ventricle; LVEF; left ventricular ejection fraction; LVP; left ventricular pacing; LVS; left ventricular sensing; LVPP; left ventricle
The effects of six antipsychotic agents on QTc-An attempt to mimic clinical trial through simulation including variability in the population
Keywords: Long QT; Torsades de Pointes; Simulation; Drugs; Ionic channels; Variability;
Electrophysiological Basis of ECG Characteristics of Torsades de Pointes in Long QT Syndrome
Keywords: Long QT syndrome; Torsades de pointes; Dispersion of repolarization; Bigeminal rhythm; T-wave alternans; Mapping;
A public-private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee
Keywords: ADRs; adverse drug reactions; CDER; Center for Drug Evaluation and Research; cTn; cardiac troponin; CV; cardiovascular; EMA; European Medicines Agency; EWG; Expert Working Group; ECG; electrocardiogram; HESI; Health and Environmental Sciences Institute; h
Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
Keywords: AP (D); Action Potential (Duration); ECG; electrocardiogram; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; hERG; human-Ether-a-go-go Related Gene; IC50; Concentration for
A history of the role of the hERG channel in cardiac risk assessment
Keywords: hERG; human ether-a-go-go-related gene; TdP; torsades de pointes; TQT; thorough QT trial; Agonists; Blockers; hERG; Methods; Modeling; Patch clamp; Trafficking;
Oxaliplatin-induced acquired long QT syndrome with torsades de pointes and myocardial injury in a patient with dilated cardiomyopathy and rectal cancer
Keywords: coronary vasospasm; hypersensitivity; long QT syndrome; oxaliplatin; torsades de pointes
QT prolongation and torsades de pointes during emergency treatment with nifekalant for refractory ventricular tachyarrhythmias: Post-hoc analysis from a large-scale multicenter post-marketing survey in Japan
Keywords: Nifekalant; Class III antiarrhythmic drug; Life-threatening ventricular arrhythmia; QT prolongation; Torsades de pointes
Drug-drug interactions contributing to QT prolongation in cardiac intensive care units
Keywords: Intensive care units; Drug interactions; Cardiac arrhythmias; Torsades de pointes; Patient safety
Methadone, QTc prolongation and torsades de pointes: Current concepts, management and a hidden twist in the tale?
Keywords: Methadone; Pharmacogenetics; QT-prolongation; Torsades de pointes;
The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias
Keywords: Antiarrhythmic; Lambeth Conventions; Methods; Supraventricular arrhythmia; Torsades de pointes; Ventricular arrhythmia
Acute Indoramin Poisoning: a Review of 55 Cases Reported to the Paris Poison Centre from 1986 to 2010
Keywords: seizures; dysrhythmias; ECG changes; QT; drug induced long QT syndrome; torsades de pointes; overdose; acute poisoning; indoramin; convulsions; troubles du rythme; modifications ECG; QT; syndrome QT d'origine médicamenteuse; torsades de pointes; surdos
Clinical characteristics of 30 Czech families with long QT syndrome and KCNQ1 and KCNH2 gene mutations: importance of exercise testing
Keywords: Exercise test; LQT syndrome; Mutation; Sudden cardiac death; Torsades de Pointes
The Telemetric and Holter ECG Warehouse (THEW): The first three years of development and research
Keywords: Database; ECG/EKG; Electrocardiogram; Cardiac safety; QT; Long QT syndrome; Acute myocardial infarction; Coronary syndrome; Acute myocardial infarction; Thorough QT studies; Healthy normal; Torsades de pointes; Clinical trials
Ranolazine stabilizes cardiac ryanodine receptors: A novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2
Keywords: Ranolazine; Action potential durations; Cycle length; Early afterdepolarizations; Torsades de pointes; Long QT type 2; Intracellular free calcium; Sarcoplasmic reticulum; Cardiac ryanodine receptor; Open probability; Shannon-Puglisi model; Mahajan UCLA mo
Diagnostic Evaluation of Long QT Syndrome
Keywords: Long QT syndrome; Provocative testing; Torsades de pointes; Holter recording;
Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo
Keywords: Short-term variability; Torsades de pointes; Chronic AV block dog; Drugs; Long QT syndrome; Repolarization; Biomarkers; APD; action potential duration; BVR; beat-to-beat variability of repolarization; cAVB; chronic atrioventricular block; ECG; electrocard
Metabolic stress, reactive oxygen species, and arrhythmia
Keywords: âΨm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5â²-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI
Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog
Keywords: Arrhythmias; Calcineurin; CaMKII; Chronic AV block dog; Ventricular remodeling; ANP; atrial natriuretic peptide; APD; action potential duration; CaMKII; calcium/calmodulin-dependent protein kinase II; CAVB; chronic AV block; CnA; calcineurin-A; CSA; cyc
Adverse Effects and Toxicity of the Atypical Antipsychotics: What Is Important for the Pediatric Emergency Medicine Practitioner?
Keywords: atypical antipsychotics; extrapyramidal syndromes (EPS); neuroleptic malignant syndrome; QTc prolongation; torsades de pointes
Rosuvastatin Blocks hERG Current and Prolongs Cardiac Repolarization
Keywords: potassium current; cardiac repolarization; drugs; long QT syndrome; torsades de pointes;
Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome
Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm
Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers
Keywords: Electrocardiography; Ion channels; Obesity; Pharmacology; QT interval; BMI; body mass index; ECG; electrocardiogram; TdP; torsades de pointes;
Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes
Keywords: Stress cardiomyopathy; Takotsubo; Torsades de pointes; Long QT syndrome; Ventricular fibrillation; Ventricular tachycardia; Sudden cardiac deathCI, confidence interval; ECG, electrocardiographic; SCM, stress cardiomyopathy; ICD, implantable cardioverter-d
Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit
Keywords: Rabbit; QT; QT interval prolongation; QT interval variability; Torsades de pointes
A novel mechanism for LQT3 with 2:1 block: A pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation
Keywords: Cardiac Sodium Channel; LQT3; V411M; Flecainide; Mexiletine; Lidocaine; WT; wild-type; LQTS; Long QT Syndrome; AP; action potential; ECG; electrocardiogram; GOF; gain of function; HEK; human embryonic kidney; TdP; torsades de pointes;
Infrasensado auricular intermitente de marcapasos VDD en pacientes con repolarización sensible a bradicardia: un potencial mecanismo de arritmias ventriculares
Keywords: Torsade de pointes; Infradetección auricular; Estimulación VDD; Intervalo QT prolongado; Bloqueo AV completo; Torsades de pointes; Atrial undersensing; VDD pacing; QT-interval prolongation; Complete atrioventricular block;
Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine
Keywords: Arrhythmias; Desipramine; hERG channel; LQT; Rapidly-activating delayed rectifier K+ current; Torsades de pointes; Tricyclic antidepressant
A unique digital electrocardiographic repository for the development of quantitative electrocardiography and cardiac safety: the Telemetric and Holter ECG Warehouse (THEW)
Keywords: Database; ECG; Electrocardiogram; Cardiac safety; QT; Long QT syndrome; Acute myocardial infarction; Coronary syndrome; Acute myocardial infarction; Thorough QT studies; Healthy normal; Torsades de pointes
Torsades: adjacent and triggering electrocardiographic events
Keywords: Torsades de pointes; Adjacent ECG events; Triggering ECG events; Pause-dependent T wave augmentation; Acquired long QT syndrome
Early afterdepolarizations and cardiac arrhythmias
Keywords: Afterdepolarization; Arrhythmia; Chaos synchronization; Computer modeling; Nonlinear dynamics; Sudden cardiac death; Systems biology; Torsades de pointes; Triggered activityAP, action potential; APD, action potential duration; DI, diastolic interval; EAD,
Uni- or bi-ventricular hypertrophy and susceptibility to drug-induced torsades de pointes
Keywords: Hypertrophy; Methods; Rabbits; Torsades de pointes
Efficacia e tossicità della terapia farmacologica per il controllo del paziente acutamente agitato (I parte)
Keywords: Agitation; Psychiatric emergency; Rapid tranquilization; Torsades de pointes; QT interval;
Beyond the safety assessment of drug-mediated changes in the QT interval… what's next?
Keywords: Safety Pharmacology; FDA; Torsades de pointes; Short QT syndrome; Jacketed external telemetry
Torsades de Pointes with QT prolongation related to donepezil use
Keywords: Donepezil; Torsades de Pointes; QT prolongation
Structural determinants for histamine H1 affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs
Keywords: Antihistamine; Terfenadine; Astemizole; Torsades de pointes; hERG; H1
The QT interval: Too long, too short or just right
Keywords: Long QT syndrome; Short QT syndrome; Torsades de pointes; Ventricular fibrillation;
Does the sedative agent, JM-1232(â) cause QT prolongation with subsequent torsades de pointes?
Keywords: JM-1232(â); QT prolongation; Torsades de pointes; MAP triangulation; Telemetry; Langendorff;
Measuring the risk of torsades de pointes: Electrocardiographic evaluation of PNU-142093 in conscious cynomolgus non-human primates using restraint and non-restraint procedures
Keywords: Safety Pharmacology; Torsades de Pointes; QT and QTc interval; Cardiovascular toxicity; Arrhythmia; ICH S7A and S7B; Non-human primate; Cardiac ventricular repolarization
Role of Mg2+ block of the inward rectifier K+ current in cardiac repolarization reserve: A quantitative simulation
Keywords: AP; action potential; SPM; spermine; SPD; spermidine; APD; action potential duration; EAD; early afterdepolarization; LQTS; Long QT syndrome; TdP; torsades de pointes; Potassium channels; Action potentials; Long-QT syndrome; Arrhythmia; Computer model;
Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: Evidence for clinically significant IKr-IKs α-subunit interaction
Keywords: Long QT syndrome; KCNQ1; KCNH2; Torsades de pointes; Sudden cardiac deathAU, arbitrary units; CHO, Chinese hamster ovary; dn, dominant negative; ER, endoplasmic reticulum; E1, KCNE1; HEK, human embryonic kidney; H2, KCNH2; LQTS, long QT syndrome; OD, opti
Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative
Keywords: APD; action potential duration; APD90; APD at 90% repolarization; APD30-90; APD between 30% and 90% repolarization; APD30-60; APD between 30% and 60% repolarization; AV; atrioventricular; EC10; effective concentration producing 10% changes; IKr; rapid
Chronic Methadone Therapy Complicated by Torsades De Pointes: A Case Report
Keywords: torsades de pointes; methadone; cardiac toxicity; implantable cardioverter-defibrillator; drug toxicity
Beat-to-beat variability of repolarization differentiates the extent of torsadogenic potential of multi ion channel-blockers bepridil and amiodarone
Keywords: Bepridil; QT interval prolongation; Torsades de pointes; Beat-to-beat variability of repolarization; Chronic atrioventricular block dog
Torsades de pointes related to transient marked QT prolongation following successful emergent percutaneous coronary intervention for acute coronary syndrome
Keywords: Torsades de Pointes; Acute coronary syndrome; Long QT syndrome; T-wave peak to T-wave end interval; Transmural dispersion of repolarization;
Clomipramine block of the hERG K+ channel: Accessibility to F656 and Y652
Keywords: Arrhythmia; Clomipramine; hERG channel; LQT; Rapidly activating delayed rectifier K+ current; Torsades de pointes; Tricyclic antidepressant;