Use of the rabbit with a failing heart to test for torsadogenicity
Keywords: Heart failure; QT; Rabbit; Torsadogens; Torsades de pointes
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Investigating the effect of sotalol on the repolarization intervals in healthy young individuals
Keywords: QT interval; Torsades de pointes; Long QT syndrome; Sotalol; Vectocardiography; ECG
The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes
Keywords: Torsades de pointes; Long QT syndrome; Proarrhythmias; Drugs; Rabbit; α-Adrenergic stimulationTdP, torsades de pointes; IKr, rapid component of the delayed rectifying potassium current
Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method
Keywords: Electrocardiogram; Restitution; Torsades de pointes; Arrhythmia; Autonomic tone; Translation to humansBPM, beats per minute; ECG, electrocardiogram; IKr, rapid potassium delayed rectifier current; IKs, slow potassium delayed rectifier current; PK, pharmac
Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method
Keywords: Electrocardiogram; Restitution; Torsades de pointes; Arrhythmia; Autonomic tone; Translation to humans; BPM; beats per minute; ECG; electrocardiogram; IKr; rapid potassium delayed rectifier current; IKs; slow potassium delayed rectifier current; PK; pharm
Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3
Keywords: Na+/Ca2+ exchanger; Torsades de pointes; Long QT syndrome; Early afterdepolarizations; SEA0400;
The canine model with chronic, complete atrio-ventricular block
Keywords: AV; Atrio-ventricular; AAVB; Acute complete atrio-ventricular block; BVR; Beat-to-beat variability of repolarization; CAVB; Chronic complete atrio-ventricular block; CAVBr; CAVB resistant to drug-induced TdP; CAVBs; CAVB susceptible to drug-induced TdP; D
Model systems for the discovery and development of antiarrhythmic drugs
Keywords: Arrhythmias; Ion channel blockers; Ion currents; Reentry; AF; atrial fibrillation; APD; action potential duration; CAVB; chronic atrio-ventricular block; CHF; congestive heart failure; DAD; delayed afterdepolarization; EAD; early afterdepolarization; hERG
The hERG K+ channel: target and antitarget strategies in drug development
Keywords: HERG K+ channels; QT interval; Torsades de pointes; Arrhythmia; Drug development
Points to consider emerging from a mini-workshop on cardiac safety: Assessing torsades de pointes liability
Keywords: QT interval; Safety pharmacology; Torsades de Pointes; Cardiovascular; Arrhythmia
QTc Prolongation and Torsades de Pointes Associated with Methadone Therapy
Keywords: methadone; QTc prolongation; Torsades de Pointes; HIV; dysrhythmia
Acquired long QT syndrome: Long-term electrocardiographic (Holter) recording of Torsades de Pointes ending in asystole: II
Keywords: Torsades de Pointes; Spiral wave reentry; Holter recording
Acquired long QT syndrome: Risperidone-facilitated triggered activity and Torsades de Pointes during complete AV block. I
Keywords: Acquired Long QT Syndrome; Torsades de Pointes; Risperidone
Further evidence of inherited long QT syndrome gene mutations in antiarrhythmic drug–associated torsades de pointes
Keywords: LQTS; Torsades de pointes; Proarrhythmia; Amiodarone; Ion-channel mutation
Torsades de pointes complicating atrioventricular block: Evidence for a genetic predisposition
Keywords: Atrioventricular block; Long QT interval; Torsades de pointes; HERG mutation
Coinheritance of long QT syndrome and Kearns-Sayre syndrome
Keywords: Kearns-Sayre syndrome; Mitochondrial disorder; Long QT syndrome mutation; Torsades de pointes; Complete atrioventricular block;
Arrhythmias associated with fluoroquinolone therapy
Keywords: Proarrhythmia; QT prolongation; Torsades de pointes; Ciprofloxacin; Ofloxacin; Levofloxacin; Gemifloxacin; Moxifloxacin
K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization
Keywords: K201 (JTV-519); Multi-channel blocker; Clofilium; α1-Adrenoceptor blocker; QT interval prolongation; Torsades de pointes;
Animal models of ventricular arrhythmias
Keywords: Models; Torsades de pointes; Arrhythmia; Drug-induced
Torsades de Pointes precoces y elevación sérica de la troponina I debidas a intoxicación aguda por arsénico
Keywords: intoxicación aguda por arsénico; trioxide de arsénico; miocarditis; intervalo QT largo; torsades de Pointes; hipopotasemia; hipomagnesemia; shock vasoplégico; acute arsenic poisoning; arsenic trioxide; myocarditis; long interval QT; torsades de Pointe
Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval
Keywords: QT interval; Torsades de pointes; Corrected QT interval; Drug development
Torsades de pointes induced by antibiotics
Keywords: QT interval; Torsades de pointes; Antibiotic
Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block
Keywords: Antiarrhythmic drugs; Torsades de pointes; Atrial-specific drugs; Chronic complete atrioventricular block; Short-term variability of repolarization
QT long acquis : un problème envahissant ?
Keywords: Intervalle QT; QT long acquis; Torsades de pointes; Effets secondaires des médicaments; Traitement du QT long; QT interval; Acquired long; QT syndrome; Torsades de pointes; Drugs side effects; Treatment of long; QT syndrome;
Dental treatment of patients with long QT syndrome
Keywords: QT prolongation; long QT syndrome; torsades de pointes; syncope; dental procedures; stress
Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel
Keywords: Antihistamine; Arrhythmia; Clemastine; HERG; QT interval; QT-prolongation; Rapid delayed rectifier; Torsades de pointes
Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel
Keywords: hERG; 3H-dofetilide; Binding assay; Membrane potential dye; QT prolongation; Arrhythmias; Rubidium efflux; Torsades de Pointes
Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends
Keywords: Action potential; Channel/receptor crosstalk; Gene expression; hERG channel; In silico models; In vitro models; In vivo models; QT interval; Torsades de Pointes
Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias
Keywords: AP; action potential; IC50; concentration at 50% inhibition; TdP; torsades de pointes; Ventricular arrhythmias; Guidelines; IKr; Drug effects; QT prolongation; Repolarisation;
Kearns-Sayre syndrome associated with trifascicular block and QT prolongation
Keywords: Kearns-Sayre syndrome; Conduction abnormalities; Trifascicular block; Long QT; Torsades de pointes; Diabetes mellitus;
Mechanisms underlying arrhythmogenesis in long QT syndrome
Keywords: Long QT syndrome; Arrhythmogenesis; Torsades de pointes;
SÃndrome de QT largo adquirido en pacientes ingresados en UCI
Keywords: sÃndrome de QT largo; torsades de Pointes; etiologÃa; tratamiento; fármacos; long QT syndrome; torsade de Pointes; etiology; treatment; drugs;
Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes
Keywords: Long QT syndrome; Torsades de pointes; Transmural dispersion of repolarization; Arterially perfused wedge; Arrhythmia; Arrhythmogenesis; Antiarrhythmia agents;
Use of preclinical assays to predict risk of drug-induced torsades de pointes
Keywords: Long QT syndrome; Torsades de pointes; Electrophysiology; Arrhythmia; Arrhythmogenesis; Antiarrhythmia agents; Drug development;
Clinical trial design to evaluate the effects of drugs on cardiac repolarization: Current state of the art
Keywords: Long QT syndrome; Torsades de pointes; Arrhythmia; Drug development; Trial design; Fluoroquinolones; Ziprasidone; QT interval correction;
Drug-induced proarrhythmia and use of QTc-prolonging agents: Clues for clinicians
Keywords: Arrhythmia; Clinical practice; Drug; QT interval; QTc interval; Torsades de pointes;
Drug-induced torsades de pointes: The evolving role of pharmacogenetics
Keywords: HERG potassium channel; Long QT syndrome; Pharmacogenomics; Pharmacogenetics; Torsades de pointes; Polymorphisms; Ion channels;
Nonclinical proarrhythmia models: Predicting Torsades de Pointes
Keywords: AP; Action potential; APD; Action potential duration; APD90; Action potential duration at 90% repolarization; A-V; Atrioventricular; CAVB; Chronically A-V block; CV; Conduction velocity; EADs; Early after-depolarizations; ECG; Electrocardiogram; hERG; Hum
Refining detection of drug-induced proarrhythmia: QT interval and TRIaD
Keywords: Dispersion of repolarization; Instability of repolarization; Proarrhythmia; QT prolongation; Reverse use dependency; Torsades de pointes; Triangulation of action potential; TRIaD;