Keywords: Biotin; Interference; Sandwich immunoassay; Competitive immunoassay; HCG; human chorionic gonadotropin; PCT; procalcitonin; PTH; parathyroid hormone; hs-TnT; troponin; LH; luteinizing hormone; NT-proBNP; N-terminal pro-B-type natriuretic peptide; TSH; thy
مقالات ISI (ترجمه نشده)
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Keywords: prostate-specific antigen; prostatic neoplasms; transplantation; graft survival; cPSA; complexed PSA; ESLD; end stage liver disease; ESRD; end stage renal disease; fPSA; free PSA; HD; hemodialysis; MMF; mycophenolate mofetil; PSA; prostate specific antige
Keywords: AB-MECA; (N6-(4-aminobenzyl)-N-methylcarboxamidoadenosine); AC; adenylate cyclase; AR; adenosine receptor; CHO; Chinese Hamster Ovary; DPCPX; 8-cyclopentyl-1,3-dipropylxanthine; MV; molecular volume; NECA; 5â²-(N-ethylcarboxamido)adenosine; TPSA; Topolog
Keywords: Allosteric inhibition; PEF(S); Calpain-1 inhibitors; Structure-based design; Docking; PEF(S); penta-EF hand calcium binding domain; TNS; p-toluidinylnaphthalene-6-sulfonate; CysPc; calpain-like protease domain; kDa; kilo Dalton; SAR; structure activity re
Keywords: AD; Alzheimer's disease; NFT; neurofibrillary tangles; ChE; cholinesterase; NMDA; N-methyl-D-aspartate; TCM; Traditional Chinese Medicine; MOA; mechanisms of action; TCMSP; traditional Chinese medicine systems pharmacology; TCMID; traditional Chinese medi
Keywords: Ag@MSN; silver hybridized mesoporous silica nanoparticles; AFP; alpha-fetoprotein; APBA; 3-aminophenylboroic acid; APTES; 3-aminopropyltriethoxysilane; APTMS; aldehyde propyltrimethoxysilane; AuNPs@GMCs; graphitized mesoporous carbon-gold nanoparticles; B
Keywords: Curcumin (Pubchem CID:969516); Curcumin; Lipophilic drugs; Nanoparticles; Drug delivery; cur-intra; curcumin loaded intralipid; cur-LDL; curcumin loaded LDL; cur-lip; curcumin loaded liposomes; cur-mic; curcumin loaded polymeric micelles; EPR; enhanced pe
Keywords: Chemotaxis; Selection; Saccharide; TPSA; XLogP; TetrahymenaSEA, solvent exposed area; TPSA, topological polar surface area; XLogP, octanol/water partition coefficient
Keywords: ADME; absorption/distribution/metabolism/excretion; BBB; blood-brain barrier; CD3OD; tetradeuteromethanol; CDCl3; deuterochloroform; CH2Cl2; dichloromethane; C log D; distribution coefficient; C log P; calculated partition coefficient; CNS; central
Keywords: ATP; adenosine triphosphate; ADP; adenosine diphosphate; Cer; ceramide; ERK-1/2; extra-cellular signal-regulated kinase 1/2; HDAC; histone deacetylase; LDH; lactate dehydrogenase; S1P; sphingosine-1-phosphate; SAR; structure-activity relationship; Sph;
Keywords: %fPSA; ratio of fPSA to tPSA (in percent) also known as f/tPSA ratio or percent free PSA; %[â 2]proPSA; percentage of [-2]proPSA to fPSA; A2M; alpha2-macroglobulin; ACT; alpha-1-antichymotrypsin; ANN; artificial neural network; API; alpha1-protease inh
Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis
Keywords: Pinus elliottii; Dehydroabietic acid; Diterpene; Leishmanicidal activity; Cytotoxity; Resin acid; ACL; American cutaneous leishmaniasis; AMB; amphotericin B; CTLC; comparative thin layer chromatography; DMSO; dimethylsulfoxide; DHA; dehydroabietic acid; F
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity
Keywords: Dihydrofolate reductase (DHFR); Antimycobacterial agent; Tuberculosis (TB); 1,3,5-triazaspiro[5.5]undeca-2,4-diene; DHFR; dihydrofolate reductase; DMPK; drug metabolism and pharmacokinetics; FRLM; female rat liver microsomes; HBA; hydrogen bond acceptors;
Identification of small molecule activators for ErbB 4 receptor to enhance oligodendrocyte regeneration by in silico approach
Keywords: ADMET; adsorption distribution metabolism excretion toxicity; BBB; blood brain barrier; BS; bioavailability score; CNS; central nervous system; CT; C-terminal tail; ECD; extracellular domain; EGF; epidermal growth factor; ESOL; estimated solubility; EV; E
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile
Keywords: BA; bioavailability; RAAS; renin-angiotensin-aldosterone system; BP; blood pressure; Ang I; angiotensin I; ACE; Angiotensin-converting enzyme; Ang II; angiotensin II; AT1; Ang II type I receptor; DRI; direct renin inhibitor; TPSA; topological polar surfac
FilTer BaSe: A web accessible chemical database for small compound libraries
Keywords: ADMET; absorption distribution metabolism excretion and toxicity; MW; molecular weight; tPSA; topological polar surface area; PAINS; pan assay interference compounds; QASR; quantitative structure-activity relationship; Compound libraries; FilTer BaSe; V
Development of inhibitors of receptor protein tyrosine phosphatase β/ζ (PTPRZ1) as candidates for CNS disorders
Keywords: PTPRZ1; CNS disorders; Drug addiction; Molecular dynamics; Synthesis; EDCI; 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide; HOBt; hydroxybenzotriazole; MCPBA; meta-chloroperbenzoic acid; MK; Midkine; PAMPA-BBB; membrane permeability assay for the blood-bra
New hydrazine and hydrazide quinoxaline 1,4-di-N-oxide derivatives: In silico ADMET, antiplasmodial and antileishmanial activity
Keywords: ACTs; artemisinin-based combination therapies; QdNO; quinoxaline 1,4-di-N-oxide; SAR; structure-activity relationship; VL; virtual library; SI; selectivity index; TPSA; topological polar surface area; %ABS; human intestinal absorption; Malaria; Leishmania
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease
Keywords: AD; Alzheimer's disease; AChEIs; acetylcholinesterase inhibitors; NMDA; N-methyl-d-aspartate; Aβ; β-amyloid; Ï; tau protein; ACh; acetylcholine; MTDLs; multi-target-directed ligands; MAO-B; monoamine oxidase B; MAO-A; monoamine oxidase A; BuChE; buty
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Diverse amide analogs of sulindac for cancer treatment and prevention
Keywords: NSAID; non-steroidal anti-inflammatory drug; COX; cyclooxygenase; SSA; sulindac sulfide amide; SAR; structure-activity relationship; AA; amino acid; ALL; acute lymphoblastic leukemia; CPC; choroid plexus carcinoma; TPSA; topological polar surface area; Li
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design
Keywords: Phenyl [(phenylcarbamoyl)amino]benzene-1-sulfonate derivatives; N-Phenyl-[(phenylcarbamoyl)amino]benzene-1-sulfonamide derivatives; Fragment-linking strategy; Dengue virus; NS5 methyltransferase inhibitors; Antiviral activity; DENV; dengue virus; NS; non-
Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability
Keywords: In silico prediction; Dermal absorption; Modelling; Bioavailability; Risk assessment; Cosmetic ingredient; Physicochemical properties; Safety evaluation; A; daily amount of product exposed to per kg body weight; CDK; Chemistry Development Kit; DA; dermal
Retention data of bile acids and their oxo derivatives in characterization of pharmacokinetic properties and in silico ADME modeling
Keywords: logP; logarithm of partition coefficient; RM0; intercept; b; slope of the linear plot; C; volume fraction of the organic solvent in the mobile phase; TPSA; total polar surface area; natoms; number of atoms; Mw; molecular weight; nOH; number of hydrogen bo
Efficient access to sp3-rich tricyclic amine scaffolds through Diels-Alder reactions of azide-containing silyloxydienes
Keywords: Parallel synthesis; Diels-Alder cycloaddition; Polycyclic heterocycles; PTSA; para-toluenesulfonic acid; NP; natural product; Fsp3; fraction sp3; HBD; hydrogen bond donors; HBA; hydrogen bond acceptors; tPSA; topological polar surface area; rotB; rotata
Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2
Keywords: 4-Phenylpyrimidine-2(1H)-thiones; Inhibition of cyclooxygenases; BCS; biopharmaceutics classification system; CH3OH; methanol; COX; cyclooxy-genase; DMSO; dimethylsulfoxide; EDTA; ethylenediaminetetraacetic acid; EIA; enzyme immuno assay; ELISA; enzyme li
Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours
Keywords: 1H NMR; Proton nuclear magnetic resonance; AO; Acridine orange; CMC; Critical micellar concentration; cRGDfK; Cyclo(-Arg-Gly-Asp-D-Phe-Lys); DMEM; Dulbecco's modified eagle medium; DMSO; Dimethyl sulfoxide; DNM; Docetaxel loaded TPSA nanomicelles; DPBS;
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes
Keywords: Peptidomimetics; Anti-inflammatory; Anti-hyperalgesic; COX-2; 5-LOX inhibitors; ACN; acetonitrile; COX; cyclooxygenase; LOX; lipoxygenase; SAID; steroidal anti-inflammatory drugs; NSAID; non-steroidal anti-inflammatory drugs; COXIBS; selective cyclooxygen
Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines
Keywords: Chemotype sensitivity; Cytotoxicity assay; THLE; HepG2; ATP depletion assay; Exploratory Toxicology Studies; c Log P; TPSA
The Roles of Multiparametric Magnetic Resonance Imaging, PCA3 and Prostate Health Index-Which is the Best Predictor of Prostate Cancer after a Negative Biopsy?
Keywords: prostatic neoplasms; biopsy; magnetic resonance imaging; prostate cancer antigen 3; human; bGS; biopsy Gleason score; DCA; decision curve analysis; DRE; digital rectal examination; DWI; diffusion weighted imaging; %fPSA; free PSA rate; mp-MRI; multiparame
Development of tag-free photoprobes for studies aimed at identifying the target of novel Group A Streptococcus antivirulence agents
Keywords: SK; streptokinase; GAS; Group A Streptococcus; HTS; high-throughput screen; SAR; structure-activity relationship; TPSA; topological polar surface area; c Log P; logarithm of the calculated octanol-water partition coefficient; LDA; lithium diisopropy
Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e PrÃncipe
Keywords: Aβ; amyloid beta peptide; AD; Alzheimer׳s disease; APP; amyloid precursor protein; ATP; adenosine triphosphate; BBB; blood-brain barrier; CLogP; lipophilicity; CNS; Central nervous system; DMEM; Dulbecco׳s modified Eagle׳s medium; ESI; Electrospray
Conserved water mediated H-bonding dynamics of Ser117 and Thr119 residues in human transthyretin-thyroxin complexation: Inhibitor modeling study through docking and molecular dynamics simulation
Keywords: hTTR; human transthyretin; T4; thyroxin; CSF; cerebrospinal fluid; RBP; retinol-binding protein; FAC; familial amyloid cardiomyopathy; SSA; senile systemic amyloidosis; FAP; familial amyloidotic polyneuropathy; HBP; halogen binding pocket; Mod; modified;
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: Carboxamide derivatives with different spacer motifs
Keywords: BBB; blood-brain barrier; CD3OD; tetradeuteromethanol; CDCl3; deuterochloroform; CH2Cl2; dichloromethane; CNS; central nervous system; D2O; deuterium oxide; DCC; N,Nâ²-dicyclohexylcarbodiimide; DMAP; 4-(dimethylamino)pyridine; DME; 1,2-dimethoxyethane;
Predicting prostate biopsy outcome: prostate health index (phi) and prostate cancer antigen 3 (PCA3) are useful biomarkers
Keywords: phi; prostate health index; PCA3; prostate cancer antigen 3; PSA; prostate-specific antigen; DRE; digital-rectal examination; tPSA; total PSA; fPSA; free PSA; p2PSA; [â 2]proPSA; f/t PSA; free/total PSA; HGPIN; high grade prostatic intraepithelial neop
Association of [â2]proPSA with Biopsy Reclassification During Active Surveillance for Prostate Cancer
Keywords: prostate-specific antigen; prostatic neoplasms; biopsy; watchful waiting; fPSA; free PSA; phi; Beckman Coulter Prostate Health Index; proPSA; proenzyme PSA; PSA; prostate specific antigen; tPSA; total PSA;
Glycosylation of prostate specific antigen and its potential diagnostic applications
Keywords: 2-DE; two-dimensional electrophoresis; AA(A); Aleuria aurantia agglutinin; AMACR; α-methylacyl-CoA racemase; BPH; benign prostatic hyperplasia; BPSA; benign prostatic hyperplasia associated PSA; Con A; Concanavalin A; CE; capillary electrophoresis; ELLA;
Value of Prostate Specific Antigen Density and Percent Free Prostate Specific Antigen for Prostate Cancer Prognosis
Keywords: prostatic neoplasms; prognosis; BCR; biochemical recurrence; BCR-FS; biochemical recurrence-free survival; fPSA; free prostate specific antigen; %fPSA; percent free prostate specific antigen; KLK2; kallikrein 2; LRP; laparoscopic radical prostatectomy; NS
Association Between Smoking Status, and Free, Total and Percent Free Prostate Specific Antigen
Keywords: prostatic neoplasms; smoking; prostate-specific antigen; early detection of cancer; %fPSA; percent free prostate specific antigen; BMI; body mass index; BPH; benign prostatic hyperplasia; fPSA; free prostate specific antigen; NSAIDs; nonsteroidal anti-inf
Development and Internal Validation of a Prostate Health Index Based Nomogram for Predicting Prostate Cancer at Extended Biopsy
Keywords: prostate; prostate-specific antigen; nomograms; prostatic neoplasms; biopsy; DCA; decision curve analysis; DRE; digital rectal examination; fPSA; free PSA; f/tPSA; free-to-total PSA; p2PSA; [-2]proPSA; PCa; prostate cancer; PCA3; prostate cancer antigen
Serum Index Test %[-2]proPSA and Prostate Health Index are More Accurate than Prostate Specific Antigen and %fPSA in Predicting a Positive Repeat Prostate Biopsy
Keywords: prostate-specific antigen; prostatic neoplasms; biopsy; early detection of cancer; diagnosis; DCA; decision curve analysis; DRE; digital rectal examination; fPSA; free prostate specific antigen; %fPSA; free/total prostate specific antigen; PCa; prostate c
Effectiveness of the Combined Evaluation of KLK3 Genetics and Free-to-Total Prostate Specific Antigen Ratio for Prostate Cancer Diagnosis
Keywords: prostate; prostatic neoplasms; prostate-specific antigen; 3-oxo-5-alpha-steroid 4-dehydrogenase; polymorphism; genetic; DHT; dihydrotestosterone; f/tPSA; free-to-tPSA ratio; LR; likelihood ratio; NPV; negative predictive value; PCa; prostate cancer; PPV;
The contribution of physicochemical properties to multiple in vitro cytotoxicity endpoints
Keywords: pKa; clogP; TPSA; High content screening; Multiple toxicity endpoints;
How hydrogen bonds impact P-glycoprotein transport and permeability
Keywords: Hydrogen bond; Intramolecular hydrogen bond; P-Glycoprotein; Permeability; HBA; HBD; TPSA; ATP-binding cassette;
Using an in vitro cytotoxicity assay to aid in compound selection for in vivo safety studies
Keywords: c log P; Toxicology; TPSA; Attrition; Cytotoxicity; Physico chemistry
Effectiveness of Antibiotics Given to Asymptomatic Men for an Increased Prostate Specific Antigen
Keywords: prostate-specific antigen; anti-bacterial agents; prostatic neoplasms; CP/CPPS; chronic prostatitis/chronic pelvic pain syndrome; DRE; digital rectal examination; EPS; expressed prostatic secretion; fPSA; free prostate specific antigen; %fPSA; percent fre
A Framework for the Identification of Men at Increased Risk for Prostate Cancer
Keywords: prostatic neoplasms; risk factors; prostate-specific antigen; biological markers; early detection of cancer; %fPSA; percent free PSA; ASAP; atypical small acinar proliferation; BLSA; Baltimore Longitudinal Study of Aging; DRE; digital rectal examination;
Total Prostate Specific Antigen Stability Confirmed After Long-Term Storage of Serum at â80C
Keywords: prostate; prostate-specific antigen; freezing; serum; ACT; antichymotrypsin; CV; coefficient of variation; fPSA; free PSA; PSA; prostate specific antigen; SABOR; San Antonio Center of Biomarkers of Risk for Prostate Cancer; tPSA; total PSA;
Prostate Specific Antigen Isoforms and Human Glandular Kallikrein 2-Which Offers the Best Screening Performance in a Predominantly Black Population?
Keywords: prostate-specific antigen; prostatic neoplasms; African Americans; mass screening; AUC; area under the curve; cPSA; complexed prostate specific antigen; DRE; digital rectal examination; fPSA; free prostate specific antigen; hK2; human glandular kallikrein
Adenocarcinoma of the Prostate: Epidemiological Trends, Screening, Diagnosis, and Surgical Management of Localized Disease
Keywords: ACT; a1-antichymotrypsin; BPH; benign prostatic hyperplasia; cPSA; complexed PSA; DRE; digital rectal examination; fPSA; free PSA; PIN; prostatic intraepithelial neoplasia; PSA; prostate-specific antigen; RRP; radical retropubic prostatectomy; tPSA; total