Keywords: Aβ; amyloid-β-peptide; ACh; acetylcholine; Apo; apolipoprotein; APP; amyloid precursor protein; CYP; cytochrome P-450; DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1A; GABA; γ-aminobutyric acid; GSK; glycogen synthase- kinase; HSV-
مقالات ISI (ترجمه نشده)
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Keywords: Traumatic brain injury; Alzheimer's disease; Neuroinflammation; Neurodegeneration; Blood-brain barrier; Microglia; Macrophages; Astrocytes; TREM2;
Keywords: Aβ1-42; 42-amino acid-long Aβ peptide; AD; Alzheimer's disease; ADAPT; Alzheimer's Disease Anti-Inflammatory Prevention Trial; ADAS-Cog; Alzheimer's Disease Assessment Scale-Cognitive Subscale; ADCS-ADL; Alzheimer's Disease Cooperative Study Activ
Keywords: ABC; ATP-binding cassette; ABCA; ABC subfamily A; AD; Alzheimer's disease; ApoE; apolipoprotein E; APP; amyloid precursor protein; Aβ; amyloid-β; BBB; blood-brain barrier; DAMPs; damage-associated molecular patterns; HDL; high-density lipoprotein; HFD
Keywords: Microglia; Stress; Alzheimer's disease; Neurodegeneration; Neuroinflammation; Synaptic remodeling; Microglial phenotypes; Dark microglia; Aβ; Amyloid beta; ABCA7; ATP-binding cassette transporter A7; AD; Alzheimer's disease; APOE; Apolipoprotein E; APP;
Keywords: DDRs; Parkinson; Alzheimer; TREM2; Microglia;
Keywords: RE; refractory epilepsy; NE; non-epileptic; C3; complement 3; IBA1; ionized calcium-binding adapter molecule 1; Trem2; triggering receptor expressed on myeloid cells 2; MerTK; Mer receptor tyrosine kinase; Pros1; Protein S; Map2; microtubule associated pr
Keywords: AD; Alzheimer disease; APOE; apolipoprotein E; APP; amyloid precursor protein; CERAD; Consortium to Establish a Registry for Alzheimer's Disease; CSF; cerebrospinal fluid; DIAD; dominantly inherited Alzheimer disease; FDA; Food and Drug Administration; FD
Keywords: TREM2; triggering receptor expressed on myeloid cells-2; DC; dendritic cell; DAP12; DNAX-activation protein 12; sTREM2; soluble TREM2; AD; Alzheimer's disease; NHD; Nasu-Hakola disease; LOAD; late-onset AD; MS; multiple sclerosis; Aβ; amyloid beta; CNS
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADCC; antibody dependent cell-mediated cytotoxicity; ALS; amyotrophic lateral sclerosis; APCs; antigen presenting cells; APOE; apolipoprotein E; APP; amyloid precursor protein; APP/PS1; amyloid precursor prote
Keywords: PCA; Posterior Alzheimer's disease; Dementia; APOE; TREM2; PSEN2; NeuroX;
Keywords: Alzheimer's disease; Polygenic risk score; APOE; TREM2; Hippocampus; Amygdala;
Keywords: TREM2; TREML2; Proliferation; Microglia; Inflammation;
Keywords: Microglia; IL-34; CSF-1; CSF-1R; TREM2; Alzheimer's; Neurodegeneration; Glioblastoma
Keywords: TREM2; Aging; Neuroinflammation; Alzheimer's disease; Cognitive deficiency; SAMP8; SAMR1;
Keywords: TREM2; Alzheimer's disease; FTLD; neurodegeneration;
Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement
Keywords: Frontotemporal dementia; TREM2; Genetics; Exome sequencing;
The Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor suppressor protein
Keywords: TREM2; p53; Alzheimer's disease; Actinomycin D; Nutlin-3a;
High TREM2 expression correlates with poor prognosis in gastric cancer
Keywords: TREM2; Protein expression; mRNA expression; Gastric cancer; Prognosis;
Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain
Keywords: TREM2; Alzheimer's disease; Weighted gene coexpression network analysis; RNA-Seq; Knockout mouse model; Endothelial cells;
The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention
Keywords: TREM2; PLD3; Family history; Alzheimer's disease; Memory; Cognition; Longitudinal;
Inflammatory markers of CHMP2B-mediated frontotemporal dementia
Keywords: Autosomal dominantly inherited frontotemporal dementia; Chromosome 3-linked frontotemporal dementia (FTD-3); CHMP2B; Inflammation; TREM2; ACE; Addenbrooke's Cognitive Examination; CSF; Cerebrospinal Fluid; FTD; Frontotemporal Dementia; FTD-3; Chromosome
Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging
Keywords: Alzheimer's disease; Axonal dystrophy; Microglia barrier; Neuroprotection; Optical imaging; TREM2;
Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice
Keywords: Chemotherapeutic neuropathy; Cisplatin; Microglial activation; TREM2; DAP12;
Research articleADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
Keywords: TREM2; Triggering receptor expressed on myeloid cells; AA; amino acids; DAP12; DNAX activating protein 12; ADAM1; a disintegrin and metalloproteinase domain containing protein; TACE; TNFα converting enzyme; Shedding; Alzheimers disease; Macrophages; Neur
Featured ArticleAlzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation
Keywords: Alzheimer's disease; Microglia; TREM2; Monocyte; HDL; LDL; Lipoprotein;
The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
Keywords: Astrogliosis; Microgliosis; TREM2; Glial biomarkers; Inflammation;
Featured ArticleA candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression
Keywords: Alzheimer's disease; eQTL; TREM2; TREML1; Regulatory variant;
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury
Keywords: Apolipoprotein E; Traumatic brain injury; Trem2; Tyrobp; Myelination; Immune response; Fyn; Innate immune response;
TREM2, Microglia, and Neurodegenerative Diseases
Keywords: TREM2; Alzheimer's disease; microglia; APOE; clusterin; APOJ; lipoproteins; neurodegenerative disease; Nasu-Hakola disease; PLOSL; frontotemporal dementia; multiple sclerosis;
Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls
Keywords: SORL1; ABCA7; TREM2; Alzheimer's disease;
N-glycan and Alzheimer's disease
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme-1; DAP12; DNAX-activating protein of 12 kD; GnT-III; N-acetylglucosaminyltransferase-III; NFT; neurofibrillary tangle; PS
Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease
Keywords: Alzheimer's disease; Mild cognitive impairment; TREM2; Microglia; Tau; Amyloid; Immunohistochemistry; Western-blot;
Genetic analysis of TREM2 variants in Chinese Han patients with sporadic Parkinson's disease
Keywords: PD; Parkinson's disease; AD; Alzheimer's disease; TREM2; the triggering receptor expressed on myeloid cells 2 gene; VPS35; the vacuolar protein sorting 35 gene; EIF4G1; the eukaryotic translation initiation factor 4-gamma 1 gene; S100B; the S100 calci
Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain
Keywords: TREM2; Alzheimer's disease; Braak stage; DNA methylation; Epigenetics; AD; Brain;
TYROBP genetic variants in early-onset Alzheimer's disease
Keywords: Alzheimer's disease; TYROBP; TREM2; Exome sequencing; Burden test;
TREMs in Alzheimer's disease: Genetic and clinical investigations
Keywords: AD; Alzheimer's disease; TREM; Triggering receptor expressed on myeloid cells; TREML; TREM like transcript; NHD; Nasu-Hakola disease; NFTs; neurofibrillary tangles; p-tau; hyperphosphorylated tau; GWAS; genome-wide association studies; sTREM2; soluble f
MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease
Keywords: Alzheimer's disease; Monocytes; Macrophages; Chemotaxis; Phagocytosis; CCR2; TREM2; miRNAs
Featured ArticleCerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease
Keywords: Alzheimer's disease; TREM2; Neuroinflammation; Cerebrospinal fluid; Biomarkers;
Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set
Keywords: TREM2; TREML2; MS4A6A; Targeted sequencing; Alzheimer's disease; Mutation;
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice
Keywords: TREM2; Alzheimer's disease; Tau pathology; Microglia; M2 phenotype; Tau kinase; Neuroinflammation;
TREM2 R47H variant and risk of essential tremor: A cross-sectional international multicenter study
Keywords: TREM2; Essential tremor; p.R47H; Risk; Genetics;
TREM2 analysis and increased risk of Alzheimer's disease
Keywords: TREM2; Alzheimer's disease; Risk factor;
More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk
Keywords: TREM2; Rare variants; LOAD;
RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment
Keywords: Alzheimer's disease; APP/PS1 transgenic mice; mRNA-seq; ChIP; RXR; Bexarotene; Trem2; Tyrobp; Aβ phagocytosis;
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid
Keywords: Aβ; β-amyloid; AD; Alzheimer's Disease; AICD; APP Intracellular Domain; APP; Amyloid Precursor Protein; ARG1; Arginase 1; CHF5074; 1-(3â²,4â²-dichloro-2-fluoro[1,1â²-biphenyl]-4-yl)-cyclopropanecarboxylic acid; FIZZ1; Found in Inflammatory Zone; GS
Featured ArticleThe role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
Keywords: Neurodegenerative disease; Alzheimer disease; Frontotemporal lobar degeneration; Amyotrophic lateral sclerosis; Parkinson disease; TREM2; R47H; rs75932628; Rare variant; Genetic association; GWAS; Imputation; Meta-analysis;
Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice
Keywords: TREM2; Tau pathology; Alzheimer's disease; Frontotemporal dementia; Microglia; Neurodegeneration; Spatial cognitive deficits;
Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia
Keywords: Alzheimer's disease; Frontotemporal dementia; TREM2; Genetic association; p.R47H; Rare variant;
Part of the Special Issue: Alzheimer's Disease - Amyloid, Tau and BeyondTREM2 and the neuroimmunology of Alzheimer's disease
Keywords: Microglia; Alzheimer's disease; TREM2; NeuroImmunology;