Keywords: Biphalin; Opioid receptors; MOR/DOR/KOR agonist; Synergistic analgesic effect; Cyclic peptides; Acm; acetamidomethyl; ACN; acetonitrile; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BOP; (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro
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Keywords: SI; supporting information; NBD-Cl; 4-chloro-7-nitrobenzofurazan; NBD-OH; 4-hydroxy-7-nitrobenzofurazan; DIC; N,Nâ²-diisopropylcarbodiimide; DMAP; 4-dimethylaminopyridine; DIEA; N,N-diisopropylethylamine; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,3-tr
Keywords: AP; alkaline phosphatase; anti-huIgG-AP; anti-human IgG alkaline phosphatase labelled; CV; cyclic voltammetry; DMF; dimethylformamide; ELISA; enzyme linked immunoassay; F-moc; 9-fluorenylmethoxy carbonyl; GA; glutaraldehyde; HQ; hydroquinone; HQDP; hydroq
Keywords: AMPs; antimicrobial peptides; TOAC; 2,2,6,6-tetramethyl-piperidine-1-oxyl-4-amino-4-carboxylic acid; HPLC; high performance liquid chromatography; HBTU; O-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluoro-phosphate; TFA; trifluoroacetic acid; TIS; tr
Keywords: EPR; enhanced permeability and retention effect; DTPA; 2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid; TFA; trifluoroacetic acid; Fmoc; 9-fluorenylmethoxycarbonyl; DMF; N,N-dimethylformamide; DCM; dichloromethane; OPfp; pentafluorophenyl ester;
Keywords: BBB; blood brain barrier; BK; bradykinin; Boc; t-butyloxycarbonyl; BR; bradykinin receptor; CNS; central nervous system; DALKD; [des-Arg10, Leu9]-kallidin; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; Dyn A; dynorphin A; Fmoc; fluorenylmethyl
Keywords: RNCGDQLZIATDOU-ZDRBWGSPSA-N; ICYPJNZJUFGALC-PDTBJYIYSA-N; PDRMAVOIWIVXKH-SFUSBHMVSA-N; ISADXJRTBSLWPX-ZDRBWGSPSA-N; NLBLLPROASDPSC-QWWZWVQMSA-N; XKMIKZDBUOHHDK-ZDRBWGSPSA-N; BTURADNXKHTWGA-IJOLSIAMSA-N; UEKHRDLXBMZMPD-ZYIYBEKCSA-N; UQCLCXDOXVZEOA-JARUQAPT
Keywords: CD; circular dichroism; CPE; cytopathic effect; DMF; dimethylformamide; FBS; fetal bovine serum; Fmoc; 9-fluorenylmethoxycarbonyl; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluorophosphate; HOBt; N-hydroxybenzotriazole; HPLC; high perfor
Keywords: Cyclic peptides; Microwave assisted synthesis; Lactam-bridge cyclic peptides; SHU9119; MTII; MWA-SPPS; microwave-assisted solid phase peptide synthesis; MBHA; methylbenzhydryl; MCR; melanocortin receptors; NDP; [Nle4, DPhe7]-αMSH; MTII; melanotan-II; RP-
Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A
Keywords: Adda; (2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid; Amba; (2S,3S)-3-amino-2-methylbutanoic acid; Boc; tert-butoxycarbonyl; BOP; benzotriazol-1-yloxy-tris-dimethylaminophosphoniumhexafluoro phosphate; Cbz; carboxybenzyl; D
Branched pentapeptides as potent inhibitors of the vascular endothelial growth factor 165 binding to Neuropilin-1: Design, synthesis and biological activity
Keywords: Neuropilin-1; VEGF165; Neuropilin/VEGF165 binding inhibition; Structure-activity relationship; Peptide biostability; ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt; Ahp; 7-aminoheptanoic acid; Aun; 11-aminoundecanoic acid;
Evaluation of a novel GRPR antagonist for prostate cancer PET imaging: [64Cu]-DOTHA2-PEG-RM26
Keywords: BBN; bombesin; BFCs; bifunctional chelates; BSA; bovine serum albumin; CB-TE2A; 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane; CH3CN; acetonitrile; C-NE3TA; 4-carboxymethyl-7-[2-(carboxymethyl-amino)-3-(4-nitro-phenyl)-propyl]-[1,4,7]t
Insights into amyloid-like aggregation of H2 region of the C-terminal domain of nucleophosmin
Keywords: TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-Hexafluorophosphate(1-),3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc; Fluorenylmethoxycarbo
Effect of TLR ligands co-encapsulated with multiepitopic antigen in nanoliposomes targeted to human DCs via Fc receptor for cancer vaccines
Keywords: AAA; amino acid analysis; C18; octadecylsilica; DIEA; N,N-diisopropyl-ethylamine; DIPCDI; N,N'-Diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide Fmoc, 9-fluorenylmethoxycarbonyl; HOAt; 1-hydroxy-7-azabenzotriazole (3-hydroxy-
Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli
Keywords: AFM; Atomic Force Microscopy; AMPs; Antimicrobial Peptides; BMDM; Bone-Marrow Derived Macrophages; CC50; 50% cytotoxicity concentrations; CFU; Colony Forming Units; CD; Circular Dichroism; DMEM; Dulbecco's Modified Eagle's Medium; DMPC; 1,2-Dimyristoyl-sn
Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization
Keywords: DIPEA; N,N-diisopropylethylamine; EDCI; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide; DMF; dimethylformamide; EDT; ethanedithiol; HOBt; 1-hydroxybenzotriazole; TFA; trifluoroacetic acid; TIS; triisopropylsilane; EGF; epidermal growth factor; TGF; transfo
Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus
Keywords: RP-HPLC; reversed phase-high performance liquid chromatography; LC; liquid chromatography; MS; mass spectrometry; ACN; acetonitrile; TFA; trifluoroacetic acid; MALDI; matrix-assisted laser desorption/ionization; TOF; time-of-flight; FA; ferulic acid; DTT;
Definition of an 18-mer Synthetic Peptide Derived from the GB virus C E1 Protein as a New HIV-1 Entry Inhibitor
Keywords: Acm; acetamidomethyl; ACN; acetonitrile; Dbz; diaminobenzoyl; DHB; 2,5-dihydroxybenzoic acid; DIPEA; diisopropylethylamine; FP; fusion peptide; GBV-C; GB virus C; HAART; highly active antiretroviral therapy; HATU; 2-(1H-7-azabenzotriazole-1-yl)-1,1,3,3-te
Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors
Keywords: BK; bradykinin; BR; bradykinin receptor; CNS; central nervous system; DALKD; [des-Arg10,Leu9]-kallidin; DIPEA; diisopropylethylamine; DMF; N,N-dimethylformamide; Dyn A; dynorphin A; HR MS; high resolution mass spectroscopy; Fmoc; 9-fluorenylmethoxycarbony
Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment
Keywords: AFM; Atomic force microscopy; CD; circular dichroism; CC; Critical concentration of fibrillation; CuAAC; Cu(I)-catalyzed alkyne-azide cycloaddition; αCD; α-cyclodextrin; N3P3; cyclotriphosphazene; DIC; Diisopropylcarbodiimide; DIPEA; N,N-diisopropylet
Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins
Keywords: Blood-brain barrier (BBB) transport (influx/efflux); Antinociceptive activity; Linear/cyclic enkephalin analogs; In vivo mouse models; AUC; area under the curve; Alloc; allyloxycarbonyl; BBB; blood-brain barrier; Boc; tertButyloxycarbonyl; BSA; bovine
Microwave-assisted guanidinylation in solid phase peptide synthesis: comparison of various reagents
Keywords: Boc; tert-butyloxycarbonyl; Dab; 2,4-diaminobutyric acid; Dap; 2,3-diaminopropionic acid; Dap(g); 3-guanidino-2-aminopropionic acid; DIC; 1,3-diisopropylcarbodiimide; DIEA; diisopropylethylamine; hArg(g); 2,6-diguanidinohexanoic acid; MW; microwave; TBTU;
G-quadruplex DNA recognition by nucleophosmin: New insights from protein dissection
Keywords: TIS; Triisopropylsilane; TFA; Trifluoroacetic acid; DMF; Dimethylformamide; DCM; Dichloromethane; HBTU; 1-H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-hexafluorophosphate(1-), 3 oxide; HOBt; N-hydroxybenzotriazole; DIEA; Di-isopropylethylamine; Fmoc
The interactions of glycated decapeptide, the Amadori product, with copper(II) ions - A possible effect on the oxidative stress induced aggregation?
Keywords: Boc2O; di-tert-butyl dicarbonate; DMF; N,N-dimethylformamide; Fru; aminofructose moiety; TBTU; O-(benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyluronium tetrafluoroborate; TFA; trifluoroacetic acid; TIS; triisopropylsilane; Coordination chemistry; Copper(II)
Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena
Keywords: ACF; animal-component free; BSA; bovine serum albumin; CaCl2; calcium chloride; CD; circular dichroism spectroscopy; CHO; Chinese hamster ovary; CNS; central nervous system; CO2; carbon dioxide; CsF; cesium fluoride; CsOH; cesium hydroxide; DIC; diisoprop
Radiochemical and radiobiological assessment of a pyridyl-S-cysteine functionalized bombesin derivative labeled with the 99mTc(CO)3+ core
Keywords: Boc; t-butyloxycarbonyl; BSA; bovine serum albumin; Cys; cysteine; DIEA; N,N-diisopropylethylamine; DIC; diisopropylcarbamide; DMEM; Dulbecco's modified Eagle medium; DMF; dimethylformamide; EDTA; ethylenediaminetetraacetic acid; ESI-MS; electrospray io
Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus
Keywords: Conotoxins; N-terminal modification; Milked venom; Post-translational modification; α-Conotoxin; Mass spectrometry; API; Atmospheric pressure ionization; Arg(Pbf); N-alpha-9-fluorenylmethoxycarbonyl-N-g-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-l
Linear and cyclic glycopeptide as HIV protease inhibitors
Keywords: HIV-1 protease; Linear and cyclic glycopeptides; Solid and solution peptide synthesis; Molecular docking; AIDS; acquired immunodeficiency syndrome; CTC; 2-chlorotrityl chloride; DCM; dichloromethane; DIPEA; N,N-diisopropyl ethylamine; DMF; N,N-dimethylfor
A 'conovenomic' analysis of the milked venom from the mollusk-hunting cone snail Conus textile-The pharmacological importance of post-translational modifications
Keywords: αα; amino acid; CH3CN; acetonitrile; Acm; acetamidomethyl; API; atmospheric pressure ionization; DHB; dihydroxybenzoic acid; cDNA; complimentary DNA; CHCA; α-Cyano-4-hydroxycinnamic acid; CID; collision induced dissociation; DCM; dichloromethane; DIEA;
Handling a tricycle: Orthogonal versus random oxidation of the tricyclic inhibitor cystine knotted peptide gurmarin
Keywords: 4-PDS; 4,4-dithiodipyridine; Acm; acetamidomethyl; DIPEA; diisopropylethylamine; DMSO; dimethylsulfoxide; EDT; ethanedithiol; ICK; inhibitor cystine knot; NMP; N-methylpyrrolidone; Pyr; pyroglutamic acid; StBu; tert-Butylthio; TFA; trifluoroacetic acid; T
Synthesis and comparative assessment of a labeled RGD peptide bearing two different 99mTc-tricarbonyl chelators for potential use as targeted radiopharmaceutical
Keywords: Arg/R; arginine; Asp/D; aspartic acid; Boc; t-butyloxycarbonyl; BSA; bovine serum albumin; CPA; 3-l-cysteine propionic acid; Cys; cysteine; d-Phe/f; d-phenylalanine; DIEA; N,N-diisopropylethylamine; DIPC; diisopropylcarbamide; DMEM; Dulbecco's modified
Cellular uptake and biophysical properties of galactose and/or tryptophan containing cell-penetrating peptides
Keywords: ATR Spectroscopy; Attenuated Total Reflection Spectroscopy; CPP; cell-penetrating peptide; CHO; Chinese hamster ovary; DIPEA; diisopropylethylamine; DMF; dimethylformamide; DMPC; dimyristoylphosphatidylcholine; DMPG; dimyristoylphosphatidylglycine; DSC; d
Fast and efficient characterization of an anti-gliadin monoclonal antibody epitope related to celiac disease using resin-bound peptides
Keywords: AcOH; acetic acid; Anti-gliadin mAb; anti-gliadin monoclonal antibody; AP; alkaline phosphatase; BSA; bovine serum albumin; CD; celiac disease; DCM; dichloromethane; DIC; N,N'-diisopropylcarbodiimide; DMAP; 4-dimethylaminopyridine; ELISA; enzyme-linked im
Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule: The HIV-1 CD4:gp120 paradigm
Keywords: AcOH; acetic acid; Alloc; allyloxycarbonyl; Boc; t-butoxycarbonyl; BTC; bis(trichloromethyl)carbonate; DBU; 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM; methylene chloride; DIC; N,Nâ²-diisopropylcarbodiimide; DIPEA; diisopropylethylamine; DMAP; dimethylamino
An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted 'click-chemistry'
Keywords: Porphyrins; Angiogenesis; Click-chemistry; Microwaves; PDT; Cyclic peptide; Abs301; absorbance at 301Â nm; AcOH; acetic acid; All; allyl; Boc; tert-butoxycarbonyl; Da; dalton; DIEA; N,N-diisopropylethylamine; DMAc; N,N-dimethylacetamide; DMF; N,N-dimethyl
Controlling the outcome of overacylation of N-protected aminooxyacetic acid during the synthesis of an aminooxy-peptide for chemical ligation
Keywords: Aloc; allyloxycarbonyl; Aoa; aminooxyacetic acid; DCC; N,Nâ²-dicyclohexylcarbodiimide; DIEA; N,N-diisopropylethylamine; DMAP; 4-dimethylaminopyridine; Fmoc; 9-fluorenylmethoxycarbonyl; HATU; 2-(1H-7-azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexaf
Introduction of the Aib-Pro unit into peptides by means of the 'azirine/oxazolone method' on solid phase
Keywords: α-Aminoisobutyric acid; Azirine/oxazolone method; Peptaibols; Peptide synthesis; Photocleavable linker; Aib; α-aminoisobutyric acid; DIPEA; N,N-diisopropylethylamine; HOBt; 1-hydroxybenzotriazole; PyBOP; (1H-benzotriazol-1-yloxy)tripyrrolidinophosphoniu
Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions
Keywords: Peptide nucleic acid; Conjugation; Solid-phase synthesis; Boc; t-butyloxycarbonyl; Bhoc; benzhydryloxycarbonyl; DTT; dithiothreitol; Fmoc; 9-fluorenylmethyloxycarbonyl; PMB; para-methoxybenzyl; EDC; N-(3-dimethylaminopropyl)-Nâ²-ethylcarbodiimide hydroch
Synthesis, structure, and biological aspects of cyclopeptides related to marine phakellistatins 7-9
Keywords: Cyclopeptides; Solid phase synthesis; Marine natural products; Cytotoxic; AcOH; acetic acid; AA; amino acid; DCM; dichloromethane; DIEA; diisopropylethylamine; DKP; diketopiperazine; DMEM; Dulbecco's modified Eagle's medium; DMF; N,N-dimethylformamide; ES
Synthesis and preliminary physical applications of a rhodamin-biotin phosphatidylethanolamine, an easy attainable lipid double probe
Keywords: Boc; tertio-butyloxycarbonyl; DBU; 1,8-diazabicyclo[5,4,0]undec-7-ene; DHB; 2,5-dihydroxybenzoic acid; DIEA; diisopropyl ethyl amine; DMAP; 4-N,N-dimethylaminopyridine; DMF; N,N-dimethylformamide; DSPE; distearyl-phosphatidylethanolamine; Fmoc; 9-fluoreny