Keywords: Triptolide; Nanoparticle; Hepatocellular carcinoma; Network pharmacology; Toxicity;
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: ABC; ATP-binding cassette; AKT; V-Akt murine thymoma viral oncogene homolog; ALDH1; aldehyde dehydrogenase 1; AR; androgen receptor; Bad; Bcl-2-associated death promoter; Bak; Bcl-2 homologous antagonist killer; Bax; Bcl-2-associated X protein; Bcl-2; B-c
Keywords: Selenium-enriched Cordyceps militaris; Triptolide; Hepatotoxicity; Antioxidative; Nrf2 pathway; Anti-apoptosis;
Keywords: TP; triptolide; LPS; lipopolysaccharides; MoMF; monocyte-derived macrophage; MCP-1; monocyte chemoattractant protein-1; ROS; reactive oxygen species; ALT; alanine transaminase; AST; aspartate transaminase; HPRT1; hypoxanthine phosphoribosyltransferase 1;
Keywords: Triptolide; Mitochondria damage; SIRT1; Fatty acid metabolism; Testicular toxicity;
Keywords: Depression; Chronic pain; Comorbidity; Triptolide; Fluoxetine; Hippocampus; Neuroinflammation;
Keywords: Triptolide; GSK-3β; Cardioprotection; Mitochondrial permeability transition pore; Apoptosis; SB 216763; Cyp-F; cyclophilin F; DCF-DA; 2â², 7â²-dichlorofluorescein-diacetate; GSK-3β; glycogen synthase kinase 3β; mPTP; mitochondrial permeability transi
Keywords: Glycerol trioleate (PubChem CID: 5497163); Astragaloside (PubChem CID: 45006101); β-sitosterol (PubChem CID: 222284); Triptonoterpenol (PubChem CID: 159330); Stachydrine hydrochloride (PubChem CID: 44150282); Ursolic acid (PubChem CID: 64945); Triptolide
Keywords: Triptolide; Fragment peptide; Renal targeting; Conjugate; Human serum albumin;
Keywords: DILI; drug-induced liver injury; IL-17; interleukin-17; Th17 cells; T helper 17 cells; TP; triptolide; TWHF; Tripterygium wilfordii Hook F; Treg; regulatory T cells; T-bet; T-box expressed in T cells; GATA-3; GATA-binding domain-3; FoxP3; Forkhead box P3;
Triptolide derivatives as potential multifunctional anti-Alzheimer agents: Synthesis and structure-activity relationship studies
Keywords: Triptolide; Memantine; Neuroprotection; Neuroinflammation; Aβ;
The protective effects of triptolide on age-related bone loss in old male rats
Keywords: Triptolide; Osteoporosis; Osteoclast; Male rats;
Triptolide inhibits pituitary adenoma cell viability, migration and invasion via ADAM12/EGFR signaling pathway
Keywords: Triptolide; Pituitary adenomas; ADAM12; EGFR;
Overexpression and RNAi-mediated downregulation of TwIDI regulates triptolide and celastrol accumulation in Tripterygium wilfordii
Keywords: Tw; Tripterygium wilfordii; OE; overexpression; RNAi or Ri; RNA interference; IDI; isopentenyl diphosphate isomerase; CDS; coding sequence; TwIDI; Overexpression; RNAi; Triptolide; Celastrol; Gene gun;
Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis
Keywords: RA; rheumatoid arthritis; TP; triptolide; AA; adjuvant-induced arthritis; MPO; myeloperoxidase; NE; neutrophil elastase; TNF-α; tumor necrosis factor α; IL-6; interleukin 6; CCL-5; C-C motif chemokine ligand 5; GM-CSF; granulocyte-macrophage colony-stim
Low, but not high, dose triptolide controls neuroinflammation and improves behavioral deficits in toxic model of multiple sclerosis by dampening of NF-κB activation and acceleration of intrinsic myelin repair
Keywords: Apoptosis; Cuprizone; Demyelination; Multiple sclerosis; Neuroinflammation; Triptolide;
Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes
Keywords: TP; Triptolide; TWHF; Tripterygium wilfordii Hook f; MOMP; mitochondrial outer membrane permeanilization; PFTα; Pifithrin-α; BIP V5; Bax inhibitor peptide V5; DOX; Doxorubicin; TUNEL Assay; Terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick
Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol
Keywords: Triptolide (PubChem CID:107985); Catapol (PubChem CID:24721265); Panax notoginseng saponins (PubChem CID:441934); Triptolide; Catapol; Panax notoginseng saponins; Nrf1; Hepatotoxicity; Mitochondria;
Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition
Keywords: Idiopathic pulmonary fibrosis; EMT; TGFB1; Triptolide; Paraquat;
Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity
Keywords: Nrf2; Chemoresistance; Triptolide; NSCLC;
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease
Keywords: mGlu; Metabotropic glutamate receptor; PD; Parkinson's disease; T10; Triptolide; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF; tumor necrosis factor; IL; interleukin; SN; substantia nigra; COX; cyclooxygenase; JN
Inhibitory effect of Triperygium wilfordii polyglucoside on dipeptidyl peptidase I in vivo and in vitro
Keywords: DPPI activity; Triperygium Wilfordii Polyglucoside; Triptolide; CIA rat model;
Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperplasia in Sprague Dawley rats
Keywords: Triptolide; Benign prostatic hyperplasia; Androgen;
Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression
Keywords: Myocardial remodeling; Inflammation; NLRP3; Hypertension; Triptolide; Triptolide(PubChem CID: 107985);
Molecular cloning and functional identification of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Tripterygium wilfordii
Keywords: Tripterygium wilfordii; Triptolide; 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase; Complementation; Gene expression;
Atractylodes lancea rhizome water extract reduces triptolide-induced toxicity and enhances anti-inflammatory effects
Keywords: Triptolide; Atractylodes lancea; Licorice; CYP3A; Anti-inflammation effects;
UPLC/ESI-QTOF-MS-based metabolomics survey on the toxicity of triptolide and detoxication of licorice
Keywords: Metabolomics; Triptolide; Licorice; Toxicity; Detoxication; UPLC/ESI-QTOF-MS;
AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells
Keywords: Osteosarcoma; AMD3100; Triptolide; Erk1/2; Akt; STAT3;
TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells
Keywords: Truncated retinoic X receptor-alpha; AKT; Cancer; Triptolide; Derivatives;
Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway
Keywords: Quercetin; Triptolide; Th17/Treg balance; Tim-3; TLR4;
Toxicity of triptolide and the molecular mechanisms involved
Keywords: Triptolide; Toxicokinetics; Toxicity; Molecular mechanisms; Protection;
Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity protein 1 in primary effusion lymphoma cells
Keywords: Triptolide; hTERT; Sp1; PEL cells;
Triptolide attenuated injury via inhibiting oxidative stress in Amyloid-Beta25-35-treated differentiated PC12 cells
Keywords: Alzheimer's disease (AD); Triptolide; Differentiated PC12 cells; Reactive oxygen species (ROS); Amyloid-Beta25-35 (Aβ25-35);
Partial synthesis of 14-deoxy-14-aminotriptolide
Keywords: Triptolide; Reductive amination; Aminotriptolide; Cytotoxicity;
Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway
Keywords: Triptolide; Rheumatoid arthritis; Fibroblast-like synoviocyte; Aggressiveness; c-Jun N-terminal kinase;
Activation of SIRT3 attenuates triptolide-induced toxicity through closing mitochondrial permeability transition pore in cardiomyocytes
Keywords: Triptolide; SIRT3; Mitochondrial permeability transition pore; Cardioprotection;
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC
Minnelide, a novel drug for pancreatic and liver cancer
Keywords: Triptolide; Minnelide; Pancreatic cancer; Hepatocellular carcinoma; Animal models; Translational study;
Triptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1
Keywords: LMP1; Triptolide; B lymphocytes; ED-L1; EBV;
Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-қB activation and titanium particle-induced osteolysis in a mouse model
Keywords: Triptolide; Osteoclastogenesis; RANKL; NF-κB; Osteolysis; Titanium particle
Pharmacokinetic and pharmacodynamic study of triptolide-loaded liposome hydrogel patch under microneedles on rats with collagen-induced arthritis
Keywords: Pharmacokinetics; Pharmacodynamics; Triptolide; Micro-electro-mechanical system; Microneedles; Collagen-induced arthritis
Simultaneous LC−MS/MS determination of five tripterygium pyridine alkaloids in dog plasma and its application to their pharmacokinetic study after oral administration of tripterygium glycosides tablets
Keywords: Triptolide; Wilforine; Wilforgine; Wilfording; Wilfortrine; LC–MS/MS
Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells
Keywords: Triptolide; Oxidative stress; Nrf2; Quercetin; Apoptosis; Leydig cellsTP, Triptolide; Que, Quercetin; ΔΨm, mitochondrial membrane potential; GPx, glutathione peroxidase; SOD, superoxide dismutase; ROS, reactive oxygen species; Nrf2, NF-E2-related factor;
TRPP2 modulates ryanodine- and inositol-1,4,5-trisphosphate receptors-dependent Ca2+ signals in opposite ways in cerebral arteries
Keywords: TRPP2; Ryanodine receptor; Aging; Triptolide; Calcium signaling;
A renal-targeted triptolide aminoglycoside (TPAG) conjugate for lowering systemic toxicities of triptolide
Keywords: Glycosidic bond; Triptolide; 2-Glucosamine; Renal-targeting; Low toxicity; Triptolide
Autophagy plays an important role in triptolide-induced apoptosis in cardiomyocytes
Keywords: Triptolide; Autophagy; Apoptosis; Mitochondrion; Cardioprotective; Rapamycin
Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study
Keywords: Triptolide; GC-MS; Metabolomics; Testicular toxicity; Spermatozoa; PPARs;
Semisynthesis of triptolide analogues: Effect of B-ring substituents on cytotoxic activities
Keywords: Diterpenoid; Triptolide; Structure-cytotoxic activity relationships; Cytotoxic; Synthesis;
Triptolide improves nerve regeneration and functional recovery following crush injury to rat sciatic nerve
Keywords: Triptolide; Peripheral nerve injury; Nerve regeneration; Pro-inflammatory cytokines
T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease
Keywords: Crohn's disease; Tripterygium wilfordii Hook F; Triptolide; Regulatory t cells;