Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1
Keywords: TRPA1; Behavior; Endothelin-1; Pruritus;
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Allyl isothiocyanates and cinnamaldehyde potentiate miniature excitatory postsynaptic inputs in the supraoptic nucleus in rats
Keywords: TRPA1; EPSC; IPSC; Slice patch clamp; Supraoptic nucleus
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation
Keywords: TRPA1; Blockade; Pain; Noxious cold; Temperature sensation; Temperature regulation;
Sensing pulmonary oxidative stress by lung vagal afferents
Keywords: Oxidative stress; Airways; Lung; Bronchopulmonary; Nerve; Neuron; Afferent; C-fiber; Nociceptor; Nociception; Transient receptor potential; TRPA1; TRPV1; P2X; Capsaicin; Mustard oil; Allyl iosthiocyanate; Cinnamaldehyde; Reactive oxygen species; ROS; Elec
Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and col
Keywords: TRPV1; TRPA1; mechanosensitive K2P channel; lumbar splanchnic nerve; pelvic nerveDRG, dorsal root ganglia; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; K2P, two pore-domain K+; LS, lumbosacral; LSN, lumbar splanchnic nerve; PN, pelvic nerve; RT-PCR, r
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation
Keywords: Oxaliplatin; TRPA1; Cold and mechanical hyperalgesia; Primary sensory neurons; Oxidative stress;
Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors
Keywords: ATP; benzoylbenzoyl ATP; brilliant blue G; minocycline; mustard oil; periodated oxidized ATP; ANOVA; analysis of variances; BBG; brilliant blue G; BzATP; 2â²3â²-o-(4-benzoylbenzoyl) adenosine 5â²-triphosphate (ATP); DPCPX; 8-cyclopentyl-1,3-dipropylxan
Irritant-Induced Airway Disorders
Keywords: Reactive airways dysfunction syndrome; RADS; Irritancy; Ion channels; TRPV1; TRPA1;
Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels
Keywords: Non-neuronal; Nav1.1-Nav1.9; Dental pulp; Gingiva; Periodontium; TRPA1; Nestin;
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system
Keywords: Chemesthesis; Chemosensation; Gastrointestinal cancer; Gastrointestinal motility; Hypersensitivity; Hyperalgesia; Inflammation; Inflammatory bowel disease; Mechanosensation; Pain; Taste; Transducers; TRPA1; TRPC4; TRPC6; TRPM5; TRPM6; TRPV1; TRPV4; TRPV6;
Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats
Keywords: TRPA1; Cinnamaldehyde; Nociception; Heat hyperalgesia; Cold hyperalgesia; Mechanical allodynia
(−)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels
Keywords: Transient receptor potential channels; TRPA1; TRPV1; TRPM8; (−)-Menthylamine derivatives
Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor
Keywords: TRPA1; TRP; Antagonist; Agonist; Transient Receptor Potential; Ankyrin-repeat Transient Receptor Potential 1; Oxime; AP18
Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat
Keywords: Substance P; Hemokinin-1; TRPV1; TRPA1; TRPM8; Scratching behavior; Intrathecal administration
The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
Keywords: TRPA1; Persistent inflammation; Cold and mechanical hyperalgesia;
Transient Receptor Potential A1 and Cannabinoid Receptor Activity in Human Normal and Hyperplastic Prostate: Relation to Nerves and Interstitial Cells
Keywords: Prostate; Sensory; Cholinergic; Nerve; c-kit; cGMP; Cell; TRPA1; CB1; CB2
Vagal afferent nerves with the properties of nociceptors
Keywords: Vagus; Nociceptors; Pain; Cough; TRPV1; TRPA1
Neonatal colon insult alters growth factor expression and TRPA1 responses in adult mice
Keywords: Visceral pain; Growth factor; Neuronal plasticity; TRPV1; TRPA1;
Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca2+
Keywords: TRPA1; TRPV1; pain; CAP; capsaicin; [Ca2+]e; extracellular Ca2+; [Ca2+]i; intracellular Ca2+; CHO; Chinese hamster ovary; Co-IP; Co-immunoprecipitation; GFP; green fluorescent protein; IMO; mustard oil current; MO; mustard oil; TG; trigeminal ganglia; TRP
Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli
Keywords: DRG; Nerve injury; Capsaicin; Formalin; Mustard oil; Menthol; TRPV1; TRPA1; TRPM8;
Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands
Keywords: Fatty acid amide hydrolase; FAAH; Transient receptor potential channels; TRPV1; TRPA1; Dual-ligands; Piperazinyl carbamates
TRPA1: A potential target for anti-tussive therapy
Keywords: Cough; Airway sensory nerve; C-fiber; Nociceptor; TRPA1; TRPV1; Irritant; Electrophilic; Reactive; Oxidative stress; COPD; Asthma
Mustard oil enhances spinal neuronal responses to noxious heat but not cooling
Keywords: Spinal cord; Noxious heat; Skin cooling; Rat; Dorsal horn; Nociception; TRPA1; Mustard oil
TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase
Keywords: Lidocaine; Procaine; TRPA1; l-glutamate; Excitatory transmission; Substantia gelatinosa; Spinal dorsal horn; Slice preparation; Patch-clamp
TRPA1 expression in human lingual nerve neuromas in patients with and without symptoms of dysaesthesia
Keywords: TRPA1; Dysaesthesia; Lingual nerve; Nerve injury; Immunohistochemistry
Transient Receptor Potential A1 (TRPA1) Activity in the Human Urethra—Evidence for a Functional Role for TRPA1 in the Outflow Region
Keywords: Cinnamaldehyde; Human; Hydrogen sulfide; Interstitial cell; Relaxation; Sensory nerve; TRPA1; TRPV1; Urethra; Urothelium
Miogadial and miogatrial with α,β-unsaturated 1,4-dialdehyde moieties—Novel and potent TRPA1 agonists
Keywords: TRPA1; Miogadial; Miogatrial; Polygodial; TRPV1; HC-030031
A Randomized Controlled Trial of Antioxidant Supplementation for Pain Relief in Patients With Chronic Pancreatitis
Keywords: BMI; body mass index; CP; chronic pancreatitis; e-SOD; erythrocyte superoxide dismutase; FRAP; ferric reducing ability of plasma; HNE; 4-hydroxy-2-nonenal; RCTs; randomized controlled trials; SPINK1; serine protease inhibitor Kazal type 1; S-SOD; serum su
The Ion Channel TRPA1 Is Required for Normal Mechanosensation and Is Modulated by Algesic Stimuli
Keywords: DRG; dorsal root ganglia; LS; lumbosacral; QRT-PCR; quantitative reverse transcription polymerase chain reaction; TL; thoracolumbar; TRPA1; transient receptor potential channel ankyrin 1; TRPV; transient receptor potential channel vanilloid;
Neuroimaging the genomics of pain processing-a perspective
Keywords: pain; pain modulation; neuroimaging; genes; genetics; BDNF; brain-derived neurotrophic factor; CIP; congenital insensitivity to pain; COMT; catechol-O-methyltransferase; fMRI; functional magnetic resonance imaging; GCH1; GTP cyclohydrolase 1; GDNF; glial
Development, plasticity and modulation of visceral afferents
Keywords: Bladder; Colon; Jugular; Nodose; Neonatal; Pain; Pancreas; P2X; TRPV1; TRPA1; TRPV4; Vagus
Roles of transient receptor potential channels in pain
Keywords: TRPA1; TRPV1; TRPM8; Cold; Mechanotransduction; Nociceptor; Sensory neuron; Cutaneous; Inflammation; Prostaglandin; NGF; Artemin; Bradykinin; Kinase; Scaffold protein
TRPA1 channel activation induces cholecystokinin release via extracellular calcium
Keywords: TRP channel; TRPA1; Cholecystokinin release; Calcium
Cross-desensitization of responses of rat trigeminal subnucleus caudalis neurons to cinnamaldehyde and menthol
Keywords: Menthol; Cinnamaldehyde; TRPM8; TRPA1; Cold; Trigeminal
TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons
Keywords: Human; Nerve; DRG neurons; TRPA1; Pain
Contribution of TRPV1 to the bradykinin-evoked nociceptive behavior and excitation of cutaneous sensory neurons
Keywords: Bradykinin; Inflammation; Pain; TRPV1; Nocifencive behavior; C-fibers; DRG neurons; TRPA1;
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors
Keywords: TRPV1; TRPA1; Nociceptor; Capsaicin; Mustard oil; Trigeminal; Pain
Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury
Keywords: Cold hypersensitivity; Cold allodynia; Cold injury; Menthol; Cinnamaldehyde; Temperature threshold; Axon-reflex-flare; Psychophysics; TRPM8; TRPA1;
Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder
Keywords: Cystometry; Hydrogen sulfide; Micturition; Rat; Sensory neurons; Transient receptor potential ion channels; TRPA1; TRPV1; Urinary bladder; Urothelium
Comparison of icilin- and cold-evoked responses of spinal neurones, and their modulation of mechanical activity, in a model of neuropathic pain
Keywords: Spinal cord; Primary afferent fibre; Cold allodynia; TRPM8; TRPA1;
Pronociceptive response elicited by TRPA1 receptor activation in mice
Keywords: transient potential receptor; allyl isothiocyanate; cinnamaldehyde; capsaicin; mast cells; histamine; AS-ODN; antisense oligodeoxynucleotide; DRG; dorsal root ganglia; ED50; dose of allyl isothiocyanate, cinnamaldehyde or capsaicin producing nociceptive r
Induction of total insensitivity to capsaicin and hypersensitivity to garlic extract in human by decreased expression of TRPV1
Keywords: TRPV1; Capsaicin; Buccal mucosa; TRPA1; Allicin
Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury
Keywords: Transient receptor potential; Temperature; TRPV1; TRPV2; TRPV3; TRPV4; TRPA1; TRPM8; Neuropathic pain; Cold hypersensitivity
Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine
Keywords: Colon; Contraction; Allyl isothiocyanate; Capsaicin; TRPA1; TRPV1
TRP channels and pain
Keywords: Pain; TRPV1; TRPA1; Mechanical hypersensitivity; Nociceptive processing; Inflammation
Plasticity in intact Aδ- and C-fibers contributes to cold hypersensitivity in neuropathic rats
Keywords: peripheral neuropathy; sensitization; TRPA1; TRPM8; neuropathic pain; cold allodynia; ADM; Aδ-mechanical unit; ADMC; Aδ-mechanocold unit; ADMH; Aδ-mechanoheat unit; ADMHC; Aδ-mechanoheat-cold unit; CM; C-mechanoreceptor unit; CMC; C-mechanocold unit;
Alterations in the Brain-Gut Axis Underlying Visceral Chemosensitivity in Nippostrongylus brasiliensis-Infected Mice
Keywords: Cckar (CCKA); Cholecystokinin A receptor; CTB; cholera toxin beta subunit; DRG; dorsal root ganglia; Gabrb3; Gamma-aminobutyric acid receptor subunit beta 3; Glrb; Glycine receptor beta subunit; Htr3a (5-HT3A); 5-hydroxytryptamine (serotonin) receptor 3A;
TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD
Keywords: TRPA1; CYLD; Ubiquitination; Cylindroma; Icilin
Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder
Keywords: Allyl isothiocyanate; Cinnamaldehyde; Tachykinins; Prostaglandin E2; Capsaicin; TRPV1; TRPA1
Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats
Keywords: Neuropathic pain; TRPA1; TRPM8; Dorsal root ganglion; Spared neurons