کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4341186 | 1295826 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plasticity in intact Aδ- and C-fibers contributes to cold hypersensitivity in neuropathic rats
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کلمات کلیدی
SNLADMTRPM8CMHNGFPWTSIFtransient receptor potential A1DRGCMCTRPA1dorsal root ganglion - گانگلیون ریشه پشتیpaw withdrawal threshold - آستانه برداشتن پاcold allodynia - آلدینیا سردtumor necrosis factor-α - تومور نکروز عامل αSensitization - حساسیتNeuropathic pain - درد نوروپاتیکruthenium red - رتنیم قرمزConduction velocity - سرعت هدایتnerve growth factor - فاکتور رشد عصبTNF-α - فاکتور نکروز توموری آلفاsynthetic interstitial fluid - مایع بینابینی مصنوعیperipheral neuropathy - پلینوریتspinal nerve ligation - پیوند عصب ستون فقرات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cold hypersensitivity is a common sensory abnormality accompanying peripheral neuropathies and is difficult to treat. Progress has been made in understanding peripheral mechanisms underlying neuropathic pain but little is known concerning peripheral mechanisms of cold hypersensitivity. The aim of this study was to analyze the contribution of uninjured primary afferents to the cold hypersensitivity that develops in neuropathic rats. Rats with a lumbar 5 (L5) and L6 spinal nerve ligation (SNL, Chung model) but not sham, developed mechanical allodynia, evidenced by decreased paw withdrawal thresholds and increased magnitude of response to von Frey stimulation. Cold hypersensitivity also developed in SNL but not sham rats, evidenced by enhanced nociceptive behaviors induced by placement on a cold plate (6 °C) or application of icilin (a transient receptor potential M8 (TRPM8)/transient receptor potential A1 (TRPA1) receptor agonist) to nerve-injured hind paws. Single fiber recordings demonstrated that the mean conduction velocities of intact L4 cutaneous Aδ- and C-fibers were not different between naive and SNL rats; however, mechanical thresholds of the Aδ- but not the C-fibers were significantly decreased in SNL compared with naive. There was a higher prevalence of C-mechanoheat-cold (CMHC) fibers in SNL compared with naive, but the overall percentage of cold-sensitive C-fibers was not significantly increased compared with naive. This was in contrast to the numerous changes in Aδ-fibers: the percentage of L4 cold sensitive Aδ-, but not C-fibers, was significantly increased, the percentage of L4 icilin-sensitive Aδ-, but not C-fibers, was significantly increased, the icilin-induced activity of L4 Aδ-, but not C-fibers, was significantly increased. Icilin-induced activity was blocked by the TRPA1 antagonist Ruthenium Red. The results indicate plasticity in both Aδ- and C-uninjured fibers, but Aδ fibers appear to provide a major contribution to cold hypersensitivity in neuropathic rats.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 150, Issue 1, 30 November 2007, Pages 182-193
Journal: Neuroscience - Volume 150, Issue 1, 30 November 2007, Pages 182-193
نویسندگان
G. Ji, S. Zhou, M.Y. Kochukov, K.N. Westlund, S.M. Carlton,