دانلود مقالات ISI درباره آستانه برداشتن پا + ترجمه فارسی

استخدام سیناپتی وابسته به فعالیت وابسته به نورولین 1 در شاخ پشتی نخاعی به درد التهابی کمک می کند

Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal Dorsal Horn Contributed to Inflammatory Pain

Keywords: آستانه برداشتن پا; ACSF; artificial cerebrospinal fluid; CaMKII; Ca2+/calmodulin-dependent protein kinase II; CFA; complete Freund's adjuvant; D-APV; D(−)-2-Amino-5-phosphonopentanoic acid; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

هدف قرار دادن فارماکولوژیک ساعتهای پستانداران، یک ضد درد جدید برای درد ناشی از استئوآرتریت است

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain

Keywords: آستانه برداشتن پا; OA; Osteoarthritis; f/f; floxed-floxed, lox P, sandwiching of a DNA sequence; PMM; Partial medial meniscectomy; h; hour; j; Jackson Laboratory; LD; light-dark; DL; dark-light; PWT; paw withdrawal threshold; PTT; paw thermal threshold; DRG; dorsal root gan

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

مدولاسیون نوروپپتیدی نخاعی، ارزیابی عملکردی و ضایعات غضروف در یک مدل موش صحرایی یوتوآستاته استئوآرتریت

Spinal neuropeptide modulation, functional assessment and cartilage lesions in a monosodium iodoacetate rat model of osteoarthritis

Keywords: آستانه برداشتن پا; OA; osteoarthritis; D; day; IA; intra-articular; MIA; monosodium iodoacetate; SP; substance P; CGRP; calcitonin gene related-peptide; BK; bradykinin; STT; somatostatin; (NF)-κB; nuclear factor-kappa B; L; lidocaine; PWT; paw withdrawal threshold; n; numb

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

تحریک موضعی الکتریکی عصبی محیطی، مسیرهای درد مرکزی را مدوله کرده و موجب کاهش هیپرآلژزیس عروقی و سمی در موشهای صحرایی می شود

Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats

Keywords: آستانه برداشتن پا; CeA; central nucleus of the amygdala; CRD; colorectal distension; NTS; nucleus tractus solitarius; PENFS; percutaneous, electrical nerve field stimulator; PWT; paw withdrawal threshold; RVM; rostral ventral medulla; TNBS; trinitrobenzenesulfonic acid; VMR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

تبدیل فاکتور رشد بتا در هسته قرمز اثر ضددردی را تحت شرایط درد فیزیولوژیکی و پاتولوژیک قرار می دهد

Transforming growth factor-beta in the red nucleus plays antinociceptive effect under physiological and pathological pain conditions

Keywords: آستانه برداشتن پا; ANOVA; analysis of variance; CCI; chronic constriction injury; IgG; immunoglobulin G; IL; Interleukin; IR; immunoreactivity; JOR; jaw-opening reflex; MOD; mean optical density; PWT; paw withdrawal threshold; RN; red nucleus; SNI; spared nerve injury; TGF-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

کاهش غلظت اندومورفین-2 نخاعی با الودینای مکانیکی در یک مدل موش سرطان تیبیا

Downregulation of spinal endomorphin-2 correlates with mechanical allodynia in a rat model of tibia cancer

Keywords: آستانه برداشتن پا; β-FNA; β-funaltrexamine; ANOVA; analysis of variance; CIBP; Cancer-induced bone pain; DRG; dorsal root ganglion; EM2; endomorphin-2; EM2-IP; EM2-immunopositive; MOR; μ opioid receptor; PB; phosphate buffer; PBS; phosphate-buffered saline; POD; post-ope

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Norepinephrine-induced downregulation of GLT-1 mRNA in rat astrocytes

Keywords: آستانه برداشتن پا; Astrocyte; Descending inhibitory pathway; Glutamate transporter; Neuropathic pain; Norepinephrine; Spinal cord; ANOVA; analysis of variance; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco's Modified Eagle's Medium; EDTA; ethylenediaminetetraacetic

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

Corticotropin-Releasing Factor in the Brain and Blocking Spinal Descending Signals Induce Hyperalgesia in the Latent Sensitization Model of Chronic Pain

Keywords: آستانه برداشتن پا; ANOVA; analysis of variance; CeA; central amygdala; CFA; complete Freund's adjuvant; CRF; corticotropin-releasing factor; HPA; hypothalamic-pituitary-adrenal; i.c.v.; intracerebroventricular; i.th.; intrathecal; NTX,; naltrexone; NK1R; neurokinin 1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats

Keywords: آستانه برداشتن پا; LBP; Lycium barbarum polysaccharide; DM; diabetes mellitus; DPN; diabetic peripheral neuropathy; LC3-II; microtubule-associated protein 1 light chain 3-II; HDL; high density lipoprotein; SC; Schwarm cell; STZ; streptozotocin; LA; lipoic acid; PWT; paw wit

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K

Keywords: آستانه برداشتن پا; AMPA receptor; α-amino-3-hydroxy-5-methy-4-isoxazole propionate receptor; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; DRG; dorsal root ganglion; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ethe

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2018 سفارش ترجمه

Increased Neuroligin 2 Levels in the Postsynaptic Membrane in Spinal Dorsal Horn may Contribute to Postoperative Pain

Keywords: آستانه برداشتن پا; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; CPS; cumulative pain score; PSD-95; postsynaptic density protein 95; PWT; paw withdrawal threshold; siRNA; small interfering ribonucleic acid; TTBS; Tween/Tris-buffered saline solution; postoperati

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Blockade of vascular endothelial growth factor receptor-1 (Flt-1), reveals a novel analgesic for osteoarthritis-induced joint pain

Keywords: آستانه برداشتن پا; OA; osteoarthritis; PMM; partial medial meniscectomy; h; hour; PWT; paw withdrawal threshold; PTT; paw thermal threshold; DRG; dorsal root ganglion; IT; intrathecal; IA; intraarticular; RT-PCR; Real-time polymerase chain reaction; P; probability; SEM; sta

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Neurotoxic effect of oxaliplatin: Comparison with its oxalate-free analogue cis-[PtII(1R,2R-DACH)(3-acetoxy-1,1-cyclobutanedicarboxylato)] (LLC-1402) in mice

Keywords: آستانه برداشتن پا; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ATF3; activating transcription factor 3; CREB; cyclic AMP response element binding protein; DACH; diaminocyclohexane; DRG; dorsal root ganglia; iNOS; inducible nitric oxide synthase; LLC-1402

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Astaxanthin ameliorates behavioral and biochemical alterations in in-vitro and in-vivo model of neuropathic pain

Keywords: آستانه برداشتن پا; AD; Alzheimer's disease; BBB; blood brain barrier; BSA; bovine serum albumin; CNS; central nervous system; CCI; chronic constriction injury; DMSO; dimethylsulphoxide; DTNB; 5,5′-dithio-bis-[2-nitrobenzoic acid]; FBS; fetal bovine serum; FITC; fluoresc

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats

Keywords: آستانه برداشتن پا; Brain-derived neurotrophic factor; Incisional pain; Long-term potentiation; Neonatal rat; Spinal dorsal horn; ACC; the anterior cingulate cortex; AMPAR; α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptor; ANOVA; analysis of variance; BDNF;

دانلود رایگان متن کامل مقاله ISI 74 صفحه سال انتشار : 2018 سفارش ترجمه

Silencing of FKBP51 alleviates the mechanical pain threshold, inhibits DRG inflammatory factors and pain mediators through the NF-kappaB signaling pathway

Keywords: آستانه برداشتن پا; FKBP51; FK506 binding protein 51; CCI; chronic constriction injury; PWT; paw withdrawal threshold; PWL; paw withdrawal latency; DRG; dorsal root ganglion; FKBP51; Neuro-inflammation; Neuropathic pain; NF-κB signaling;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Biochanin-A attenuates neuropathic pain in diabetic rats

Keywords: آستانه برداشتن پا; Allodynia; Diabetic neuropathy; Hyperalgesia; Isoflavone; Streptozotocin; Hyperglycemia; Paw withdrawal threshold; von Frey filaments;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Downregulations of TRPM8 expression and membrane trafficking in dorsal root ganglion mediate the attenuation of cold hyperalgesia in CCI rats induced by GFRα3 knockdown

Keywords: آستانه برداشتن پا; TRPM8; transient receptor potential melastatin 8; CCI; chronic constriction injury; DRG; dorsal root ganglion; GFRα3; glial cell line-derived neurotrophic factor family receptor alpha3; siRNA; small interfering RNA; TRP; transient receptor potential; dsR

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-hypersensitive effect of intramuscular administration of αO-conotoxin GeXIVA[1,2] and GeXIVA[1,4] in rats of neuropathic pain

Keywords: آستانه برداشتن پا; nAChR; nicotinic acetylcholine receptor; AUC; area under curve; CCI; chronic constriction injury; PWT; paw withdrawal threshold; αO-Conotoxin GeXIVA[1,2]; αO-Conotoxin GeXIVA[1,4]; Neuropathic pain; Mechanical hyperalgesia; Thermal pain;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity

Keywords: آستانه برداشتن پا; CB1 receptor; cannabinoid type-1 receptor; DRG; dorsal root ganglion; GFAP; glial fibrillary acidic protein; Iba1; ionized calcium-binding adapter molecule 1; MPE; maximum-possible-effect; mSNI; modified spared nerve injury; PWT; paw withdrawal threshold;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

The effects of an intraperitoneal single low dose of ketamine in attenuating the postoperative skin/muscle incision and retraction-induced pain related to the inhibition of N-methyl-d-aspartate receptors in the spinal cord

Keywords: آستانه برداشتن پا; CPOP; chronic postoperative pain; NMDA; N-methyl-d-aspartate; SMIR; skin/muscle incision and retraction; PWMT; paw withdrawal threshold; PWTL; paw withdrawal latency; CaMKII; calcium/calmodulin-dependent kinase II; PKA; protein kinase A; PKC; protein kina

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

PKA is required for the modulation of spinal nociceptive information related to ephrinB-EphB signaling in mice

Keywords: آستانه برداشتن پا; ANOVA; analysis of variance; cAMP; cyclic adenosine monophosphate; CCI; chronic constrictive injury; DMSO; dimethyl sulfoxide; DRG; dorsal root ganglion; NMDA; N-methyl-d-aspartate; CREB; cAMP-response element-binding protein; p-CREB; phosphorylated cAMP-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat

Keywords: آستانه برداشتن پا; C-LTMs; C-low-threshold mechanoreceptors; DRG; dorsal root ganglia; KO; knockout; MIA; monosodium iodoacetate; NSAIDs; non-steroidal anti-inflammatory drugs; OA; osteoarthritis; PWF; paw withdrawal frequency; PWT; paw withdrawal threshold; RM ANOVA; repea

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

Keywords: آستانه برداشتن پا; ACC; the anterior cingulate cortex; AMPAR; a-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptor; ANOVA; analysis of variance; AUC; area under the time-course curve; BDNF; brain-derived neurotrophic factor; CREB; cAMP response element-binding p

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

Activation of spinal GABAB receptors normalizes N-methyl-D-aspartate receptor in diabetic neuropathy

Keywords: آستانه برداشتن پا; NMDA; N-methyl-D-aspartate; NMDAR; N-methyl-D-aspartate receptor; PWT; paw withdrawal threshold; STZ; streptozotocin; CREB; cAMP response element-binding; p-CREB; phosphorylated CREB; Diabetic neuropathic pain; Spinal dorsal horn; GABAB receptor; Glutamat

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model

Keywords: آستانه برداشتن پا; ANOVA; analysis of variance; CCI; chronic constriction injury; 2-DMPI; 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole; GABA; γ-amino butyric acid; 4-HQ; 4-hydroxyquinoline; 5-HT; 5-hydroxytryptamine; ID50; 50% inhibitory dose; Imax; maximum inhibition

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportmTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury

Keywords: آستانه برداشتن پا; CFA; complete Freund's adjuvant; DRG; dorsal root ganglion; mTOR; mammalian target of rapamycin; PWL; paw withdrawal latency; PWT; paw withdrawal threshold; RT; room temperature; S6K1; p70 ribosomal S6 protein kinase 1; SNL; spinal nerve ligation; mTOR; I

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Reduced expression of pain mediators and pain sensitivity in amyloid precursor protein over-expressing CRND8 transgenic mice

Keywords: آستانه برداشتن پا; AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; β-amyloid; CFA; complete Freud's adjuvant; CGRP; calcitonin gene-related peptide; DAB; 3,3′-diaminobenzidine; DRG; dorsal root ganglion; IB4; isolectin-4; i.pl.; intraplantar; NGS; norma

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Up-regulation of spinal microglial Iba-1 expression persists after resolution of neuropathic pain hypersensitivity

Keywords: آستانه برداشتن پا; CR-3; complement receptor-3; Iba-1; ionized calcium-binding adapter protein; PWT; paw withdrawal threshold; SNT; spinal nerve transection; Inflammation; Nerve injury; Rat; Spinal cord; Pain mechanisms;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides

Keywords: آستانه برداشتن پا; CGRP; calcitonin gene related peptide; CaV2.2; N-type voltage-gated Ca2+ channel; CBD; Ca2+ channel binding domain; CRMP2; collapsin response mediator protein 2; CPP; cell penetrating peptide; CNS; central nervous system; ω-CTX; omega-conotoxin; DIV; day

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Estimating Efficacy and Drug ED50's Using von Frey Thresholds: Impact of Weber's Law and Log Transformation

Keywords: آستانه برداشتن پا; Pain; von Frey filament; paw withdrawal threshold; ED50

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Differential adaptive changes on serotonin and noradrenaline transporters in a rat model of peripheral neuropathic pain

Keywords: آستانه برداشتن پا; 5-HTT; serotonin transporter; NAT; noradrenaline transporter; SNL; spinal nerve ligation; PWT; paw withdrawal threshold; PPWT; paw-pressure withdrawal threshold; HPA; hypothalamic-pituitary-adrenal; Neuropathic pain; Spinal nerve ligation; Serotonin t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter

Keywords: آستانه برداشتن پا; BSA; bovine serum albumin; CNS; central nervous system; EAAT; excitatory amino acid transporter; GFAP; glial fibrillary acidic protein; IR; immunoreactivity; LPAG; lateral PAG; PAG; periaqueductal gray matter; PB; phosphate buffer; PLSD; protected least s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat

Keywords: آستانه برداشتن پا; ANOVA; one-way analysis of variance; AUC; area under the curve; ELISA; enzyme-linked immunosorbent assay; IL-1β; interleukin-1β; MFW; mean frequency of withdrawal; PWF; paw withdrawal frequency; PWT; paw withdrawal threshold; TNF-α; tumor necrosis fact

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress

Keywords: آستانه برداشتن پا; CNS; central nervous system; d-Gi; dorsal portion of nucleus reticularis gigantocellularis; DMH; dorsomedial nucleus of the hypothalamus; DRN; dorsal raphe nucleus; ERK; extracellular signal-regulated kinase; GABA; gamma-aminobutyric acid; GiA; nucleus re

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Effects of the transient receptor potential vanilloid 1 antagonist A-425619 on body temperature and thermoregulation in the rat

Keywords: آستانه برداشتن پا; hyperthermia; inflammation; capsaicin; AEA; anandamide; CFA; complete Freud's adjuvant; MPN; medial preoptic nucleus; PO/AH; preoptic/anterior hypothalamus; PWT; paw withdrawal threshold; SCN; suprachiasmatic nucleus; Tb; body temperature; TRPV1; transien

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Activation of microglia and p38 mitogen-activated protein kinase in the dorsal column nucleus contributes to tactile allodynia following peripheral nerve injury

Keywords: آستانه برداشتن پا; neuropathic pain; spinal nerve ligation; gracile nucleus; spinal cord; immunohistochemistry; behavior; ABC; avidin-biotin complex; ANOVA; analysis of variance; COX-2; cyclooxygenase-2; ERK; extracellular signal-regulated kinase; GFAP; glial fibrillary a

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Spinal nerve ligation-induced activation of nuclear factor kappaB is facilitated by prostaglandins in the affected spinal cord and is a critical step in the development of mechanical allodynia

Keywords: آستانه برداشتن پا; NFκB; spinal prostaglandins; spinal nerve ligation; spinal hyperexcitability; allodynia; cyclooxygenase; AFRR; A-fiber-mediated reflex responses; ANOVA; analysis of variance; CFRR; C-fiber-mediated reflex responses; COX; cyclooxygenase; COX-1; cyclooxyge

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Plasticity in intact Aδ- and C-fibers contributes to cold hypersensitivity in neuropathic rats

Keywords: آستانه برداشتن پا; peripheral neuropathy; sensitization; TRPA1; TRPM8; neuropathic pain; cold allodynia; ADM; Aδ-mechanical unit; ADMC; Aδ-mechanocold unit; ADMH; Aδ-mechanoheat unit; ADMHC; Aδ-mechanoheat-cold unit; CM; C-mechanoreceptor unit; CMC; C-mechanocold unit;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Organizational and activational effects of testosterone on carrageenan-induced inflammatory pain and morphine analgesia

Keywords: آستانه برداشتن پا; arthritis; gonadal; hormone; opioid; nociception; hyperalgesia; adult GDX-oil; adult gonadectomized, oil implant; adult GDX-T; adult gonadectomized, testosterone implant; adult sham-oil; sham gonadectomized, oil implant; adult sham-T; sham gonadectomized,

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه