Antinociceptive evaluation of ceftriaxone and minocycline alone and in combination in a neuropathic pain model in rat

► We model sciatic nerve chronic constriction injury in rat. ► Cold anti-allodynia effects of ceftriaxone were potentiated by minocycline. ► Mechanical anti-allodynia effects of ceftriaxone were potentiated by minocycline. ► Spinal proinflammatory cytokines were decreased by ceftriaxone and combination therapy. ► Gabapentin was not accompanied with cytokine levels attenuation.