
Identification of the Syk kinase inhibitor R112 by a human mast cell screen
Keywords: تریپتاز; Syk; Fc receptors; IgE; histamine; tryptase; cytokines; mast cells; allergic rhinitis; small molecule inhibitor; steroidsCHMC, Cultured human mast cells; DMSO, Dimethyl sulfoxide; EC50, Effective concentration for 50% inhibition; ERK, Extracellular signal