کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9157950 | 1172472 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mast cell tryptase: a new biomarker in patients with stable coronary artery disease
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Mast cells may participate actively in the inflammatory process of atherosclerotic plaques by releasing proteolytic enzymes and various other pro-inflammsatory substances. We hypothesized that increased levels of mast cell tryptase, could be an important biomarker in patients with stable coronary artery disease (CAD). We measured tryptase in 102 patients without acute coronary syndromes undergoing cardiac catheterization. Patients with significant CAD [â¥50% stenosis in â¥1 artery (n = 66)] had significantly higher serum tryptase than patients with normal angiography (n = 13) or non-significant CAD [<50% stenosis (n = 23)]. The median, 25th and 75th percentiles for tryptase in these two groups were 8.38 (6.4 and 10.7) μg/L versus 6.78 (5.61 and 9.72) μg/L, p = 0.014. Patients in the highest quartile of tryptase levels had a 4.3-fold risk for CAD [Odds ratio (OR): 4.3; 95% confidence interval (CI): 1.08-17.19; p = 0.04]. In a multivariate regression analysis, tryptase remained an independent predictor for CAD along with age (OR: 1.178; 95% CI: 1.021-1.359, p = 0.025). High circulating tryptase levels may be a result of chronic low-grade inflammatory activity present in atherosclerotic plaques. Tryptase measurements may emerge as a novel way of identifying asymptomatic patients with CAD, and represent a new biomarker of therapeutic efficacy in patients with CAD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 178, Issue 2, February 2005, Pages 381-386
Journal: Atherosclerosis - Volume 178, Issue 2, February 2005, Pages 381-386
نویسندگان
Efthymios N. Deliargyris, Bharathi Upadhya, David C. Sane, Gregory J. Dehmer, Joseph Pye, Sidney C. Jr., William S. Boucher, Theoharis C. Theoharides,