Keywords: TTX، تترودوتوکسین; PND, postnatal day; sEPSC, spontaneous excitatory postsynaptic current; SG, substantia gelatinosa; sIPSC, spontaneous inhibitory postsynaptic current; TGOT, [Thr4, Gly7]-oxytocin; TTX, tetrodotoxin; VH, holding potentialOxytocin; Excitatory transmission;
مقالات ISI TTX، تترودوتوکسین (ترجمه نشده)
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Keywords: TTX، تترودوتوکسین; Nav1.7 voltage-gated sodium channel; Cough; Benzonatate; Local anesthetic; Patch clamp; High performance liquid chromatography mass spectrometryCAD, catecholamine A differentiated; Na+, sodium ion; BABA, 4(butylamino)benzoic acid; TTX, tetrodotoxin; PABA,
Keywords: TTX، تترودوتوکسین; AFB, aflatoxins B; STEC, Shiga toxin-producing Escherichia coli; STX, saxitoxin; TTX, tetrodotoxin; BTX, batrachotoxinsMilitary toxins; Trichothecenes; Venom toxins; Bioweapons; Toxicity
Characterization of ion channels on subesophageal ganglion neurons from Chinese tarantula Ornithoctonus huwena: Exploring the myth of the spider insensitive to its venom
Keywords: TTX، تترودوتوکسین; Chinese tarantula; Toxin; Adaptive insensitivity; Calcium channel; Potassium channel; Sodium channel; Whole-cellHWTX, Huwentoxin; ICK, inhibitor cystine knot; DRG, dorsal root ganglion; TTX, tetrodotoxin; TTX-S, TTX-sensitive; IC50, median inhibitory conc
Molecular determinant for the tarantula toxin Jingzhaotoxin-I slowing the fast inactivation of voltage-gated sodium channels
Keywords: TTX، تترودوتوکسین; Jingzhaotoxin-I; Voltage-gated sodium channels; Inactivation; MutationJZTX, Jingzhaotoxin; VGSCs, voltage-gated sodium channels; TTX, tetrodotoxin; ICK, inhibitor cystine knot; RP-HPLC, reverse-phase high pressure liquid chromatography; MALDI-TOF, matrix
How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?
Keywords: TTX، تترودوتوکسین; AKAP, A kinase anchoring protein; GPCR, G protein-coupled receptors; NCX, sodium-calcium exchanger; NHE-1, type 1 Na +/H + exchanger; PKA, protein kinase A; PKC, protein kinase C; TTX, tetrodotoxin; VGSC, voltage-gated sodium channel, pore forming α subun
Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons
Keywords: TTX، تترودوتوکسین; DA, dopamine; DAG, diacylglycerol; IP3, inositol-1,4,5-phosphate 3; PI, phosphatidylinositol; PKA, protein kinase A; PKC, protein kinase C; PLC, phospholipase C; SPNs, spiny projection neurons; TTX, tetrodotoxin; VGSCs, voltage-gated sodium channelsSKF839
Biochemical and pharmacological characterization of three toxic phospholipase A2s from Daboia russelii snake venom
Keywords: TTX، تترودوتوکسین; PLA2, phospholipase A2; NMDA, N-methyl D-aspartic acid; PC, phosphatidylcholine; TTX, tetrodotoxin; mEPSC, miniature excitatory postsynaptic currents; GABA, gamma amino butyric acid; HEPES, 4-(-2-hydroxyethyl)-1-piperanineethanesulfonic acid; EGTA, ethyle
Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy
Keywords: TTX، تترودوتوکسین; AV, atrioventricular; DMSO, dimethylsulfoxide; GFP, green fluorescent protein; LQTS, long QT syndrome; TTX, tetrodotoxin; WT, wild-typeSCN5A mutation; Cardiomyopathy; Electrophysiology; Amiodarone
Etomidate evokes synaptic vesicle exocytosis without increasing miniature endplate potentials frequency at the mice neuromuscular junction
Keywords: TTX، تترودوتوکسین; α-BGT, alpha-bungarotoxin; ACh, acetylcholine; EGTA, etilenoglicol-bis-β-aminoetil éster; GABA, γ-amino butyric acid; MEPP, miniature end plate potential; TTX, tetrodotoxin; NMJ, neuromuscular junctionEtomidate; Neuromuscular junction; FM1-43; Synaptic ve
Effects of estradiol on voltage-gated sodium channels in mouse dorsal root ganglion neurons
Keywords: TTX، تترودوتوکسین; 17β-E2, 17β-estradiol; TTX, tetrodotoxin; TTX-S, TTX-sensitive; TTX-R, TTX-resistant; PKC, protein kinase C; PKA, protein kinase AEstradiol; Voltage-gated sodium channels; Dorsal root ganglion neurons
Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats
Keywords: TTX، تترودوتوکسین; Magnolol; Magnolia officinalis; Colonic motility; Smooth muscle cells; L-type Ca2+ channelsACh, acetylcholine; TTX, tetrodotoxin; l-NAME, Nώ-nitro-l-arginine methyl ester; NO, nitric oxide; VGCC, voltage-sensitive Ca2+ channels; CCh, carbachol; 5-HT, sero
Berberine improves neurogenic contractile response of bladder detrusor muscle in streptozotocin-induced diabetic rats
Keywords: TTX، تترودوتوکسین; DCP, Diabetic cystopathy; DM, diabetes mellitus; STZ, streptozotocin; NANC, nonadrenergic noncholinergic; BBR, berberine; ATP, adenosine triphosphate disodium salt; TTX, tetrodotoxin; K–H, Krebs–Henseleit; EFS, electric field stimulation; FRC, frequency-r
Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats
Keywords: TTX، تترودوتوکسین; DA, dopamine; DPC, diphenylamine-2, 2′-dicarboxylic acid; IBMX, 3-isobutyl-1-methylxanthine; ISC, short-circuit current; K-HS, Krebs-Henseleit solution; TEA, tetraethylammonium; TTX, tetrodotoxin; cAMP, cyclic adenosine monophosphate
Ca2+ channel currents in dorsal root ganglion neurons of P/Q-type voltage-gated Ca2+ channel mutant mouse, rolling mouse Nagoya
Keywords: TTX، تترودوتوکسین; ω-ATX, ω-agatoxin IVA; 4-AP, 4-aminopyridine; ω-CTX, ω-conotoxin GVIA; DRG, dorsal root ganglion; NMDG, N-methyl-d-glucamine; TEA, tetraethylammonium; TTX, tetrodotoxin; VGCC, voltage-gated Ca2+ channelω-Agatoxin IVA; ω-Conotoxin GVIA; Patch clamp; Ba2+ c
Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine
Keywords: TTX، تترودوتوکسین; Sodium channel; Tetrodotoxin; Neuropathic pain; Dorsal root ganglionDRG, dorsal root ganglion; TTX, tetrodotoxin; INa, Na+ current; AP, action potential
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
Keywords: TTX، تترودوتوکسین; Nav, voltage-gated sodium channel; TTX, tetrodotoxin; ProTxII, β/ω-theraphotoxin-Tp2a; Ca2+, calcium ion; DMEM, Dulbecco's Modified Eagle's Medium; FBS, foetal bovine serum; PBS, phosphate buffered saline; PSS, physiological salt solution; HBS, HEPES-buff
Inhibition of presynaptic Na+/K+-ATPase reduces readily releasable pool size at the avian end-bulb of Held synapse
Keywords: TTX، تترودوتوکسین; NKA, Na+/K+-ATPase; DHO, dihydroouabain; RRP, readily releasable pool; Pvr, vesicular release probability; CV, coefficient of variation; NM, nucleus magnocellularis; ANF, auditory nerve fiber; TTX, tetrodotoxin; VGLUT2, vesicular glutamate transporter 2;
Glucagon-like peptide-1 relaxes gastric antrum through nitric oxide in mice
Keywords: TTX، تترودوتوکسین; GLP-1, glucagon-like peptide-1; GLP-1R, GLP-1 receptor; l-NAME, Nω-nitro-l-arginine methyl ester; NO, nitric oxide; NOS, nitric oxide synthase; TTX, tetrodotoxin; CCh, carbachol; RT-PCR, reverse-transcriptase polymerase chain reactionGlucagon like peptide
Bilirubin enhances neuronal excitability by increasing glutamatergic transmission in the rat lateral superior olive
Keywords: TTX، تترودوتوکسین; sEPSCs, spontaneous excitatory postsynaptic currents; mEPSCs, miniature excitatory postsynaptic currents; sIPSCs, spontaneous inhibitory postsynaptic currents; IGABA, GABA-activated currents; Iglu, glutamate-activated currents; TTX, tetrodotoxin; APV, d,l
Inhibition of voltage-gated sodium channels by bisphenol A in mouse dorsal root ganglion neurons
Keywords: TTX، تترودوتوکسین; BPA, bisphenol A; TTX, tetrodotoxin; TTX-S, TTX-sensitive; TTX-R, TTX-resistant; PKC, protein kinase C; PKA, protein kinase ABisphenol A; Voltage-gated sodium channels; Dorsal root ganglion neurons; Protein kinase C; Protein kinase A
Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes
Keywords: TTX، تترودوتوکسین; Sodium current; Intercalated disc; Nav1.5ID, intercalated disc; INa, sodium current; TNF-α, tumor necrosis factor-alpha; TTX, tetrodotoxin; TTX-R, TTX-resistant; TTX-S, TTX-sensitive; VGSCs, voltage-gated sodium channels
Fos expression induced by activation of NMDA and neurokinin-1 receptors in the trigeminal subnucleus caudalis in vitro: Role of protein kinases
Keywords: TTX، تترودوتوکسین; Vc, trigeminal subnucleus caudalis; Vi, trigeminal subnucleus interpolaris; TTX, tetrodotoxin; Sar9, [Sar9,Met(O2)11]-SP; ChCl, chelerythrine chlorideFos; Trigeminal system; PKA; PKC; NK1 receptor; NMDA receptor
Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons
Keywords: TTX، تترودوتوکسین; TLE, temporal lobe epilepsy; Na, sodium; mEC, medial entorhinal cortex; TTX, tetrodotoxin; axon initial segment, AIS; action potential, AP; persistent sodium current, INaP; resurgent sodium current, INaRSodium channels; Temporal lobe epilepsy; Entorhinal
Clonidine, an α2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus
Keywords: TTX، تترودوتوکسین; Ambiguus; Clonidine; Adrenergic; Cardiac; Vagal; ParasympatheticCVNs, cardioinhibitory vagal neurons; IPSCs, inhibitory postsynaptic currents; EPSCs, excitatory postsynaptic currents; mEPSCs, miniature EPSCs; mIPSCs, miniature IPSCs; TTX, tetrodotoxin
Amitriptyline inhibits currents and decreases the mRNA expression of voltage-gated sodium channels in cultured rat cortical neurons
Keywords: TTX، تترودوتوکسین; CSD, cortical spreading depression; FHM, familial hemiplegic migraine; TTX, tetrodotoxin; AMI, amitriptylineMigraine; Cortical spreading depression; Amitriptyline; Cortical neurons; Patch clamp; RT-PCR
Syndecan-4 and β1 integrin are regulated by electrical activity in skeletal muscle: Implications for cell adhesion
Keywords: TTX، تترودوتوکسین; HSPGs, Heparan sulfate proteoglycans; TTX, Tetrodotoxin; anti-Δ-HS, Anti-heparan sulfate epitope; PI3K/Akt, Phosphatidylinositol 3-kinase/AktSyndecans; Heparan sulfate proteoglycans; Skeletal muscle; Costameres; Cell adhesion; TTX
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain
Keywords: TTX، تترودوتوکسین; TTx, tetrodotoxin; TTx-r, tetrodotoxin-resistant; VGSC, voltage gated sodium channels; DRG, dorsal root ganglia; ip, intraperitoneal; iv, intravenous; po, per os; F, bioavailability; T1/2, half-life; Clp, plasma clearance; CEREP, cell-surface receptors, i
Neurogenic contraction of mouse rectum via the cyclooxygenase pathway: Changes of PGE2-induced contraction with dextran sulfate sodium-induced colitis
Keywords: TTX، تترودوتوکسین; PGs, prostaglandins; GI, gastrointestinal; COXs, cyclooxygenases; ACh, acetylcholine; IBD, inflammatory bowel disease; UC, ulcerative colitis; DSS, dextran sulfate sodium; ES, electrical stimulation; TTX, tetrodotoxin; 5-HT, 5-hydroxytryptamineMouse rectu
Positive inotropic effects of Tityus cambridgei and T. serrulatus scorpion venoms on skeletal muscle
Keywords: TTX، تترودوتوکسین; CRO, cromakalim; Tc, Tityus cambridgei venom; Ts, Tityus serrulatus venom; TTX, tetrodotoxin; SEM, standard error of the meanContractile force; Cromakalim; Mouse phrenic nerve–diaphragm; Tetrodotoxin; Tityus serrulatus venom
Thermal and chemical unfolding and refolding of a eukaryotic sodium channel
Keywords: TTX، تترودوتوکسین; CD, circular dichroism; DDM, dodecyl maltoside; TTX, tetrodotoxin; VGSC, voltage-gated sodium channel; cmc, critical micelle concentrationVoltage-gated sodium channel; Protein folding; Membrane protein; Secondary structure; Circular dichroism spectroscopy
High spatial resolution studies of muscarinic neuroeffector junctions in mouse isolated vas deferens
Keywords: TTX، تترودوتوکسین; cholinergic innervation; mouse vas deferens; smooth muscle Ca2+ transientsACh, acetylcholine; AChE, acetylcholinesterase; NA, noradrenaline; NOS, nitric oxide synthase; TTX, tetrodotoxin; α,β-MeATP, α,β methylene ATP
Jingzhaotoxin-IX, a novel gating modifier of both sodium and potassium channels from Chinese tarantula Chilobrachys jingzhao
Keywords: TTX، تترودوتوکسین; JZTX-IX; Tarantula toxin; Voltage-gated sodium channel; Voltage-gated potassium channel; Closed configurationJZTX, Jingzhaotoxin; ICK, inhibitor cystine knot; Nav channel, voltage-gated sodium channel; DRG, dorsal root ganglion; TTX, tetrodotoxin; TTX-R,
Two critical residues in p-loop regions of puffer fish Na+ channels on TTX sensitivity
Keywords: TTX، تترودوتوکسین; Sodium channel; Puffer fish; TetrodotoxinWT, wild type; Nav, voltage-gated Na+ channel; TTX, tetrodotoxin; STX, saxitoxin; HEK, human embryonic kidney; INa, Na+ current; Kd, dissociation constants; koff, dissociation rate constant; kon, association rate c
Differential effects of glutamate transporter inhibitors on the global electrophysiological response of astrocytes to neuronal stimulation
Keywords: TTX، تترودوتوکسین; GLT-1, glutamate transporter 1; GLAST, glutamate–aspartate transporter; TBOA, dl-threo-β-benzyloxyaspartate; DHK, dihydrokainate; TTX, tetrodotoxin; Kir, inwardly rectifying K+ channels; I–V, current–voltage; ITrsp, glutamate transporter current; ITail, p
TTX-R Na+ current-reduction by celecoxib correlates with changes in PGE2 and CGRP within rat DRG neurons during acute incisional pain
Keywords: TTX، تترودوتوکسین; COX, Cyclooxygenase; DRG, dorsal root ganglion; PGE2, prostaglandin E2; TTX, tetrodotoxin; CGRP, calcitonin gene-related proteinCelecoxib; Dorsal root ganglion; Sodium channel; Prostaglandin E2; Calcitonin gene-related protein
Localisation and function of nerves in the aortic root
Keywords: TTX، تترودوتوکسین; STJ, Sinotubular junction; TTX, Tetrodotoxin; PBS, Phosphate buffered saline; BSA, Bovine serum albumin; NOS, Nitric oxide synthase; ChAT, Choline acetyl transferase.Heart valves; Nitric oxide; Nerves; Sympathetic; Parasympathetic; Porcine
Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms
Keywords: TTX، تترودوتوکسین; Spider venom; Neurotoxin; Inhibitor cystine knot; Sodium channel inhibitorHPLC, high-performance liquid chromatography; MALDI, matrix-assisted laser desorption ionization; MS, mass spectrometry; STX, saxitoxin; TFA, trifluoroacetic acid; TTX, tetrodotoxin
Substrate-mediated regulation of γ-aminobutyric acid transporter 1 in rat brain
Keywords: TTX، تترودوتوکسین; GABA receptor; GAT1; Recycling; Trafficking; UptakeGABA, γ-aminobutyric acid; GAT1, γ-aminobutyric acid transporter 1; PKC, protein kinase C; SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor; TTX, tetrodotoxin; GLUT4, glucose t
Novel mRNA isoforms of the sodium channels Nav1.2, Nav1.3 and Nav1.7 encode predicted two-domain, truncated proteins
Keywords: TTX، تترودوتوکسین; DRG; brain; alternative splicing; Scn2a; Scn3a; Scn9abp, base pairs; DRG, dorsal root ganglia; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; kb, kilobases; nt, nucleotides; PTC, premature termination codon; RT, reverse transcription; TTX, tetrodotoxin
Glial-toxin-mediated disruption of spinal cord locomotor network function and its modulation by 5-HT
Keywords: TTX، تترودوتوکسین; glial; lamprey; modulation; spinal cord; CPGANOVA, analysis of variance; CV, coefficient of variation; EPSP, excitatory postsynaptic potential; mEPSP, miniature EPSP; PP, paired pulse; TTX, tetrodotoxin
Isolation and characterization of “Reprotoxin”, a novel protein complex from Daboia russelii snake venom
Keywords: TTX، تترودوتوکسین; Protein complex; Reprotoxin; Presynaptic neurotoxin; Daboia russelii venomPLA2, phospholipase A2; NO, nitric oxide; NMDA, N-methyl d-aspartic acid; PC, phosphatidylcholine; EAT, Ehrlich ascites tumor; TTX, tetrodotoxin; mEPSC, miniature excitatory postsyn
Isolation and characterization of a T-superfamily conotoxin from Conus litteratus with targeting tetrodotoxin-sensitive sodium channels
Keywords: TTX، تترودوتوکسین; DRG, dorsal root ganglion; TTX, tetrodotoxin; MALDI-TOF, matrix assisted laser desorption/ionization time-of-flight; TFA, trifluoroacetic acid; HPLC, high performance liquid chromatography; HEPES, N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid; TEA, t
Multiple conductances are modulated by 5-HT receptor subtypes in rat subthalamic nucleus neurons
Keywords: TTX، تترودوتوکسین; 5-HT; subthalamic nucleus; brain slice; patch clamp; burst firingI–V, current-voltage; NMDA, N-methyl-d-aspartate; STN, subthalamic nucleus; TTX, tetrodotoxin
Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat
Keywords: TTX، تترودوتوکسین; BDNF, brain-derived neurotrophic factor; NGF, nerve growth factor; GLU, glutamate; DA, dopamine; TTX, tetrodotoxin; Trk, tyrosine kinase; CNS, central nervous system; SN, substantia nigra; AUC, area under the curve; HPLC, high performance liquid chromatog
Role of acetylcholine transmission in nucleus accumbens and ventral tegmental area in heroin-seeking induced by conditioned cues
Keywords: TTX، تترودوتوکسین; rat; craving; abstinence; acetylcholinesterase inhibitor; reinstatement; conditioningAChE, acetylcholinesterase; aCSF, artificial cerebrospinal fluid; CS, conditioned stimuli; NAc, nucleus accumbens; TTX, tetrodotoxin; VTA, ventral tegmental area
Characterization of the excitatory mechanism induced by Jingzhaotoxin-I inhibiting sodium channel inactivation
Keywords: TTX، تترودوتوکسین; Sodium channels; Spider toxin; Dorsal root ganglia; Whole-cell recordingdTc, d-Tubocurarine; DRG, dorsal root ganglia; ICK, inhibitor cystein knot; JZTX, Jingzhaotoxin; TTX, tetrodotoxin; TTX-R, tetrodoxin resistant; TTX-S, tetrodotoxin sensitive; VGSC (a
Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression
Keywords: TTX، تترودوتوکسین; BDNF, brain-derived neurotrophic factor; GAP-43, growth-associated protein 43; DRG, dorsal root ganglia; ATF3, activated transcription factor 3; TTX, tetrodotoxin; FR, fluororuby; FG, fluorogoldSensory neuron; Electrical stimulation; Regeneration; Periphe
The μO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3
Keywords: TTX، تترودوتوکسین; NaV channels, voltage-gated sodium channels; TTX, tetrodotoxin; STX, saxitoxinSodium channel; Conotoxin; Neurotoxin; Patch clamp; Channel block; Pain
The systemic application of diazepam facilitates the reacquisition of a well-balanced vestibular function in a unilateral vestibular re-input model with intracochlear tetrodotoxin infusion using an osmotic pump
Keywords: TTX، تترودوتوکسین; TTX, tetrodotoxin; VOR, vestibuloocular reflex; DP, directional preponderance of the nystagmus; MVN, medial vestibular nucleus; GABA, γ-aminobutyric acidVestibuloocular reflex; Directional preponderance of the nystagmus; Tetrodotoxin; Diazepam; Vestibular