کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4341802 1295846 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Glial-toxin-mediated disruption of spinal cord locomotor network function and its modulation by 5-HT
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Glial-toxin-mediated disruption of spinal cord locomotor network function and its modulation by 5-HT
چکیده انگلیسی

While it is established that glial cells actively influence neuronal and synaptic properties, the functional effects of glial–neuronal interactions are still not well understood. To address the role of glia at the network level we have examined the effects of the specific gliotoxin l-aminoadipic acid on the locomotor network output and cellular and synaptic properties in the lamprey spinal cord.The gliotoxic effect of aminoadipic acid was associated with a specific depolarization of glial cells. Aminoadipic acid depolarized the membrane potential of spinal cord neurons, suggesting a functional link between glia and neurons. The depolarization was significantly reduced by glutamate receptor antagonists in adults, but by gap junction blockers in larvae, suggesting a developmental difference in glial–neuronal interactions. Aminoadipic acid also reduced the amplitude of monosynaptic excitatory postsynaptic potentials (EPSPs), an effect that was not associated with changes in the presynaptic release probability or postsynaptic response to glutamate.These cellular and synaptic effects of aminoadipic acid were associated with disruption of the locomotor network output. This could not be accounted for by changes in glutamate uptake or potassium buffering by glia, suggesting a direct role for glia in the network. Interestingly, we found that the aminoadipic acid–evoked disruption of network activity and reduction of monosynaptic EPSP amplitudes did not occur in the presence of the endogenous spinal modulator 5-HT.These results thus provide evidence for an active functional role for glial cells in spinal cord locomotor networks, and suggest a potential glial modulatory effect of 5-HT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 153, Issue 4, 2 June 2008, Pages 1332–1343
نویسندگان
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