Keywords: Thioredoxins; Cholestasis; Oxidative stress; Cholangiocyte; ALT; Alanine aminotransferase; BDL; Bile duct ligation; GCLC; Gamma-glutamylcysteine; GSH; Reduced glutathione; GST; Glutathione S-Transferase; HO-1; Heme Oxygenase 1; 4-HNE; 4-hydroxy-2-nonenal;
مقالات ISI (ترجمه نشده)
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Keywords: AMPK; OGT; PPARδ; SIRT3; TXNIP;
Keywords: myocardial inflammation; oxidative stress; poly(ADP-ribose) polymerase-1; Takotsubo cardiomyopathy; 3AB; 3-aminobenzamide; ANOVA; analysis of variance; ISO; isoproterenol; LV; left ventricular; NFκB; nuclear factor kappa B; NO; nitric oxide; NOS; nitric
Keywords: Proliferative diabetic retinopathy; TXNIP; Angiogenesis; VEGFR2; Akt/mTOR;
Keywords: AGEs; advanced glycation end-products; CAD; coronary artery disease; CRP C; reactive protein; CTGF; connective tissue growth factor; DAG; diacyl glycerol; DCM; diabetic cardio-myopathy; DFU; diabetic foot ulcer; eNOS; endothelial nitric oxide synthase; FO
Keywords: α-MSH; α-melanocyte stimulating hormone; AGRP; agouti related protein; ARC; arcuate nucleus of hypothalamus; ATF; activating transcription factor; BBB; blood-brain barrier; CRH; corticotropin-releasing hormone; CSF; cerebrospinal fluid; Cys; cysteine; D
Keywords: AF; S-triethyl phosphine gold(I)-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside (Auranofin); AP-1; activator protein 1; ARE; antioxidant response element; ASK1; apoptosis signal-regulating kinase 1; [Au(dppe)2]Cl; [bis(diphenylphosphino)ethane]gold(I)
Keywords: ChREBP; NF-κB; OGT; PARP; TXNIP;
Keywords: AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; BNIP3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; CHOP; C/EBP homologous protein; DRP1; dynamin-related protein 1; FIS1; fission protein 1; GRP78; 78Â kDa glucose-regulat
Keywords: TXNIP; Aortic endothelial cells; Endothelial dysfunction; Cardiovascular disease; Diabetes mellitus;
Keywords: FBE; Actin free barbed ends; ASC; Apoptosis-associated Speck protein with CARD domain; CT; citrate transporter; ME; cytosolic NADP-dependent malic enzyme; DCF-DA; 2;7-dihydrodichloro-fluorescein diacetate; FAK; focal adhesion kinase; ER; endoplasmic retic
Keywords: AF; atrial fibrillation; CVA; cerebrovascular accident; MPO; myeloperoxidase; NO; nitric oxide; LVEF; left ventricular ejection fraction; ADMA; asymmetric dimethylarginine; SDMA; symmetric dimethylarginine; TSP-1; thrombospondin-1; Txnip; thioredoxin-inte
Keywords: α-TOS; α-tocopheryl succinate; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer susceptibility gene 1; CDK4; cyclin-dependent kinase 4; CEA; carcinoembryonic antigen; CSC(s); cancer stem(-like) cell(s); CTGF; connective tissue growth factor (CCN2)
Keywords: Heparin; HCC; TXNIP; ChoRE; ChoRE associated proteins;
Keywords: EMT; epithelial to mesenchymal transition; TXNIP; thioredoxin-interacting protein; TRX; thioredoxin; DN; diabetic nephropathy; TGF-β; transforming growth factor-β; HG; high glucose; ROS; reactive oxygen species; AGEs; advanced glycation end products; An
Keywords: b-SO6; biotinylated saporin-6; BCA; bicinchoninic acid; BFU-e; burst forming unit-erythroid; BHLHB2; basic-helix-loop-helix transcription factor B2; BMMC; bone marrow mononuclear cells; CDC14B; dual specificity protein tyrosine phosphatase family; CFU-e;
TXNIP knockdown alleviates hepatocyte ischemia reperfusion injury through preventing p38/JNK pathway activation
Keywords: TXNIP; Hepatic ischemia reperfusion injury; Cell apoptosis; p38/JNK pathway;
Novel approaches in the treatment of diabetic cardiomyopathy
Keywords: ACE; angiotensin convertase enzyme; ACEi; angiotensin convertase enzyme inhibitor; ADP; adenosine di phosphate; AGE; advanced glycation end products; AM; adrenomedullin; AMP; adenosine mono phosphate; ARB; angiotensin receptor blocker; ATP; adenosine tri
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
Keywords: Nuclear factor erythroid 2-related factor 2; Nod-like receptor protein 3 inflammasome; Thioredoxin1; Thioredoxin interacting protein; Inflammation; NLRP3; nod-like receptor protein 3; TXNIP; thioredoxin interacting protein; Trx1; thioredoxin1; Nrf2; nucle
d-galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions
Keywords: d-gal; d-galactose; LECs; lens epithelial cells; HCQ; hydroxychloroquine; ROS; reactive oxygen species; VADC; voltage dependent anion channel; mPTP; mitochondria permeability transition pore; MMP; mitochondrial membrane potential; NAC; N-acetylcysteine; G
TXNIP mediated the oxidative stress response in glomerular mesangial cells partially through AMPK pathway
Keywords: TXNIP; AMPK; Fibronectin; Oxidative stress; Glomerular mesangial cell;
Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice
Keywords: Compound K; Nox1; TXNIP; NLRP3; Diabetic nephropathy; p38;
Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Keywords: ASC; apoptosis-associated speck-like protein; CPT-1; carnitine palmitoyl transferase-1; GST; glutathione S-transferase; HO-1; hemeoxygenase-1; H2O2; hydrogen peroxide; IL; interleukin; Keap1; Kelch-like ECH-associated protein 1; MDA; malondialdehyde; miR-
GLUT1 protects prostate cancer cells from glucose deprivation-induced oxidative stress
Keywords: 2DG; 2-deoxyglcuose; AMPK; AMPK-activated protein kinase; AR; Androgen Receptor; CAT; Catalase; DHA; Dehydroascorbic Acid; G6PG; Glucose-6-phosphate dehydrogenase; GPX; Glutathione peroxidase; GSH; Reduced glutathione; GSSG; Oxidized glutathione; HTLV; Hu
Hypoxia potentiates LPS-induced inflammatory response and increases cell death by promoting NLRP3 inflammasome activation in pancreatic β cells
Keywords: Hypoxia; β cell; Inflammasome; Islet inflammation; Diabetes; TXNIP;
Mapping Txnip: Key connexions in progression of diabetic nephropathy
Keywords: ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;
Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats
Keywords: PPAR-β/δ; GW0742; HI; Apoptosis; miR-17; TXNIP;
Dual Role of EZH2 in Cutaneous Anaplastic Large Cell Lymphoma: Promoting Tumor Cell Survival and Regulating Tumor Microenvironment
Keywords: CD30+LPD; CD30+ lymphoproliferative disease; CTCL; cutaneous T-cell lymphoma; CXCL10; C-X-C motif chemokine ligand 10; CXCR3; C-X-C motif chemokine receptor 3; EZH2; enhancer of zeste homolog; H3K27me3; histone H3 lysine 27 trimethylation; LCT; large-cell
Honokiol alleviates the degeneration of intervertebral disc via suppressing the activation of TXNIP-NLRP3 inflammasome signal pathway
Keywords: Intervertebral disc degeneration; Honokiol; TXNIP; NLRP3; ROS;
Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition
Keywords: miR-200a; microRNA-200a; TXNIP; thioredoxin interacting protein; NLRP3; NOD-like receptor pyrin domain containing 3; ASC; adaptor apoptosis-associated speck-like protein containing CARD; caspase1; cysteinyl aspartate specific proteinase 1; NAFLD; nonalcoh
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood urea nitrogen; BW; body weight; BG; blood glucose; DCFDA; dichlorodihydrofluorescein diacetate; DN; diabetic nephropathy; ECL; enhanced chemiluminescence; EM; electron microscopy;
IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies
Keywords: 2DIR; two-dimensional infra-red spectroscopy; AFM; atomic force microscopy; AGE; advanced glycation end; CD; circular dichroism; CGRP; calcitonin gene-related peptides; DMSO; Dimethyl Sulfoxide; EGCG; epigallocatechin gallate; EPR; electron paramagnetic r
Induction of heme oxygenas-1 attenuates NLRP3 inflammasome activation in lipopolysaccharide-induced mastitis in mice
Keywords: Mastitis; LPS; NLRP3 inflammasome; TXNIP; HO-1;
Thioredoxin-1, redox factor-1 and thioredoxin-interacting protein, mRNAs are differentially expressed in Multiple Sclerosis patients exposed and non-exposed to interferon and immunosuppressive treatments
Keywords: Trx1; Thioredoxin 1; Trx1R; Thioredoxin 1 reductase; Trx2; Thioredoxin 2; Trx2R; Thioredoxin 2 reductase; Txnip; Thioredoxin-interacting protein; Ref-1; Redox factor-1; MS; Multiple Sclerosis; RRMS; Relapsing-Remitting Multiple Sclerosis; SPMS; Secondary
Endogenous hydrogen sulfide-mediated MAPK inhibition preserves endothelial function through TXNIP signaling
Keywords: Endothelial function; Hydrogen sulfide; MAPK; TXNIP;
Research articleEffect of betaine on hepatic insulin resistance through FOXO1-induced NLRP3 inflammasome
Keywords: Betaine; FOXO1; NLRP3 inflammasome; Insulin resistance; Oxidative stress; TXNIP;
Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver
Keywords: ASBT; apical sodium-dependent bile salt transporter; BSEP; bile salt export pump; COX2; cyclooxygenase 2; CYP7A1; cholesterol 7α-hydroxylase; FXR; farnesoid X receptor; HFHC; high fat and high cholesterol; HMGCR; 3-hydroxy-3-methyl glutaryl coenzyme A re
Macrophage migration inhibitory factor interacts with thioredoxin-interacting protein and induces NF-κB activity
Keywords: MIF; TXNIP; NF-κB; HDAC; HeLa cell;
Berberine, an isoquinoline alkaloid suppresses TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and alleviates MSU crystal induced inflammation in rats
Keywords: Berberine; Gouty arthritis; Inflammatory proteins; Nrf2 transcription factor; TXNIP;
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway
Keywords: Senescence; IL-1β; NLRP3 inflammasome; ROS; TXNIP;
Digitoflavone (DG) attenuates LPS-induced acute lung injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP/NLRP3 and NF-κB
Keywords: Acute lung injury; Digitoflavone; Oxidative stress; Inflammation; TXNIP; NF-κB;
Oxidized LDL at the crossroads of immunity in non-alcoholic steatohepatitis
Keywords: 25HC; 25-hydroxycholesterol; 27HC; 27-hydroxycholesterol; 4-HNE; 4-hydroxynonenal; CASP-1; Caspase-1; CD36; cluster of differentiation 36; Col1a1; collagen type 1, alpha 1; CONV-R; conventionally raised; CVD; cardiovascular disease; FA; fatty acid; FXR; f
Modulation of signaling mechanisms in the heart by thioredoxin 1
Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di
Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH
Keywords: ALD; alcoholic liver disease; ALT; alanine aminotransferase; CID; collision-induced dissociation; Cyp2E1; Cytochrome P4502E1; 4-HNE; 4-hydroxy-2-nonenal; 4-ONE; 4-oxononenal; MDA; malondialdehyde; NAFLD; Nonalcoholic fatty liver disease; NASH; Nonalcoholi
1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression
Keywords: 1,25(OH)2D3; 1,25-Dihydroxyvitamin D3; 2DG; 2-Deoxyglucose; ACACA; Acetyl CoA carboxylase A; ACC; Acetyl CoA carboxylase; ACLY; ATP citrate lyase; AMPK; AMP-activated protein kinase; AR; Androgen receptor; CAMKK; Ca2Â +-calmodulin-dependent kinase kinase;
Contiguous gene deletion in HFE2 region (1q21.1) and pathogenic HFE2 mutations in a Chinese hereditary hemochromatosis patient
Keywords: HH; Hereditary hemochromatosis; HFE; hemochromatosis; HJV; hemojuvelin; HFE2; hemochromatosis type 2; HAMP; hepcidin; TfR2; transferrin receptor 2; TS; transferrin saturation; SI; serum iron; SF; serum ferritin; TF; transferrin; HGB; hemoglobin; RET; reti
MicroRNA-20a negatively regulates expression of NLRP3-inflammasome by targeting TXNIP in adjuvant-induced arthritis fibroblast-like synoviocytes
Keywords: MicroRNA-20a; TXNIP; NLRP3-inflammasome; RA;
Biochanin A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
Keywords: Biochanin A; LPS; Nrf2; NLRP3; TXNIP;
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease
Keywords: Diabetic nephropathy; TXNIP; Lipid accumulation; Akt/mTOR; SREBP-1; PPARα;
Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome
Keywords: Cepharanthine; Piperine; Diabetes; Renal injury; NF-κB; TXNIP; NLRP3