Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres
Keywords: U.69.593; [35S]GTPγS; sulfur-35 guanosine-5â²-O-(3-thio)triphosphate; DAMGO; [D-Ala2,MePhe4,Gly-ol5]enkephalin; DPDPE; [D-Pen2,D-Pen5]enkephalin; U69,593; (5α,7α,8β)-(â)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4,5]dec-8-yl]benzeneacetamide; JDTic; Opioids;