دانلود مقالات ISI درباره Ugt1A1 + ترجمه فارسی

نقش گیرنده توکسین 4 در اثر متقابل دارو و دارو بین پلاکتکسل و ویتامیناتان در آزمایشگاهی

Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro

Keywords: PXR; Pregnane X receptor; LPS; Lipopolysaccharide; TLR4; Toll-like receptor 4; DMETs; Drug metabolizing enzymes and transporters; CES; Carboxylesterase; CYP; Cytochrome P450; SN-38; 7-Ethyl-10-hydroxycamptothecin; SN-38G; SN-38 glucuronide; UGT1A1; Uridin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

سهم فارماکوژنتیک در مصرف داروها

The contribution of pharmacogenetics to pharmacovigilance

Keywords: Pharmacogenetics; Pharmacovigilance; Adverse drug reactions; UGT1A1; TPMT; DPYD; CYP2D6; VKORC1/CYP2C9; CYP2C19; HLA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

سلول های بنیادی سرطانی و مقاومت شیمیایی: هوشمندانه ترین حمله را پشت سر می گذارد

Cancer stem cells and chemoresistance: The smartest survives the raid

Keywords: Cancer stem cell; Chemotherapy; Chemoresistance; Targeted therapy; 5-FU; 5-fluorouracil; ABCT; ATP-binding cassette transporter; ALDH; Aldehyde dehydrogenase; AML; Acute myeloid leukemia; ASC; Adult stem cell; BCRP or ABCG; Breast cancer resistance protei

دانلود رایگان متن کامل مقاله ISI 82 صفحه سال انتشار : 2016 سفارش ترجمه

مصرف الکل حاد باعث افزایش بیلی روبین سرم می شود: آنتی اکسیدان آندوژنیک

Acute alcohol consumption elevates serum bilirubin: An endogenous antioxidant

Keywords: Bilirubin; Alcohol; Cardiovascular disease; Alcohol metabolism; Smoking; UGT1A1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

بیلیروبین یدید دی فسفات-گلوکورونوسیل ترانسفراز تغییرات ژنتیکی یک ژنتیک شیر مادر است

Bilirubin Uridine Diphosphate-Glucuronosyltransferase Variation Is a Genetic Basis of Breast Milk Jaundice

Keywords: BMJ; Breast milk jaundice; gtPBREM; Phenobarbital responsive enhancer module; PCR; Polymerase chain reaction; UGT1; UDP-glucuronosyltransferase type 1; UGT1A1; Bilirubin UDP-glucuronosyltransferase 1 family, polypeptide A1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

تجزیه و تحلیل صفات کمی از پلی مورفیسم در دو آنزیم متابولیسم بیلیروبین به سطوح بیلیروبین فیزیولوژیک در نوزادان چینی

Quantitative Trait Analysis of Polymorphisms in Two Bilirubin Metabolism Enzymes to Physiologic Bilirubin Levels in Chinese Newborns

Keywords: FDR; False discovery rate; HMOX1; Heme Oxygenase-1; LD; Linkage disequilibrium; TcB; Transcutaneous bilirubin; UGT1A1; Uridine Diphosphate Glucuronosyl Transferase 1A1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

اختلالات به دست آمده از حمل و نقل و انعقاد بیلیروبین: بینش جدید به مکانیزم های مولکولی و پیامدهای آن

Inherited Disorders of Bilirubin Transport and Conjugation: New Insights Into Molecular Mechanisms and Consequences

Keywords: Crigler-Najjar Syndrome; Hepatic Storage Disease; Glucuronosyl Transferase; Bile Secretion; Kernicterus; ATP; adenosine triphosphate; BSP; bromosulphophthalein; CN; Crigler-Najjar; DJS; Dubin-Johnson syndrome; GS; Gilbert syndrome; ICG; indocyanine

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Identification of second-generation P2X3 antagonists for treatment of pain

Keywords: P2X3; Pain; UGT1A1; Drug-drug interaction; Purinergic receptor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical utility of ABCB1 genotyping for preventing toxicity in treatment with irinotecan

Keywords: Adverse reactions; Pharmacogenetics; SNP; Cancer; UGT1A1; ABC transporters;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Alisma orientale extract exerts the reversing cholestasis effect by activation of farnesoid X receptor

Keywords: Alisma orientale; Cholestasis; Proteomics; Farnesoid X receptor; AOE; Alisma orientale extract; ANIT; α-naphthylisothiocyanate; FXR; farnesoid X receptor; AST; aspartate aminotransferase; ALT; alanine aminotransferase; TBIL; total bilirubin; TBA; intrahe

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro

Keywords: Nuclear factor erythroid-2-related factor 2 (Nrf2); Acetaminophen (APAP); Acute liver injury; Oxidative stress; Ginsenoside Rg1; ALT; alanine transaminase; ARE; antioxidant element; AST; aspartate transaminase; CAT; catalase; GCL; glutamate-cysteine ligas

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysis

Keywords: LUSC; lung squamous cell cancer; TCGA; the Cancer Genome Atlas; GTEx; genotype-tissue expression; UGT1A1; UDP glucuronosyltransferase family 1 member A1; UGT1A3; UDP glucuronosyltransferase family 1 member A3 UGT1A6 UDP glucuronosyltransferase family 1 me

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells

Keywords: Cycloicaritin; UGT1A1; Glucuronidation; HeLa cells; Efflux transporters;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical and pharmacogenetic determinants of 5-fluorouracyl/leucovorin/irinotecan toxicity: Results of the PETACC-3 trial

Keywords: Colon cancer; Toxicity; UGT1A1; FOLFIRI;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Recomendaciones de GESIDA/PETHEMA sobre el diagnóstico y tratamiento de los linfomas en pacientes infectados por el virus de la inmunodeficiencia humana

Keywords: Linfoma no hodgkiniano; Linfoma de Hodgkin; VIH; Sida; Tratamiento antirretroviral; Non-Hodgkin's lymphoma; Hodgkin's lymphoma; HIV; AIDS; Antiretroviral therapy; ABC; abacavir; ABVD; adriamicina, bleomicina, vinblastina y dacarbazina; Ara-C; arabinósido

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

GESIDA/PETHEMA recommendations on the diagnosis and treatment of lymphomas in patients infected by the human immunodeficiency virus

Keywords: ABC; abacavir; ABVD; adriamycin, bleomycin, vinblastine and dacarbazine; Ara-C; cytosine arabinoside; AZT; zidovudine; BCNU; carmustine; BEACOPP; bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine and prednisone; CDC; Centers fo

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

A Multicenter Clinical Phase II Study of FOLFOXIRI Plus Bevacizumab as First-line Therapy in Patients With Metastatic Colorectal Cancer: QUATTRO Study

Keywords: Bevacizumab; Colorectal cancer; FOLFOXIRI; UGT1A1;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice

Keywords: 3-NT; 3-nitro-tyrosine; ALI; acute liver injury; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CAT; catalase; Cl-Cas-3; cleavage Caspase-3; CYP2E1; cytochrome P450 2E1; ERK1/2; extracellular signal-regulated kinase 1

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Digital gene-expression profiling analysis of the fatty liver of Landes geese fed different supplemental oils

Keywords: ABCA1; ATP-binding cassette, sub-family A, member 1; ABCB4; ATP-binding cassette, sub-family B, member 4; ABCC2; ATP-binding cassette, sub-family C, member 2; ABCG5; ATP-binding cassette, sub-family G, member 5; ABCG8; ATP-binding cassette, sub-family G,

دانلود رایگان متن کامل مقاله ISI 63 صفحه سال انتشار : 2018 سفارش ترجمه

Comparison of the inhibition potentials of icotinib and erlotinib against human UDP-glucuronosyltransferase 1A1

Keywords: Icotinib; Erlotinib; UGT1A1; Inhibitory effects; Drug-drug interactions (DDIs);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of UDP-glucuronosyltransferase (UGT) polymorphisms on the pharmacokinetics of febuxostat in healthy Chinese volunteers

Keywords: Febuxostat; Pharmacokinetics; Polymorphisms; UGT1A1; UGT1A3;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacogénétique des médicaments anticancéreux : état des connaissances et des pratiques - recommandations du Réseau national de pharmacogénétique (RNPGx)

Keywords: Pharmacogénétique; DPD; UGT1A1; TPMT; Anticancéreux; Oncologie;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Impact of chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) on cancer treatment outcomes: An overview about well-established and recently emerging clinical data

Keywords: ABCC1/MRP; ATP binding cassette subfamily C member 1/ multidrug resistance protein; ABVD; doxorubicine-bleomycin-vinblastine-dacarbazine; AC; doxorubicin-cyclophosphamide; ANC; absolute neutrophil count; ASCO; American Society of Clinical Oncology; AUC; a

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case

Keywords: Cyclosporin (PubChem CID: 122172945); Atazanavir (PubChem CID: 86601659); Nelfinavir (PubChem CID: 122130496); Itraconazole (PubChem CID: 86611782); Amphotericin B (PubChem CID: 122130047); Ciprofloxacin (PubChem CID: 92135222); Clopidogrel (PubChem CID:

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacogenetics of anti-cancer drugs: State of the art and implementation - recommendations of the French National Network of Pharmacogenetics

Keywords: Pharmacogenetics; DPD; UGT1A1; TPMT; Cancer; Oncology;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

UGT genotyping in belinostat dosing

Keywords: Belinostat; UGT1A1; Polymorphisms; Pharmacogenomics; Pharmacokinetics; Pharmacodynamics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction

Keywords: Human induced pluripotent stem cells; Hepatocyte; Drug metabolism; ATF5; c/EBPα; PROX1; Human iPS-HLCs; Human induced pluripotent stem cells-derived hepatocyte-like cells; HLCs; Hepatocyte-like cells; ATF5; Activating transcription factor 5; c/EBPα; CCA

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Apport de la pharmacogénétique à la pharmacovigilance

Keywords: Pharmacogénétique; Pharmacovigilance; Effets indésirables médicamenteux; UGT1A1; TPMT; DPYD; CYP2D6; VKORC1/CYP2C9; CYP2C19; HLA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Comparison of mercury sulfides with mercury chloride and methylmercury on hepatic P450, phase-2 and transporter gene expression in mice

Keywords: P450; cytochrome enzyme genes; Ugt1a1; UDP-glucuronosyltransferase family 1, subfamily A, polypeptide 1; Sult1a1; sulfotransferase family 1, subfamily a, peptide1; Gst-mu; glutathione S-transferase mu; Oatp1a1; organic anion transporting polypeptide 1a1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Polymorphisms in UGT1A1 Gene Predispose South Indians to Pigmentous Gallstones

Keywords: GSD; gallstone disease; ABCG; 8 ATP-binding cassette, sub-family G (WHITE), member 8; SNPs; single nucleotide polymorphisms; UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1); ABCG6; ATP-binding cassette protein subfamily G, member 6;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

Keywords: FLU; flutamide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC; 3-methylcholanthrene; ABCC4; ATP-binding cassette sub-family C member 4; MRP4; mul

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice

Keywords: ABC; ATP-binding cassette; AUC; area under the concentration-time curve; DDI; drug-drug interactions; E2G; estradiol 17β-d-glucuronide; i.v.; intravenous; OATP; organic anion-transporting polypeptide; TKI; tyrosine kinase inhibitor; UGT1A1; UDP-glucuro

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Determination of deferasirox in human plasma by short-end injection and sweeping with a field-amplified sample stacking and micellar electrokinetic chromatography

Keywords: BGE; background electrolyte; CE; capillary electrophoresis; DFX; deferasirox; EOF; electroosmotic flow; FASS; field-amplified sample stacking; HPLC; high-performance liquid chromatography; LOD; limit of detection; LOQ; limit of quantitation; MEKC; micella

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms

Keywords: Akt PKB; protein kinase B; APAP; acetaminophen; ALT; alanine aminotransferase; ARE; antioxidant response element; β-Trcp; beta-transducin repeat containing protein; CDDO-Im; 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; Cul3; cullin-3; DMSO;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

Correlation between UGT1A1 polymorphisms and raltegravir plasma trough concentrations in Japanese HIV-1-infected patients

Keywords: HIV-1; Polymorphisms; Raltegravir; UGT1A1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice

Keywords: Obesity; Ugt1a1; SN-38; Irinotecan; Colorectal cancer; Chemotherapy; Pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research paperHigh resolution melting analysis of the NR1I3 genetic variants: Is there an association with neonatal hyperbilirubinemia?

Keywords: CAR; constitutive androstane receptor; NR1I3; nuclear receptor subfamily 1, group I, member 3; HRM; high resolution melting; UGT1A1; uridine diphosphate glucuronosyltransferase 1A1; gtPBREM; glucuronosyltransferase phenobarbital-responsive enhancer module

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

UDP-glucuronosyltransferase (UGT) 1A1 mainly contributes to the glucuronidation of trovafloxacin

Keywords: Trovafloxacin; UDP-Glucuronosyltransferase; UGT1A1; Acyl-glucuronide; HepatotoxicityUGT, UDP-glucuronosyltransferase; HPLC, high performance liquid chromatography; AIC, Akaike's information criterion

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: Identification of UGT1A1 and UGT1A8 as the major contributing enzymes

Keywords: Bavachinin; UDP-glucuronosyltransferases; UGT1A1; UGT1A8; Glucuronidation; Human tissues

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Tranilast: A review of its therapeutic applications

Keywords: ARH; aryl hydrocarbon receptor; bFGF; basic fibroblast growth factor; cAMP; cyclic AMP; CDK; cyclin-dependent kinase; COX-2; cyclooxsygenase-2; CTGF; connective tissue growth factor; CXCL; CX chemokine ligand; CXCR; CX chemokine receptor; EMT; epithelial-

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Preparation of reference material for UGT1A1 (TA)n polymorphism genotyping

Keywords: UGT1A1; Reference material; Cloning; Sequencing; Fragment analysis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Regulation and expression of aberrant methylation on irinotecan metabolic genes CES2, UGT1A1 and GUSB in the in-vitro cultured colorectal cancer cells

Keywords: Colorectal cancer cell; Aberrant methylation; CES2; UGT1A1; GUSB; CPT-11; Gene expression

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleGenetic variation underlying common hereditary hyperbilirubinaemia (Gilbert's syndrome) and respiratory health in the 1946 British birth cohort

Keywords: UGT1A1; uridine diphosphate glucuronosyltransferase polypeptide 1A1; TA; thymine-adenine; FEV1; forced expiratory volume in 1 second; FVC; forced vital capacity; ROS; reactive oxygen species; MRC; Medical Research Council; NSHD; National Survey of Health

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities

Keywords: UGT; uridine 5′-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase); CYP; cytochrome P450; UPLC; ultra performance liquid chromatography; MRM; multiple reaction monitoring; DP; declustering potential; CE; collision energy; CXP; collision cel

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Pregnane X receptor-mediated transcriptional activation of UDP-glucuronosyltransferase 1A1 by natural constituents from foods and herbs

Keywords: Natural constituents; PXR; Induction; UGT1A1;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

Activation of human biliverdin-IXα reductase by urea: Generation of kinetically distinct forms during the unfolding pathway

Keywords: hBVR-A; human biliverdin-IXα reductase; PQQ; pyrroloquinoline quinone; UGT1A1; bilirubin UDP-glucuronosyltransferase 1; Mrp2; multidrug resistance protein 2; HO-1; haem oxygenase 1; ROS; reactive oxygen species; QM/MM; quantum mechanics/molecular-mechani

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The concentration of cell-free DNA in focal epilepsy

Keywords: AED; antiepileptic drug; CD; celiac disease; cf-DNA; cell-free DNA; CNS; central nervous system; FLE; frontal lobe epilepsy; HS; hippocampal sclerosis; IL; interleukin; IL1-RA; interleukin 1 receptor antagonist; iNOS; inducible nitric oxide synthase; MRI;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Consumption of baby kale increased cytochrome P450 1A2 (CYP1A2) activity and influenced bilirubin metabolism in a randomized clinical trial

Keywords: BHNRC; Beltsville Human Nutrition Research Center; CYP1A2; cytochrome P450 family 1 subfamily A member 2; CYP2A6; cytochrome P450 family 2 subfamily A member 6; CV; control vegetables; GST; glutathione S-transferase; GSTA; glutathione S-transferase alpha;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2020 سفارش ترجمه

A clinical PCR fragment analysis assay for TA repeat sizing in the UGT1A1 promoter region

Keywords: UGT1A1; Pharmacogenetics; Irinotecan; Gilberts syndrome; Polymorphism

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Promoter length polymorphism in UGT1A1 and the risk of sporadic colorectal cancer

Keywords: UGT1A1; polymorphism; colorectal cancer; risk

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه