Keywords: Inflammation; Leukocyte; Non-communicable diseases; Receptor; Renin-angiotensin system; ABI; ankle-brachial index; ACE; angiotensin-converting enzyme; ATRAP; angiotensin II type 1 receptor-associated protein; AT1R; angiotensin II type 1 receptor; BM-KO; b
مقالات ISI (ترجمه نشده)
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Keywords: Ach; acetylcholine; ARE; antioxidant response element; BH4; Tetrahydrobiopterin; DMNQ; 2,3-Dimethoxy-1,4-naphthoquinone; EDRF; Endothelium-derived relaxing factor; eNOS; Endothelial nitric-oxide synthase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; G
Keywords: AGT; alanine-glyoxylate aminotransferase; AKI; acute kidney injury; CKD; chronic kidney diseases; cGN; crescentic glomerulonephritis; DAMPs; danger associated molecular patterns; DCs; dendritic cells; ECM; extracellular matrix; ESRD; end stage renal disea
Keywords: Chronic kidney disease; Renal fibrosis; Natural products; Traditional Chinese medicine; TGF-β/Smad; ACE; angiotensin-converting enzyme; AGT; angiotensinogen; AR; alismatis rhizoma; AT1R; angiotensin II type 1 receptor; AAN; aristolochic acid nephropathy
Keywords: AKI; acute kidney injury; α-SMA; αâsmooth muscle actin; CKD; chronic kidney disease; ECM; extracellular matrix; CTGF; (connective tissue growth factor); DC; dendritic cells; DTR; diphtheria toxin receptor; EGF; epidermal growth factor; EMT; epithelial
Keywords: Baicalin; Baicalein; Flavonoids; Chemoprevention; Inflammatory diseases; 6-OHDA; 6-hydroxydopamine; 12-LOX; 12-lipoxygenase; AIDS; acquired immunodeficiency disorder syndrome; AhR; aryl hydrocarbon receptor; AIH; autoimmune hepatitis; AICAR; 5-aminoimidaz
Keywords: HE; hematoxylin-eosin; SOC; sham-operated control; UUO; unilateral ureteral obstruction; NOK; contralateral non-obstructed kidney; OK; obstructed kidney; PAS; periodic acid-Schiff; ANOVA; analysis of variance; ppm; parts per million; TGF-β1; transforming
Keywords: autofluorescence; collagen; fibrosis; FLIM; SHG; UUO;
Keywords: Rutin; UUO; Tubulointerstitial fibrosis; Inflammation
Keywords: Syk; Renal fibrosis; Fibroblast; Macrophage; Immunohistochemistry; UUO
Keywords: α-SMA; α-smooth muscle actin; ALK1; activin receptor-like kinase 1; ALK5; activin receptor-like kinase 5; ANOVA; analysis of variance; ECM; extracellular matrix; Eng; endoglin; ICAM-1; intercellular cell adhesion molecule-1; NO; non-obstructed; O; obstr
Keywords: kidney; fibrosis; ureteral obstruction; stachydrine; caspases; BUN; blood urea nitrogen; RIF; renal interstitial fibrosis; Scr; serum creatinine; UUO; unilateral ureteral obstruction;
Keywords: Decorin; Lumican; Fibromodulin; Toll-like receptor; Matrix metalloproteinases; 5/6-Nx; 5/6-nephrectomized Sprague-Dawley rats; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ALK; activin like kinase; ATS; hymocyte serum; BGN (Bgn)
Keywords: Chitobionic acid; Polysorbitol gene transporter; HGF; Kidney targeting; UUO
Suppression of Elp2 prevents renal fibrosis and inflammation induced by unilateral ureter obstruction (UUO) via inactivating Stat3-regulated TGF-β1 and NF-κB pathways
Keywords: Renal fibrosis and inflammation; UUO; Elp2; STAT3; TGF-β1;
Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy
Keywords: ACR; albumin-to-creatinine ratio; AUC0-t; area under the curve; BuOH; n-butanol; BUN; blood urea nitrogen; Cmax; peak concentration; C13-NMR; C13-nuclear magnetic resonance; CCr; creatinine clearance rate; CCR2; CCchemkin receptor 2; CDCl3; Deuterotrichlo
Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy
Keywords: legumain; M2 macrophage; renal interstitial fibrosis; UUO;
Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment
Keywords: ACE2; angiotensin-converting enzyme-2; AGE; advanced glycation end-product; AT1R; angiotensin type 1 receptor; BMP; bone morphogenetic proteins; BMP-7; bone morphogenetic protein 7; CKD; chronic kidney diseases; Co-Smads; common mediator Smads; ECM; extra
Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells
Keywords: apoptosis; cisplatin; DNA damage; L3MBTL2; p53; UUO;
The glucagon-like peptide-1 (GLP-1) analog liraglutide attenuates renal fibrosis
Keywords: CKD; chronic kidney disease; ESRD; end-stage renal disease; UUO; unilateral ureteral obstruction; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; GLP-1; glucagon-like peptide-1; GLP-1R; glucagon-like peptide-1 receptor; TGF-β1; transfo
The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery
Keywords: ADAMs; a disintegrin and metalloproteinases; ADAMTS; ADAMs with thrombospondin motifs; BALF; bronchoalveolar lavage fluid; BAPN; β-aminopropionitrile; CD; Crohn's disease; ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; EndoMT; endo
Hydrogen sulfide-producing cystathionine γ-lyase is critical in the progression of kidney fibrosis
Keywords: CSE; Cystathionine γ-lyase; H2S; Hydrogen sulfide; GSH; Glutathione; CKD; Chronic kidney disease; UUO; Unilateral ureteral obstruction; P5P; Pyridoxal-5â²-phosphate; CBS; Cystathionine β-synthase; 3-MST; 3-mercaptopyruvate sulfurtransferase; Nrf2; NFâ
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho
Keywords: BTP2; fibrosis; klotho; TRPC6; TRPC3; UUO;
Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice
Keywords: SP-A; surfactant protein A; UUO; unilateral ureter obstruction; HMGB1; high mobility group box 1; TGF-β; transforming growth factor β; BMM; bone marrow derived-macrophages; HPTC; human proximal tubular cell; qRT-PCR; Reverse transcription and quantitati
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis
Keywords: CKD; chronic kidney disease; UUO; unilateral ureteral occlusion; TGFβ; transforming growth factor-beta; DNMT; DNA methyltransferase; MTD; myofibroblast trans-differentiation; MSP; methylation-specific PCR; BSP; bisulfite-sequencing PCR; Renal fibrosis; K
Carnosic acid attenuates unilateral ureteral obstruction-induced kidney fibrosis via inhibition of Akt-mediated Nox4 expression
Keywords: TGF-β; transforming growth factor-β; CA; carnosic acid; α-SMA; α-smooth muscle actin; COLI; collagen I; FN; fibronectin; PAI-1; plasminogen activator inhibitor-1; Nox4; NADPH oxidase 4; ROS; reactive oxygen species; Nrf2; nuclear factor erythroid-2 re
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis
Keywords: AT-1; angiotensin II type 1 receptor; VSMC; vascular smooth muscle cell; TGF-β1; transforming growth factor-β1; Ang-II; angiotensin II; ECM; extracellular matrix; CKD; chronic kidney disease; eNOS; endothelial nitric oxide synthase; UUO; unilateral uret
Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy
Keywords: CKD; Chronic kidney disease; CRF; Chronic renal failure; RA; Rheumatoid arthritis; ON; Obstructive nephropathy; ROS; Reactive oxygen species; UUO; Unilateral ureteral obstruction; HE; Hematoxylin and eosin; SIN; Sinomenine; LPS; Lipopolysaccharide; 3-MA;
GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy
Keywords: ureteral obstruction; epithelial-mesenchymal transition; hydrogen sulfide; transforming growth factors; angiotensin II; ANGIIR1; ANGII receptor type 1; Col1α1; collagen 1α; EMT; epithelial-mesenchymal transition; FOV; field of view; GAPDH; glyceraldehyd
Cell Type Specific Changes in BMP-7 Expression Contribute to the Progression of Kidney Disease in Patients with Obstructive Uropathy
Keywords: kidney; ureteral obstruction; fibrosis; bone morphogenetic protein 7; growth and development; AQP; aquaporin; BMP-7; bone morphogenic protein-7; THP; Tamm-Horsfall protein; UPJ; ureteropelvic junction; UUO; unilateral ureteral obstruction;
TGF-β/BMP proteins as therapeutic targets in renal fibrosis. Where have we arrived after 25 years of trials and tribulations?
Keywords: Kidney fibrosis; Smad proteins; TGF-β1; Bone morphogenetic proteins; Inhibitors; micro-RNAs; ALK1-6; activin receptor-like kinase 1-6; BAMBI; BMP and activin receptor membrane bound inhibitor; BMP; bone morphogenetic protein; CKD; chronic kidney disease;
The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation
Keywords: Kidney fibrosis; Epithelial-to-mesenchymal transition; Fibroblast; Notch; TGF-β; DBZ; dibenzazepine; UUO; unilateral ureteral obstruction; NICD; Notch intracellular domain; ICN; intracellular domain of Notch; TECs; tubular epithelial cells; ECM; extracel
R-268712, an orally active transforming growth factor-β type I receptor inhibitor, prevents glomerular sclerosis in a Thy1 nephritis model
Keywords: ALK-5 inhibitor; Glomerulonephritis; Fibrosis; TGF-β; UUO
Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity
Keywords: TGF-β1; transforming growth factor-β1; PAI-1; plasminogen activator inhibitor-1; ROS; reactive oxygen species; MEFs; mouse embryo fibroblasts; HPTEC; human proximal tubular epithelial cells; DMEM; Dulbecco's modified Eagle's Medium; DPI; diphenyleneiodo
Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction
Keywords: JAK; STAT; SOCS; Renal fibrosis; MMP-2; UUO
Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy
Keywords: CD44; HGF; TGF; UUO; Wnt/β-catenin;
Wnt signaling in liver fibrosis: Progress, challenges and potential directions
Keywords: Liver fibrosis; Wnt signaling; Canonical Wnt signaling pathway; Hepatic stellate cell; Myofibroblastic transdifferentiation; HSCs; hepatic stellate cells; GFAP; glial fibrillary acidic protein; a-SMA; a-smooth muscle actin; TRAIL; tumor necrosis factor-re
Urological Complications and Vesicoureteral Reflux Following Pediatric Kidney Transplantation
Keywords: kidney transplantation; postoperative complications; urology; vesico-ureteral reflux; ESRD; end-stage renal disease; GU; genitourinary; MAG3; mercaptoacetyltriglycine; PUV; posterior urethral valves; RTX; renal transplantation; UNC; ureteroneocystostomy;
Protective role of the vitamin D receptor
Keywords: VDR; vitamin D receptor; RAS; renin-angiotensin system; VDRA; vitamin D receptor agonists; VDRE; vitamin D response elements; RXR; retinoid X receptors; SRC; steroid receptor activator complex; DRIP; vitamin D receptor interacting protein complex; NCoR; n
Imatinib-ULS-lysozyme: A proximal tubular cell-targeted conjugate of imatinib for the treatment of renal diseases
Keywords: Kidney; Imatinib; Platinum linker; Lysozyme; UUO; Drug delivery
Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats
Keywords: IMPDH; BMS-566419; MMF; UUO; Renal fibrosis; Collagen; MCP-1; TGF-β1
Effect of beraprost sodium (BPS) in a new rat partial unilateral ureteral obstruction model
Keywords: PGI2; Beraprost sodium; Unilateral ureteral obstruction; UUO; Tubulointerstitial fibrosis
Transcriptional regulation of NF-κB by ring type decoy oligodeoxynucleotide in an animal model of nephropathy
Keywords: Transcription factor; NF-κB; TGF-β1; Fibrosis; Nepropathy; UUO
Atorvastatin Ameliorates Tubulointerstitial Fibrosis and Protects Renal Function in Chronic Partial Ureteral Obstruction Cases
Keywords: kidney; ureteral obstruction; nephrectomy; atorvastatin; fibrosis; α-SMA; α-smooth muscle actin; BW; body weight; GFR; glomerular filtration rate; PE; polyethylene; PUO; partial ureteral obstruction; TBS; tris-buffered saline; TGF-β; transforming growt
Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction
Keywords: fibrosis; Hgf; Met receptor; proliferation; repair; UUO
Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction
Keywords: kidney; fibrosis; EMT; UUO; stretch
Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation
Keywords: renal fibrosis; UUO; reimplantation; inflammation
TNF-α deficiency accelerates renal tubular interstitial fibrosis in the late stage of ureteral obstruction
Keywords: TNF-α; TGF-β1; Renal fibrosis; UUO; TNF-α receptors; EMT; Macrophage
IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
Keywords: IN-1130; ALK5; TGF-β; Renal fibrosis; UUO
Differential immunoexpressions of cytoskeletons in renal epithelial and interstitial cells in rat and canine fibrotic kidneys, and in kidney-related cell lines under fibrogenic stimuli
Keywords: Epithelial-mesenchymal transition; Extracellular matrix; Growth factor; Kidney-related cell line; Renal myofibroblast; α-SMA; α-smooth muscle actin; BMP-7; bone morphogenic protein-7; CDDP; cisplatin; ECM; extracellular matrix; EGF; epidermal growth fac