Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists
Keywords: VLA-4; Integrin; Oral availability
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Pyridone derivatives as potent and selective VLA-4 integrin antagonists
Keywords: VLA-4; Molecular overlays; Pharmacophore; Pyridone; Ureas; GASP
Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists
Keywords: VLA-4; Integrin; Pyridone; Bioavailability
NOS2 regulates cytokine production and VLA-4 expression in experimental autoimmune encephalomyelitis
Keywords: Nitric oxide; Experimental autoimmune encephalomyelitis; Immune regulation; VLA-4; Interferon gamma; Tumor necrosis factor-alpha
Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent
Keywords: Integrin; Antagonist; VLA-4
2,3-Diphenylpropionic acids as potent VLA-4 antagonists
Keywords: VLA-4; VCAM-1; 2,3-Diphenylpropionic acid;
Identified a morpholinyl-4-piperidinylacetic acid derivative as a potent oral active VLA-4 antagonist
Keywords: VLA-4; Integrin; Asthma;
Effects of the very late adhesion molecule 4 antagonist WAY103 on human peripheral blood eosinophil vascular cell adhesion molecule 1-dependent functions
Keywords: Eosinophil; very late adhesion molecule 4 antagonists; degranulation; respiratory burst; adhesion; transendothelial migration; vascular cell adhesion molecule 1; endothelial cells; EDN; Eosinophil-derived neurotoxin (RNase 2); HBSS/gel; HBSS with 0.1% gel
2004 Pathogenesis of Rare Neuroimmunologic Disorders, Hyatt Regency Inner Harbor, Baltimore, MD, August 19th 2004-August 20th 2004
Keywords: ADEM; Acute disseminated encephalomyelitis; AchR; Acetylcholine receptor; ALD; Adrenoleukodystrophy; ALDP; Protein encoded by X-ALD gene ABCD1; AMAN; Acute motor axonal neuropathy; APC; Antigen presenting cell; APL; Altered peptide ligand; C. jejuni; Camp
Aza-bicyclic amino acid carboxamides as α4β1/α4β7 integrin receptor antagonists
Keywords: α4β1 integrin; α4β7 integrin; VLA-4; VCAM-1; MAdCAM-1; Crohn’s disease; Inflammatory bowel disease; Asthma; Multiple sclerosis; Rheumatoid arthritis; N-Acylphenylalanine; Azabicyclo[2.2.2]octane; Leukocytosis
Involvement of α4 integrins in maintenance of cardiac sympathetic axons
Keywords: Sympathetic; Integrins; Alpha-4; Beta-1; VLA-4; Myocardial infarction; Sprouting; Neurite outgrowth; Reinnervation; Axon; Synapse; Hypertensive;
Association between Pterostilbene and Quercetin Inhibits Metastatic Activity of B16 Melanoma
Keywords: Polyphenols; pterostilbene; quercetin; melanoma; metastases; B16M-F10; B16 melanoma F10; RESV; resveratrol; t-RESV; trans-resveratrol; PTER; pterostilbene; t-PTER; trans-pterostilbene; QUER; quercetin; HSE; hepatic sinusoidal endothelium; VCAM-1; vascular
PDE4 inhibitors as new anti-inflammatory drugs: Effects on cell trafficking and cell adhesion molecules expression
Keywords: BAL; bronchoalveolar lavage; CAM; cell adhesion molecule; cAMP; cylic adenosine monophosphate (AMP); cGMP; cyclic guanosine 5C-monophosphate (GMP); CINC/KC; cytokine-induced neutrophil chemoattractant/keratinocyte-derived chemokine; COPD; chronic obstruct