Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists

A series of pyridone-N-benzyl-propanoic acids have been optimised to afford potent orally bioavailable VLA-4 antagonists.

Systematic optimisation of a previously described series of novel VLA-4 antagonists has identified a potent orally bioavailable VLA-4 integrin antagonist.Figure optionsDownload as PowerPoint slide