Keywords: GnRH neurons; Kisspeptin neurons; Female puberty; Chromatin modifications; DNA methylation; Transcriptional repression; Transcriptional activation; Epigenetic regulators; microRNAs; Long noncoding RNAs; 5hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosin
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Top surface blade residues and the central channel water molecules are conserved in every repeat of the integrin-like β-propeller structures
Keywords: PDB; Protein Data Bank; Vgb; virginiamycin B lyase; WDR5; WD repeat-containing protein 5; Protein; Structure; Beta-propeller; Repeat; Surface; Water;
Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5
Keywords: WDR5; Biotin; Small-molecule probe; Molecular docking; Chemoprecipitation;
WDR5 positively regulates p53 stability by inhibiting p53 ubiquitination
Keywords: WDR5; p53; Ubiquitination; A549Â cells;
Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing
Keywords: MSC; Mesenchymal stromal/stem cell; AMSC; Adipose-tissue derived mesenchymal stromal/stem cell; RT-qPCR; Real-time reverse transcriptase quantitative polymerase chain reaction; RNA-seq; RNA sequencing; EpiReg; Epigenetic regulator; HAT; Histone acetyl tra
Regulation of protein kinase C-related kinase (PRK) signalling by the TPα and TPβ isoforms of the human thromboxane A2 receptor: Implications for thromboxane- and androgen- dependent neoplastic and epigenetic responses in prostate cancer
Keywords: ADT; androgen deprivation therapy; AR; androgen receptor; ARE; androgen response element; AA; arachidonic acid; BCR; biochemical recurrence; ChIP; chromatin immunoprecipitation; COX; cyclooxygenase/prostaglandin G2/H2 synathase; CRPC; castrate resistant p
The MLL/Setd1b methyltransferase is required for the Spemann's organizer gene activation in Xenopus
Keywords: Wdr5; Setd1b; Wnt/β-catenin signaling; Organizer formation; H3K4 trimethylation; Xenopus
Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria
Keywords: AMBRA1; autophagy/beclin 1 regulator 1; ATG; autophagy-related proteins; Bcl-2; B-cell lymphoma 2; BECN1; Beclin 1, autophagy-related; Bif-1; bax-interacting factor-1; BLAST; Basic Local Alignment Search Tool; BLAT; BLAST Like Alignment Tool; cDNA; comple
Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2
Keywords: HSF2; WDR5; Set1/MLL complex; Histone; Trimethylation; Acetylation;
Research ArticleMyocardin related transcription factor A programs epigenetic activation of hepatic stellate cells
Keywords: HSC; hepatic stellate cell; MRTF-A; myocardin related transcription factor A; ASH2; absent, small, or homeotic discs 2; WDR5; WD domain repeat 5; SMA; smooth muscle actin; shRNA; short hairpin RNA; Hepatic stellate cell; Liver fibrosis; Transcriptional re
A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy
Keywords: Ang II; angiotensin II; Ash2; absent, small, or homeotic discs 2; Brg1; Brahma-related gene 1; COMPASS; complex proteins associated with SET1; ET-1; endothelin; HMT; histone methyltransferase; MRTF-A; myocardin-related transcription factor A; Wdr5; WD dom
A2b adenosine signaling represses CIITA transcription via an epigenetic mechanism in vascular smooth muscle cells
Keywords: CIITA; class II transactivator; GCN5; general control of amino acid synthesis protein 5; PCAF; p300-and-CBP-associated factor; STAT1; signal transducer and activator of transcription 1; VSMC; vascular smooth muscle cell; WDR5; WD repeat-containing protein
Using Lamm-Equation modeling of sedimentation velocity data to determine the kinetic and thermodynamic properties of macromolecular interactions
Keywords: Arp2/3; actin related protein 2-actin related protein 3 complex; AUC; analytical ultracentrifugation; LE; Lamm Equation; LEq; Lamm Equation coupled to kinetic reaction fluxes q; MSSV; multisignal sedimentation velocity; OD; optical density; SE; sediment
Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiation
Keywords: Wdr5; FGF18; Twist-1; Chondrogenesis
The 19S proteasome positively regulates histone methylation at cytokine inducible genes
Keywords: Sug1; 26S proteasome; Transcriptional regulation; Epigenetic; Compass; WDR5
Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development
Keywords: Wdr5; BIG-3; Endochondral bone formation; Wnt signaling; Osteoblasts; Differentiation; Osteoprotegerin