Keywords: Cytokines; hard tissue formation; human dental pulp cells; lipopolysaccharide; Wnt5a;
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Keywords: Wnt; wingless-type MMTV integration site family; β-catenin; beta-catenin; Dkk1; dickkopf-related protein 1; sFRP4; secreted frizzled-related protein 4; PR; progesterone receptor; ERα; estrogen receptor alpha; Hoxa10; Homeobox A10; COUP-TFII; COUP transc
Keywords: Lymphangioma; Lymphatic malformation; Gorham–Stout disease; Lymphangiectasia; Wnt5A; VEGF-C
Keywords: APP; amyloid precursor protein; APLP; amyloid precursor like protein; APBA1; precursor protein binding, family A; Arc; member 1, activity-regulated cytoskeleton-associated protein; ApoeR2; apolipoprotein E receptor 2; CR; Cajal-Retzius; CASK; calcium/calm
Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis
Keywords: Wnt5a; Box5; Atherosclerosis; Foam cell; CD36;
Impaired Wnt5a signaling in extravillous trophoblasts: Relevance to poor placentation in early gestation and subsequent preeclampsia
Keywords: Early placentation; Extravillous trophoblast; Preeclampsia; Spiral artery remodeling; Wnt5a;
Regulation of osteogenesis by micro/nano hierarchical titanium surfaces through a Rock-Wnt5a feedback loop
Keywords: Titanium; Micro/nano topography; ROCK; Wnt5a; Osteogenic differentiation;
Sonic hedgehog regulates the pathfinding of descending serotonergic axons in hindbrain in collaboration with Wnt5a and secreted frizzled-related protein 1
Keywords: Shh; Sonic Hedgehog; Sfrp1; Secreted frizzled-related protein 1; PCP; planar cell polarity; 5-HT; 5-hydroxytryptamine; E10.5; Embryonic day 10.5; A-P; Anterior to posterior; Fzd3; Frizzled 3; DMSO; Dimethylsulfoxide; Ptch1; Patched 1; Smo; Smoothened; R4;
Vangl2 is essential for myocardial remodeling activated by Wnt/JNK signaling
Keywords: Wnt5a; JNK; Van-Gogh-like-2; Myocardial remodeling;
Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis
Keywords: Keratitis; Aspergillus fumigatus; Wnt5a; Inflammation; Signaling pathway;
Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-α/NF-κB-Wnt5a negative-feedback loop
Keywords: Wnt5a; TNF-α; Intervertebral disc degeneration; Nucleus pulposus; Negative feedback loop;
Egr-1 transactivates WNT5A gene expression to inhibit glucose-induced β-cell proliferation
Keywords: β-cell; Wnt5a; Egr-1; Glucolipotoxicity; Lipotoxicity; Saturated fatty acids;
Suppression of Wnt5a, but not Wnts, relieves chronic post-thoracotomy pain via anti-inflammatory modulation in rats
Keywords: Wnt5a; Wnts; TLR4; Chronic post-thoracotomy pain; Inflammation; CPTP; chronic post-thoracotomy pain; SDH; spinal cord dorsal horn; DRG; dorsal root ganglion; MWT; mechanical withdrawal threshold; QHP; qualitative hyperalgesia profile; POD; postoperative d
Wnt5a and its signaling pathway in angiogenesis
Keywords: Wnt5a; Angiogenesis; Signaling pathway;
Hydronephrosis in the Wnt5a-ablated kidney is caused by an abnormal ureter-bladder connection
Keywords: MM; metanephric mesenchyme; ND; nephric duct; PCP; planar cell polarity; UB; ureteric buds; UPJO; ureteropelvic junction obstruction; UVJO; ureterovesical junction obstruction; Wnt5a; Kidney development; Hydronephrosis; Nephric duct; Metanephric mesenchym
Critical roles of Wnt5a-Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ÎNp63β-mediated epithelial-mesenchymal transition
Keywords: DMEM; Dulbecco's modified Eagle medium; EMT; epithelial-to-mesenchymal transition; LEF; lymphoid enhancer factor; LI; labeling index; MMP; matrix metalloproteinase; OSCC; oral squamous cell carcinoma; RT; reverse transcription; TCF; T-cell factor; Wnt5a
Original ArticleRSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway
Keywords: RSPO2; Colorectal cancer; Metastasis; Fzd7; Wnt5a; RSPO2; R-spondin 2; CRC; colorectal cancer; RSPO; R-spondins; TSR-1; thrombospondin type 1 repeat; LGRs; leucine-rich repeat-containing G-protein-coupled receptors; Wnt/PCP; Wnt/planar cell polarity; MAPK
Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways
Keywords: Age; airway remodeling; airway inflammation; allergy; asthma; bronchial epithelial cells; house dust mite; leukotrienes; lipid mediators; nasal polyps; secretory phospholipase A2; transglutaminase 2; Wnt5a; AEC; Airway epithelial cell; ASMC; Airway smooth
The secreted protein WNT5A regulates condylar chondrocyte proliferation, hypertrophy and migration
Keywords: Temporomandibular joint; Condylar cartilage; Chondrocyte proliferation; Chondrocyte hypertrophy; Chondrocyte migration; WNT5A;
Can Wnt5a and Wnt non-canonical pathways really mediate adipocyte de-differentiation in a tumour microenvironment?
Keywords: Cancer; Pancreas; Wnt5a; Beta-catenin pathway; De-dedifferentiation; Adipocyte;
Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring
Keywords: DBP; di-n-butyl phthalate; EEDs; environmental endocrine disrupting compounds; ARMs; anorectal malformations; ARMs & hypospadias; anorectal malformations in combination with hypospadias; PND; postnatal day; Shh; sonic hedgehog; Bmp4; bone morphogenetic pr
Spatial regulation of cell cohesion by Wnt5a during second heart field progenitor deployment
Keywords: Wnt5a; Planar cell polarity; Second heart field; Outflow tract; Morphogenesis; Heart development; Cell adhesion;
Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse
Keywords: Primordial germ cell; PGC; Msx1, Msx2; Bmp pathway; Wnt5a; PGC migration; Fibronectin;
Dual mechanisms of action of the RNA-binding protein human antigen R explains its regulatory effect on melanoma cell migration
Keywords: AREs; Adenylate uridylate rich elements; HOPP; Heuristic online phenotype prediction; MMP-9; Matrix metalloproteinase-9; RBP; RNA binding protein; RIP; RNA binding protein immunoprecipitation; WNT5A; Wingless-type MMTV integration site family 5A;
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation
Keywords: BRAF; v-Raf murine sarcoma viral oncogene homolog B; MAPK; mitogen-activated protein kinases; MMP; matrix metalloproteinase; ECM; extracellular matrix; IL-8; interleukin 8; EGFR; epidermal growth factor receptor; TIMP-2; metallopeptidase-2 or tissue inhib
A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling
Keywords: 1,25-Dihydroxyvitamin D3; Wnt5a; Protein disulfide isomerase A3; Phospholipase A2 activating protein; Calmodulin; Protein kinase C;
Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle
Keywords: WNT5A; Steroidogenesis; Granulosa cells; Bovine;
Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments
Keywords: Epigenetics; Mesenchymal stem cells; Microarray analysis; WNT5A; GDNF; DNA methylation
miR-217 targeting Wnt5a in osteosarcoma functions as a potential tumor suppressor
Keywords: miR-217; Osteosarcoma; Wnt5a; Tumor progression
Immunohistochemical expression of WNT5A and MMPs in odontogenic epithelial tumors and cysts
Keywords: WNT5A; Odontogenic tumors; Ameloblastoma; Adenomatoid odontogenic tumor; Calcifying epithelial odontogenic tumor and calcifying cystic odontogenic tumor
Wnt5a attenuates Wnt3a-induced alkaline phosphatase expression in dental follicle cells
Keywords: Wnt5a; Wnt3a; Dental follicle cells; Alkaline phosphatase; Cell differentiation;
The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers
Keywords: Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; ACK1/TNK2; activated CDC42-associated kinase 1; AR; androgen receptor; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated related; BF; biochemical failure; DCC; deleted in colorectal cance
Wnt5a, Ryk and Ror2 expression in glioblastoma subgroups
Keywords: Wnt5a; Ryk; Ror2; β-Catenin; Glioblastoma
Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma
Keywords: DKK3; Wnt3a; Wnt5a; LRP6; Glioblastoma;
A novel function for Wnt signaling modulating neuronal firing activity and the temporal structure of spontaneous oscillation in the entorhinal–hippocampal circuit
Keywords: Entorhinal–hippocampal circuit; Slow oscillation; Wnt3a; Wnt5a
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Keywords: Wnt5a; wingless-type family member 5a; NMDA; N-methyl d-aspartic acid; NO; nitric oxide; 7-NI; 7-nitroindazole; ROR2; receptor tyrosine kinase-like orphan receptor 2; sFRP-2; soluble frizzled related protein 2; DVL; Disheveled; Wnt/PCP; Wnt/planar cell po
Lipopolysaccharide Enhances Wnt5a Expression through Toll-like Receptor 4, Myeloid Differentiating Factor 88, Phosphatidylinositol 3-OH Kinase/AKT and Nuclear Factor Kappa B Pathways in Human Dental Pulp Stem Cells
Keywords: Dental pulp stem cells; LPS; NF-kappaB; PI3K/AKT; TLR4; Wnt5a
Wnt5a: A player in the pathogenesis of atherosclerosis and other inflammatory disorders
Keywords: Wnt5a; Macrophages; Inflammation; Atherosclerosis; Inflammatory disorders; Fz; frizzled; LRP; lipoprotein receptor-related protein; Ror2; receptor tyrosine kinase-like orphan receptor; DSH; disheveled; CaMKII; calmodulin dependent protein kinase II; PKC;
The non-canonical Wnt ligand, Wnt5a, is upregulated and associated with epithelial to mesenchymal transition in epithelial ovarian cancer
Keywords: Wnt5a; Wnt signalling; Epithelial ovarian cancer; Metastasis; β-Catenin
Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A
Keywords: Cartilage; Growth plate; Perichondrium; Cell polarity; Hoxd13; Wnt5a;
Signaling components of the 1α,25(OH)2D3-dependent Pdia3 receptor complex are required for Wnt5a calcium-dependent signaling
Keywords: 1,25-Dihydroxy vitamin D3; Wnt5a; Pdia3; PKC; MC3T3-E1 osteoblast-like cells; Costochondral cartilage growth zone chondrocytes;
Wnt5a enhances the response of CML cells to Imatinib Mesylate through JNK activation and γ-catenin inhibition
Keywords: Wnt5a; Chronic myeloid leukaemia; Imatinib Mesylate; JNK; β-Catenin; γ-Catenin;
Maldevelopment of dermal lymphatics in Wnt5a-knockout-mice
Keywords: Lymphangiogenesis; Lymphatic endothelial cell; WNT5A; ROR1; RYK; FDZ3; DKK2; FABP4; AChE; LGALS3BP; ENTPD1;
Lack of association of WNT5A mutations with Müllerian duct abnormalities
Keywords: Müllerian duct abnormalities; mutation; single-nucleotide polymorphisms; WNT5A
Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells
Keywords: Rab35; Rac1; Wnt5a; Dvl2; Breast cancer; Migration;
Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis
Keywords: Wnt5a; Ror2; Osteoblast; BMP-2; Differentiation;
Wnt5a activates THP-1 monocytic cells via a β-catenin-independent pathway involving JNK and NF-κB activation
Keywords: FBS; fetal bovine serum; FHC; ferritin heave chain; HAECs; human aortic endothelial cells; IFN; interferon; IKK; IkB kinase; JNK; c-Jun N-terminus kinase; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MKK; mitogen-activated-protein kina
Induced Wnt5a expression perturbs embryonic outgrowth and intestinal elongation, but is well-tolerated in adult mice
Keywords: Wnt5a; Ror2; Intestine; Mouse model; Development; Homeostasis
Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development
Keywords: Wnt5a; Ror2; Development; Hair follicles; Calvarial mesenchyme; Mouse model
Immunolocalization of Wnt5a during the hair cycle and its role in hair shaft growth in mice
Keywords: Bu, bulge; DP, dermal papilla; IHC, immunohistochemistry; HG, secondary hair germ; HS, hair shaft; IRS, inner root sheath; ORS, outer root sheathHair follicle; Wnt5a; Non-canonical Wnt; Hair shaft growth; Immunolocalization; Mouse