YAP transcriptionally regulates ErbB2 to promote liver cell proliferation
Keywords: ایجاد; YAP; Hippo pathway; ErbB2 (HER2); Liver; Hepatocellular carcinoma (HCC);
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FAK- and YAP/TAZ dependent mechanotransduction pathways are required for enhanced immunomodulatory properties of adipose-derived mesenchymal stem cells induced by aligned fibrous scaffolds
Keywords: ایجاد; Immunomodulatory factors; Adipose-derived mesenchymal stem cells (ASCs); FAK; YAP; Mechanotransduction; Fiber orientation;
Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis
Keywords: ایجاد; Binucleated Cells; Large Tumor Suppressor Kinase; Pan-overexpressed; TEA Domain Transcription Factor; AURKB; aurora B kinase; ChIP; chromatin immunoprecipitation; CIN; chromosomal instability; CNL; noncancerous tissue; ECT2; epithelial cell transforming 2
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells
Keywords: ایجاد; Liver Diseases; Metabolic Reprogramming; Fibrogenesis; Hippo Pathway; α-KG; alpha-ketoglutarate; α-SMA; alpha-smooth muscle actin; BPTES; bis-2-[5-phenylacetamido-1,2,4-thiadiazol-2-yl] ethyl sulfide; DKG; dimethyl α-ketoglutarate; EGCG; epigallocatech
Emerging paradigms in the treatment of liver metastases in colorectal cancer
Keywords: ایجاد; CRC; colorectal cancer; mCRC; metastatic colorectal cancer; CLM; colorectal liver metastases; SR; surgical resection; PVE; portal vein embolism; RFA; radiofrequency ablation; APC; adenomatous polyposis coli; LOH; loss of heterozygosity; EGFR; epidermal gr
Deubiquitylating enzymes as cancer stem cell therapeutics
Keywords: ایجاد; Protein-IPSC; protein-induced pluripotent stem cells; CSCs; cancer stem cells; DUBs; deubiquitylating enzymes; ESCs; embryonic stem cells; PTMs; post-translational modifications; AML; acute myelogenous leukemia; USP/UBP; ubiquitin-specific processing prot
Type I collagen induces mesenchymal cell differentiation into myofibroblasts through YAP-induced TGF-β1 activation
Keywords: ایجاد; ECM remodeling; Mesenchymal cell; Myofibroblast; YAP; Oxidative stress;
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Keywords: ایجاد; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMT; amoeboid-mesenchymal transition; APC; adenomatosis polyposis coli; Arp2/3; actin related protein 2/3; Cdc42; cell division control protein 42 homolog; CK1; casein kinase 1; COX-2; cyclooxygena
Impact of obesity and overweight on DNA stability: Few facts and many hypotheses
Keywords: ایجاد; AGEs; advanced glycation end products; AP-1; activating protein -1; APE1; apurinic/apyrimidinic endonuclease 1; BER; base excision repair; BMI; body mass index; CAF; cafeteria diet; CAT; Catalase; CBMN-Cyt; cytokinesis block micronucleus cytome assay; CEL
MiR-361 targets Yes-associated protein (YAP) mRNA to suppress cell proliferation in lung cancer
Keywords: ایجاد; miR-361; YAP; Proliferation; Lung cancer; YAP; Yes-associated protein; miRNA; microRNA; STAT6; signal transducer and activator of transcription-6; real time-PCR; real-time polymerase chain reaction; EdU; 5-ethynyl-2â²-deoxyuridine;
High-temperature thermographic phosphor mixture YAP/YAG:Dy3+ and its photoluminescence properties
Keywords: ایجاد; Phosphor thermometry; Luminescence; YAP; YAG; Dysprosium;
Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway
Keywords: ایجاد; CCK8; Cell Counting Kit-8; CNS; central nervous system; DMEM; Dulbecco's modified Eagle's medium; GBM; glioblastoma; Hes-1; hairy and enhancer of split-1; Jag-1; Jagged-1; LincRNAs; long intergenic noncoding RNAs; LncRNAs; Long noncoding RNAs; MALAT1; Met
FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma
Keywords: ایجاد; NPC; FOXC2; YAP; Glycolysis; HK2;
Research PaperErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage
Keywords: ایجاد; Apoptosis; Early brain injury; ErbB4; PIK3CB; Subarachnoid hemorrhage; YAP;
Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer
Keywords: ایجاد; Chemotherapy; YAP; Protein stability; Transformative phenotypes; βTrCP;
Original contributionExpression of YES-associated protein (YAP) and its clinical significance in breast cancer tissues
Keywords: ایجاد; Yap; Breast cancer; Overall survival; Disease-free survival; Immunohistochemistry;
Original ArticleThe oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer
Keywords: ایجاد; HBXIP; YAP; c-Myb; Proliferation; Liver cancer;
Transcriptional co-activator YAP regulates cAMP signaling in Sertoli cells
Keywords: ایجاد; Sertoli cell; YAP; cAMP; Verteporfin; Phospho CREB;
Original ArticleStatin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis
Keywords: ایجاد; Statin; CD44; Hippo pathway; YAP; Cancer stem cell; Malignant mesothelioma;
Original ArticleA combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer
Keywords: ایجاد; Yes-associated protein (YAP); RAF inhibitor; Pancreatic ductal adenocarcinoma (PDAC); Combinational therapy; Verteporfin; PDAC; Pancreatic ductal adenocarcinoma; YAP; Yes-associated protein; MAP; mitogen-activated protein; IHC; immunohistochemical; DMEM;
Original ArticleSUMOylation of large tumor suppressor 1 at Lys751 attenuates its kinase activity and tumor-suppressor functions
Keywords: ایجاد; SUMOylation; Lats1; Hippo signaling; Tumor suppressor; SUMO; Small ubiquitin-like modifier; Lats; large tumor suppressor; YAP; Yes-associated protein; TAZ; transcriptional co-activator with PDZ-binding motif; Tead; TEA domain transcription factor; CTGF; c
v-Src-induced nuclear localization of YAP is involved in multipolar spindle formation in tetraploid cells
Keywords: ایجاد; v-Src; Tetraploidy checkpoint; Multipolar spindle; YAP;
Mini-reviewYAP and WWTR1: New targets for skin cancer treatment
Keywords: ایجاد; Hippo signaling; YAP; WWTR1; Skin; Cancer; Therapeutics; 14-3-3; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; ABL1; ABL proto-oncogene 1; AKT; protein kinase B; AMOT; angiomotin; BCC; basal cell carcinoma; BRAF; v-Raf murine sar
Variation of Eu3+ emissions in yttrium aluminum oxides controlled by amount of La3+ dopant
Keywords: ایجاد; Nanophosphor; YAG; YAP; Eu3+; La3+; Phase transition;
TEAD1 mediates the oncogenic activities of Hippo-YAP1 signaling in osteosarcoma
Keywords: ایجاد; Hippo; YAP; Osteosarcoma; PTGS2; CYR61;
The novel YAP target gene, SGK1, upregulates TAZ activity by blocking GSK3β-mediated TAZ destabilization
Keywords: ایجاد; SGK1; YAP; TAZ; Hippo pathway;
Synergistic induction of CTGF by cytochalasin D and TGFβ-1 in primary human renal epithelial cells: Role of transcriptional regulators MKL1, YAP/TAZ and Smad2/3
Keywords: ایجاد; CTGF; connective tissue growth factor, CCN2; CytoD; cytochalasin D; G-actin; globular actin; F-actin; filamentous actin; hPTEC; human primary tubular epithelial cells; LatB; latrunculin B; MKL1; Megakaryoblastic Leukemia 1; MYPT; myosin phosphatase target
Hippo Signaling in the Liver Regulates Organ Size, Cell Fate, and Carcinogenesis
Keywords: ایجاد; YAP1; YES-Associated Protein; WWTR1; TAZ; AJ; adherens junction; AMOT; angiomotin; CC; cholangiocardinoma; HB; hepatoblastoma; HCC; hepatocellular carcinoma; HepSC; hepatic stellate cell; LATS; large tumor suppressor kinase; PI3K; phosphoinositide 3-kinas
Biomechanical strain-induced modulation of proliferation coincides with an ERK1/2-independent nuclear YAP localization
Keywords: ایجاد; ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; FA; focal adhesion; FAK; focal adhesion kinase; hPDLF; human periodontal ligament fibroblast; IIF; indirect immunofluorescence; MAPK; mitogen activated protein kinase; MEK; MAPK/ERK ki
YAP-mediated mechanotransduction regulates osteogenic and adipogenic differentiation of BMSCs on hierarchical structure
Keywords: ایجاد; Hierarchical structure; BMSC; Differentiation; YAP; Mechanotransduction;
Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro
Keywords: ایجاد; NGS; next generation sequencing; ChIP; chromatin immunoprecipitation; ChIP-seq; chromatin immunoprecipitation followed by deep sequencing; TF; transcription factor; MSC; mesenchymal stem cell; DE; differentially expressed; TSS; transcriptional start site;
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
Keywords: ایجاد; Inflammation; Tumorigenesis; Villus Regeneration; Mouse Model; ANKRD1; ankyrin repeat domain 1; APC; adenomatous polyposis coli; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase 2; CREB; cyclic adenosine monophosphate response element binding pr
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: ایجاد; α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Light response of YAP:Ce and LaBr3:Ce scintillators to 4-30Â MeV protons for applications to Telescope Proton Recoil neutron spectrometers
Keywords: ایجاد; Neutron spectroscopy; Scintillators; Fusion; Spallation sources; YAP; LaBr3;
Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation
Keywords: ایجاد; 4ICD; HER4 intracellular domain; ATCC; American type culture collection; EGF; epidermal growth factor; EGFP; enhanced green fluorescent protein; EGFR; epidermal growth factor family; ERα; estrogen receptor alpha; FBS; fetal bovine serum; HEK; human embry
Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance
Keywords: ایجاد; YAP; EGFR; KRAS; Resistance; Lung cancer;
Mini-ReviewNetrin-1: A regulator of cancer cell motility?
Keywords: ایجاد; C. Elegans; Caernohabtidis Elegans; DCC; deleted in colorectal cancer; D. Melanogaster; Drosophila Melanogaster; DSCAM; Down syndrome cell adhesion molecule PMEC primary midgut epithelial cell; UNC-6; uncoordinated-6; UNC5; uncoordinated5; YAP; yes associ
Expression of netrin-1 by hypoxia contributes to the invasion and migration of prostate carcinoma cells by regulating YAP activity
Keywords: ایجاد; Prostate cancer; Netrin-1; Hypoxia; Cell invasion; Cell migration; YAP;
Nuclear accumulation of Yes-Associated Protein (YAP) maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression
Keywords: ایجاد; YAP; Survivin; Doxorubicin; Senescence;
Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling
Keywords: ایجاد; S1P; COX-2; PGE2; YAP; Granulosa cells;
Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure
Keywords: ایجاد; Furan; Liver cancer; Epigenetic; miRNAs; miR-375; ANT; adjacent tissue; CTGF; connective tissue growth factor; H3K9; histone 3 lysine 9; H3K27; histone 3 lysine 27; miRNAs; microRNAs; NT; normal tissue; TRT; treatment-related cholangiofibrotic tissue; YAP
Invited reviewTargeting the Hippo pathway: Clinical implications and therapeutics
Keywords: ایجاد; Hippo; Cancer; YAP;
The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP
Keywords: ایجاد; YAP; TAZ; TEAD; cAMP; 3â²-5â²-Cyclic adenosine monophosphate; VSMC;
The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination
Keywords: ایجاد; AMOT; angiomotin; AMOTL1; angiomotin-like 1; AMOTL2; angiomotin-like 2; YAP; yes-associated protein; ANG-2; angiopoietin-2; VE-cadherin; vascular endothelial cadherin; EPC; endothelial progenitor cell; OEC; outgrowing endothelial cell; HUVEC; human umbili
Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development
Keywords: ایجاد; epicardium; proepicardium; Hippo signaling; Yap; Taz; epithelial to mesenchymal transition (EMT)
The TIR/BB-loop mimetic AS-1 attenuates mechanical stress-induced cardiac fibroblast activation and paracrine secretion via modulation of large tumor suppressor kinase 1
Keywords: ایجاد; AS-1; hydrocinnamoyl-l-valylpyrrolidine; TIR; Toll/interleukin-1 receptor; IL-1R; interleukin-1 receptor; MyD88; myeloid differentiation primary response gene 88; MS; mechanical stress; LATS1; large tumor suppressor kinase 1; YAP; Yes associated protein;
Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye
Keywords: ایجاد; Yap; Retina; RPE; Transdifferentiation; Cell cycle control; Polarity; Cell proliferation;
NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia
Keywords: ایجاد; H&E; hematoxylin and eosin; IEC; intestinal epithelial cell; IF; immunofluorescence; IHC; immunohistochemistry; CRC; colorectal cancer; ERM; ezrin-radixin-moesin; NHERF1/EBP50; Na+/H+; PM; plasma membrane; SI; small intestine; YAP; Yes-associated protein
Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells
Keywords: ایجاد; CTGF; connective tissue growth factor; Cyr61; Cysteine-rich protein 61; DF; disturbed flow; EC; endothelial cells; LATS1/2; large tumor suppressor kinase 1/2; LF; laminar flow; YAP; Yes-associated protein;
MST2 phosphorylation at serine 385 in mitosis inhibits its tumor suppressing activity
Keywords: ایجاد; CDK1; cyclin-dependent kinase 1; LATS1/2; large tumor suppressor 1/2; MST1/2; mammalian sterile 20-like kinase 1/2; PLK1; polo-like kinase 1; TAZ; transcriptional co-activator with PDZ binding domain; YAP; yes-associated protein; MST2; Mitotic phosphoryla