کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5526880 | 1401554 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma FOXC2 positively regulates YAP signaling and promotes the glycolysis of nasopharyngeal carcinoma](/preview/png/5526880.png)
YAP signaling has been reported to be dysregulated in numerous cancer types. However, its roles in nasopharyngeal carcinoma (NPC) are poorly understood. Although several studies have shown that FOXC2 promotes the progression of NPC, the underlying molecular mechanism remains largely unknown. Here, we have shown that FOXC2 interacted with YAP and TEAD, and activated YAP signaling. Furthermore, FOXC2-YAP signaling positively regulated the expression of Hexokinase 2 (HK2) and promoted the glycolysis. Moreover, the inhibitor of HK2, 3-BrPA effectively inhibited the tumorigenesis of NPC cells in vitro and in vivo. Collectively, our study demonstrated that FOXC2 promoted the glycolysis in progression of NPC by activating YAP signaling, and suggested that FOXC2 might be promising therapeutic target.
Journal: Experimental Cell Research - Volume 357, Issue 1, 1 August 2017, Pages 17-24