کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10027703 | 1591910 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of oxazaborolidine activity on Streptococcus mutans biofilm formation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
Dental diseases are among the most prevalent afflictions of humankind. These diseases are associated with the formation of biofilms harbouring pathogenic bacteria. Eight different derivatives of oxazaborolidines were synthesised and evaluated for their affect on Streptococcus mutans adhesion and biofilm formation. Structure-activity relationship was observed. The B-butyl moiety of the oxazaborolidines contributed an anti-adhesion effect for all derivatives, whilst its effect diminished when the boron atom was incorporated in a fused heterocyclic ring. The B-phenyl group induced bacterial adhesion in all tested compounds Oxazaborolidines may serve as novel agents for affecting oral biofilm formation. Moreover, the ability to alter the oxazaborolidine molecule and thus affect biofilms offers an excellent opportunity to study biofilm formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 26, Issue 6, December 2005, Pages 491-496
Journal: International Journal of Antimicrobial Agents - Volume 26, Issue 6, December 2005, Pages 491-496
نویسندگان
Adel Jabbour, Morris Srebnik, Batia Zaks, Valerie Dembitsky, Doron Steinberg,