کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10032046 | 1595039 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-α in response to linoleic acid and oxidative stress
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-α in response to linoleic acid and oxidative stress Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-α in response to linoleic acid and oxidative stress](/preview/png/10032046.png)
چکیده انگلیسی
These data demonstrate that exposure of neutrophils from normal pregnant women to conditions present in preeclamptic women results in neutrophil activation with release of thromboxane and tumor necrosis factor-α. Newly synthesized thromboxane is cyclooxygenase-2 dependent and plays a role in the tumor necrosis factor-α response. Our data suggest a mechanism for maternal vasoconstriction and vascular inflammation in preeclampsia because activated, thromboxane-secreting neutrophils migrate across endothelium into the microenvironment of the vasculature in which they could promote vasoconstriction, whereas release of tumor necrosis factor-α could cause vascular inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 193, Issue 3, September 2005, Pages 830-835
Journal: American Journal of Obstetrics and Gynecology - Volume 193, Issue 3, September 2005, Pages 830-835
نویسندگان
John E. PhD, Scott W. PhD,