کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10047423 | 1598399 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Hemodynamic Effect of Calcium Ion Concentration in the Infusate During Predilution Hemofiltration in Chronic Renal Failure
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The Hemodynamic Effect of Calcium Ion Concentration in the Infusate During Predilution Hemofiltration in Chronic Renal Failure The Hemodynamic Effect of Calcium Ion Concentration in the Infusate During Predilution Hemofiltration in Chronic Renal Failure](/preview/png/10047423.png)
چکیده انگلیسی
Background: It is the prevailing view that convective dialysis techniques stabilize blood pressure. Calcium concentration in the substitution fluid may be important in this respect. The aim of this study is to investigate the influence of calcium ion concentration in the substitution fluid on hemodynamic stability during predilution hemofiltration (HF). Methods: We conducted a randomized, crossover, blinded, controlled trial with 12 stable long-term hemodialysis patients without diabetes. Each patient was randomly assigned to substitution fluid with a calcium ion (iCa) concentration of 2.5 mEq/L (1.25 mmol/L; low-calcium session [L-HF]) or 3.5 mEq/L (1.75 mmol/L; high-calcium session [H-HF]) during 4.5 hours of predilution HF with a volume of 1.24 ± 0.09 L/kg dry body weight and a temperature of 37°C. Ultrafiltration was kept constant in each patient. Blood pressure (mean, systolic [SBP], and diastolic blood pressure [DBP]), pulse rate, arterial and venous temperature, energy transfer, and relative blood volume were measured at 15-minute intervals. Cardiac output, total peripheral resistance, stroke volume, and iCa were measured hourly. The 2 treatments were matched with the exception of iCa concentration. Results: A significant intratreatment reduction in cardiac output and stroke volume was shown to the same extent for both groups. Intertreatment comparisons showed a significantly lower mean arterial pressure, SBP, DBP, and total peripheral resistance in the L-HF compared with the H-HF group. Conclusion: iCa concentration of 3.5 versus 2.5. mEq/L (1.75 versus 1.25 mmol/L) in the infusate during predilution HF stabilized blood pressure, possibly because of greater peripheral resistance rather than through changes in cardiac performance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 46, Issue 3, September 2005, Pages 470-480
Journal: American Journal of Kidney Diseases - Volume 46, Issue 3, September 2005, Pages 470-480
نویسندگان
Nikolaos MD, Erik MD, PhD, DMSc, Jens Dam MD, PhD,