کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10066 662 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanotoxicity of iron oxide nanoparticle internalization in growing neurons
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Nanotoxicity of iron oxide nanoparticle internalization in growing neurons
چکیده انگلیسی

Magnetic nanoparticles (MNPs) have shown great promise for use as tools in a wide variety of biomedical applications, some of which require the delivery of large numbers of MNPs onto or into the cells of interest. Here we develop a quantifiable model cell system and show that intracellular delivery of even moderate levels of iron oxide (Fe2O3) nanoparticles may adversely affect cell function. More specifically, we show that exposure to increasing concentrations of anionic MNPs, from 0.15 to 15 mm of iron, results in a dose-dependent diminishing viability and capacity of PC12 cells to extend neurites in response to their putative biological cue, i.e. nerve growth factor. The cytotoxicity results of biomaterials in our model system imply that more study into the acute and long-term effects of cellular Fe2O3 internalization is both warranted and necessary.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 28, Issue 16, June 2007, Pages 2572–2581
نویسندگان
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