کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10087187 1605503 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nipple-areolar pigmentation: histology and potential for reconstitution in breast reconstruction
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Nipple-areolar pigmentation: histology and potential for reconstitution in breast reconstruction
چکیده انگلیسی
The makeup of nipple-areolar skin, in terms of its melanin and melanocyte content has not previously been established. This histological information is required if pigmentation of the reconstructed nipple-areola is to be successful in post-mastectomy breast reconstruction. We describe examination of 200 parallel sections of nipple-areolar skin of 20 women using histochemical (Masson-Fontana) and immunohistochemical (Mel-5) techniques, evaluated using quantitative image analysis. The amount of melanin present per length of basement membrane was 2.14 times higher in areolar skin than breast skin. The ratio of melanocytes to keratinocytes was 1:9.7 in areolar skin vs. 1:14.7 in breast skin. We also describe a cell culture and skin construct method using autologous human serum without toxic growth promoting additives, which could be used in the clinical setting of nipple-areolar reconstruction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: British Journal of Plastic Surgery - Volume 58, Issue 2, March 2005, Pages 202-208
نویسندگان
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