Cholesterol Feeding Reduces Vascular Endothelial Growth Factor Signaling in Rabbit Corporal Tissues

Hypercholesterolemia results in decreased VEGF signaling and decreased levels of the active form of eNOS in corporal tissue. Levels of nNOS were reduced by a different mechanism. VEGF signaling may provide a target to modulate ED. Xie D, Kontos CD, Donatucci CF, and Annex BH. Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues. J Sex Med 2005;2:634-640.