ORIGINAL RESEARCH-EJACULATORY DISORDERS: On‐Demand SSRI Treatment of Premature Ejaculation: Pharmacodynamic Limitations for Relevant Ejaculation Delay and Consequent Solutions

On‐demand SSRI treatment has less ejaculation‐delaying effects than daily SSRI treatment. SSRIs with a short half‐life are likely leading to much less ejaculation delay than current registered SSRIs. Combined use of SSRIs with 5‐HT1A receptor antagonists increases the likelihood of clinically relevant ejaculation delay after on‐demand treatment. On‐demand SSRIs with short half‐life that insufficiently delay ejaculation in men with IELTs less than 1 minute should be called ejaculation‐delaying drugs rather than drugs against premature ejaculation.