کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10103377 1612062 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Angiogenesis and the tumour hypoxia response in prostate cancer: A review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Angiogenesis and the tumour hypoxia response in prostate cancer: A review
چکیده انگلیسی
The formation of new blood vessels, angiogenesis, is a highly-regulated active process that is critical for the development of the normal and malignant prostate. The vascular endothelial growth factor (VEGF) system assumes a critical role in the angiogenic process. Angiogenesis is a prerequisite for the expansion of solid tumours beyond 1-3 mm3 and is stimulated in response to a hypoxic environment. This review discusses the process of angiogenesis and the key angiogenic mediator, VEGF, and their role in tumour progression and metastasis. A better understanding of the mechanisms behind angiogenesis will ultimately lead to the development of new anti-angiogenic agents in the management of prostate cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 3, Issue 1, 2005, Pages 61-67
نویسندگان
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