Polymerized Hemoglobin Induces Heme Oxygenase-1 Protein Expression and Inhibits Intercellular Adhesion Molecule-1 Protein Expression in Human Lung Microvascular Endothelial Cells

Polymerized hemoglobin attenuates lipopolysaccharide-stimulated expression of intercellular adhesion molecule-1 protein, which is associated with upregulation of the cytoprotective protein HO-1 in human pulmonary endothelial cells. This antiinflammatory effect offers a novel mechanism by which hemoglobin-based oxygen carrier solutions may be exploited therapeutically as resuscitative fluids.