Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer

The ECM protein Cyr61 shows increased expression in metastatic lesions in a clinically relevant model of pancreatic adenocarcinoma. Protein analysis confirms the microarray results and collocalization of Cyr61, and αv suggests that interaction between Cyr61 and αvβ3 promotes formation of peritoneal metastases.