Crosstalk between unfolded protein response and Nrf2-mediated antioxidant defense in Di-(2-ethylhexyl) phthalate-induced renal injury in quail (Coturnix japonica)

DEHP exposure induced renal injury and destroyed the pathophysiological integrity of the kidney in quail. DEHP-induced nephrotoxicity is associated with oxidative stress, which could be regulated by Nrf2-mediated defense response. DEHP exposure activated the UPR signaling pathway to prevent ER stress in the kidney.207