Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation

Low-dose almitrine (4 μg kg−1 min−1) together with inhaled NO significantly improves oxygenation during open-chest OLV, without modifying pulmonary haemodynamics. An increased dose of almitrine (16 μg kg−1 min−1) with inhaled NO further improves arterial oxygenation, but also increases mean pulmonary artery pressure.