Release of tumour necrosis factor α (TNFα) by TNFα cleaving enzyme (TACE) in response to septic stimuli in vitroâ€

The regulation of memTNF by TACE on monocytes is an important regulatory event in the pro-inflammatory cytokine cascade. As monocytes are important in the inflammatory cascade, we suggest that the control of memTNF and TACE activity on monocytes may play a role in the pathophysiology of sepsis.