کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10129175 | 1645202 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of gamma irradiation on structure, physicochemical and immunomodulatory properties of Astragalus polysaccharides
ترجمه فارسی عنوان
اثر تابش گاما بر خواص ساختاری، خواص فیزیکوشیمیایی و ایمن سازی پلی ساکارید های استراولوز
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کلمات کلیدی
پلی ساکارید استراز، اشعه گاما، خواص فیزیکی و شیمیایی و ایمن سازی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
Astragalus polysaccharides (APS) were treated with different gamma irradiation doses (10, 25, 50, 100 and 150â¯kGy) to investigate the effects of gamma radiation processing on structure, physicochemical and immunomodulatory properties. The results revealed both the number-average and weight-average molecular weight of APS significantly decreased with increasing irradiation dose, whereas the solubility was increased after irradiation. A decrease in the apparent viscosity, as well as an increase in amount of small fragments of APS granules was also observed with increasing irradiation dose. FT-IR spectra indicated that gamma irradiation introduced no significant changes into the functional group status of APS. High irradiation dose (>50â¯kGy) caused a significant increase of yellowness and a slightly decrease of thermal stability of APS. Further, the immunomodulatory activity of irradiated APS was evaluated on Caco2 cells. APS irradiated at dose of 25â¯kGy exhibited the highest ability to induce nitric oxide production and up-regulate the mRNA expression of inflammatory cytokines, occludin, zonula occludens protein-1 (ZO-1) and toll-like receptor 4 (TLR4), as well as the protein expression of ZO-1 and TLR4. These findings indicate that gamma irradiation modification with a proper dose enhance immunomodulatory activity of APS by improving physicochemical properties without changing the functional groups.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 120, Part A, December 2018, Pages 641-649
Journal: International Journal of Biological Macromolecules - Volume 120, Part A, December 2018, Pages 641-649
نویسندگان
Lina Ren, Xiaofei Wang, Shan Li, Jiaolong Li, Xudong Zhu, Lin Zhang, Feng Gao, Guanghong Zhou,