Association of MTHFR and TNF-α genes polymorphisms with susceptibility to Legg-Calve-Perthes disease in Iranian children: A case-control study

Our case-control study failed to determine any association of MTHFR (677C > T and 1298A > C) and TNF-α (−308G > A and −238G > A) polymorphisms with LCPD risk. More studies with larger sample size are warranted to validate our findings.