کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10156925 1666435 2018 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus
چکیده انگلیسی
GPCRs are among the most abundant surface receptors that play diverse roles including cell signalling and molecular transportation. They are major therapeutic receptor targets against various diseases like cancer and diabetes. A number of new GPCRs are being consistently being identified and deorphanised. Among them, some GPCRs are constitutively expressed while others are down-regulated. New therapeutic agents in the form of small molecule, synthetic peptides, and recombinant nucleic acids and proteins act as antagonists and agonists against various GPCR targets that potentially regulate glucose homeostasis. In the current review, we intend to summarize the various categories of GPCRs. At the same time, we intend to highlight the major GPCRs that have been targeted by various pharmaceutical companies against diabetes mellitus. In addition, we intended to summarize the most recently identified orphan GPCRs and their therapeutic potential against diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Biological Macromolecules - Volume 118, Part B, 15 October 2018, Pages 2237-2244
نویسندگان
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