کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10157397 1666462 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Humanized mouse model for evaluating biocompatibility and human immune cell interactions to biomaterials
ترجمه فارسی عنوان
مدل موش انسانی برای ارزیابی سازگاری بیولوژیک و تعاملات سلول های ایمنی بدن با مواد بیولوژیکی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی
Immune system humanized mice provide unique platforms for improving preclinical evaluation of the human immune response to novel biomaterial therapies. Wild-type animals and human immune cell in vitro cultures provide limited representation of the human immune response, leading to unexpected responses to therapies in human patients. Introducing human tissue, cells, and genes into immunodeficient mice have advanced these animal models to reconstitute multiple lineages of functional and maturely differentiated human immune cell populations. Safe implantation and remodeling responses promoting stable tissue resolutions are critical parameters coordinated by the immune response, which should be evaluated for new biomaterial therapeutics. This review discusses the development of immune system humanized mice, and highlights demonstrated use in biomaterial and related human immune response studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Disease Models - Volume 24, Summer 2017, Pages 23-29
نویسندگان
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