Przewlekłe nawracajÄ ce wieloogniskowe zapalenie kości i szpiku - trudności diagnostyczne

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare disease of presumptive autoimmune etiology, characterized by aseptic inflammation of osseous tissue. CRMO is the most severe form of sterile inflammation of bone in children. Diagnostic problems in two girls suffering from severe form of CRMO are presented. To differentiate CRMO from neoplastic process was the main diagnostic challenge. Treatment with antibiotics and non-steroidal antiinfl ammatory drugs were not effective. Intravenous infusions with sodium pamidronate were introduced resulting in clinical improvement.