Hepatotoksyczność leków stosowanych u noworodków

Liver's development process includes growth and maturing. These changes in the structure and function have a major impact on the way drugs and other xenobiotics undergo the processes of biotransformation. Medications and their metabolic products may be toxic to the liver as well as other organs of the body. This article is a review of knowledge about the development of liver, dynamic changes in its structure and function and hepatic toxicity of xenobiotics. Particular attention was paid to reviewing substances toxic for the newborn. It was considered necessary to take into account aspects of the anatomical, physiological and developmental susceptibility of liver to xenobiotics.