Irsogladine maleate regulates barrier function and neutrophil accumulation in the gingival epithelium

► Irsogladine maleate has been used clinically as an anti-gastric ulcer agent. ► Irsogladine maleate regulates the neutrophil accumulation in gingival epithelium. ► Irsogladine maleate also controls barrier function in gingival epithelium. ► Irsogladine maleate may be useful for the prevention of periodontal inflammation.