کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10175269 1266837 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ارتوپدی، پزشکی ورزشی و توانبخشی
پیش نمایش صفحه اول مقاله
The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates
چکیده انگلیسی
We detected Venus signals in forelimb tendons, pulleys, and volar plates (VPs) in P21 mice. In-depth histological analysis showed that compared to the wild-type mice, the Mkx knockout mice showed significant hypoplasia in the flexor digitorum profundus tendons from E18.5. The VPs and pulleys appeared normal until P0; however, by P14, they became increasingly thicker in Mkx-null mice compared to wild-type mice. The fiber alignment was particularly disrupted in VPs of Mkx-null mice. Conclusions These results suggest that Mkx is an important regulator of the differentiation of VPs and pulleys, as well as of tendon differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Orthopaedic Science - Volume 19, Issue 1, January 2014, Pages 172-180
نویسندگان
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