کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10214016 1676266 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A proposed mechanism for the Berecek phenomenon with implications for cardiovascular reprogramming
ترجمه فارسی عنوان
مکانیسم پیشنهادی برای پدیده برکک با پیامدهای برنامه ریزی قلب و عروق
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
چکیده انگلیسی
Berecek et al reported in the 1990s that when spontaneously hypertensive rat (SHR) mating pairs were treated with captopril and the resulting pups were continued on the drug for 2 months followed by drug discontinuation, the pups did not develop full blown hypertension, and the cardiovascular structural changes associated with hypertension in SHR were mitigated. The offspring of the pups also displayed diminished hypertension and structural changes, suggesting that the drug therapy produced a heritable amelioration of the SHR phenotype. This observation is reviewed. The link between cellular renin angiotensin systems and epigenetic histone modification is explored, and a mechanism responsible for the observation is proposed. In any case, the observations of Berecek are sufficiently intriguing and biologically important to merit re-exploration and definitive explanation. Equally important is determining the role of renin angiotensin systems in epigenetic modification.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 12, Issue 9, September 2018, Pages 644-651
نویسندگان
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