White matter abnormalities predict residual negative self-referential thinking following treatment of late-life depression with escitalopram: A preliminary study

Negative self-referential thinking improved in depressed older adults following 12 weeks of treatment with escitalopram. Baseline FA in select white matter regions of the NVS was associated with residual negative self-referential thinking. These findings may help identify treatment targets for residual negative self-referential thoughts.