کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10223139 | 1701010 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
2-(4-Methoxyphenyl)ethyl-2-Acetamido-2-deoxy-β-d-pyranoside (A Salidroside Analog) Confers Neuroprotection with a Wide Therapeutic Window by Regulating Local Glucose Metabolism in a Rat Model of Cerebral Ischemic Injury
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
MCATTCi.v.GluTs2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chlorideROIs - ROI هاPositron emission tomography (PET) - توموگرافی انتشار پوزیترون (PET)Positron emission tomography - توموگرافی گسیل پوزیترونglucose transporters - حمل و نقل گلوکزGlucose transporter - حمل و نقل گلوکزintravenously - داخل وریدیIschemic stroke - سکته مغزی ایسکمیکmiddle cerebral artery - شریان مغزی میانیGlucose metabolism - متابولیسم گلوکزregions of interests - مناطق منافعPET - پتTherapeutic time window - پنجره زمان درمانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside (salidroside analog-4g, SalA-4g), has shown neuroprotective prospects for the treatment of ischemic stroke. However, the dose-response and time window study for SalA-4g, and the mechanism of SalA-4g-mediated neuroprotection remain unclear. Here, we systematically investigated the therapeutic time window and dosage of SalA-4g in permanent focal cerebral ischemia in rats. SalA-4g dose-dependently improved stroke outcome. Either pre-treatment or post-treatment of SalA-4g exhibited notable neuroprotection, and maintained for up to 6â¯h after ischemia onset. Moreover, significant neurological functional recovery was found after SalA-4g administration in long-term functional assays. Further studies suggested that SalA-4g ameliorated neuronal cell death, elevated local glucose metabolism and enhanced the expression level of glucose transporter 1 and 3 in the ipsilateral cortex and striatum. We suggest that data of this study are critical in exploring the clinical application prospects of SalA-4g for the treatment of ischemic stroke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 391, 1 November 2018, Pages 60-72
Journal: Neuroscience - Volume 391, 1 November 2018, Pages 60-72
نویسندگان
Shu Yu, Hui Xu, Xiaojing Chi, Li Wei, Qiong Cheng, Yumin Yang, Chun Zhou, Fei Ding,