کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10227612 | 451 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Myotube formation on gelatin nanofibers - Multi-walled carbon nanotubes hybrid scaffolds
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Engineering functional muscle tissue requires the formation of densely packed, aligned, and mature myotubes. To enhance the formation of aligned myotubes with improved contractibility, we fabricated aligned electrospun gelatin multi-walled carbon nanotubes (MWNTs) hybrid fibers that were used as scaffolds for the growth of myoblasts (C2C12). The MWNTs significantly enhanced myotube formation by improving the mechanical properties of the resulting fibers and upregulated the activation of mechanotransduction related genes. In addition, the fibers enhanced the maturation of the myotubes and the amplitude of the myotube contractions under electrical stimulation (ES). Such hybrid material scaffolds may be useful to direct skeletal muscle cellular organization, improve cellular functionality and tissue formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 35, Issue 24, August 2014, Pages 6268-6277
Journal: Biomaterials - Volume 35, Issue 24, August 2014, Pages 6268-6277
نویسندگان
Serge Ostrovidov, Xuetao Shi, Ling Zhang, Xiaobin Liang, Sang Bok Kim, Toshinori Fujie, Murugan Ramalingam, Mingwei Chen, Ken Nakajima, Faten Al-Hazmi, Hojae Bae, Adnan Memic, Ali Khademhosseini,